Electro-osmotic flow control for living cell analysis in microfluidic PDMS chips

Mechanics Research Communications

Volumn 36, Issue 1, 2009, Pages 75-81

  Glawdel, Tomasz ^a   Ren, Carolyn L ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Electro osmotic pump; Gel salt bridge; Living cell analysis; Microfluidic platform

Indexed keywords

CELL MEMBRANES; CHANNEL FLOW; CYTOLOGY; ELECTRIC FIELDS; ELECTROOSMOSIS; GELATION; GELS; MICROCHANNELS; MICROFLUIDICS; OSMOSIS; PUMPS; SILICONES;

CELL CULTURE LINES; CULTURE CHAMBERS; DIFFERENTIAL MODES; DYNAMIC STUDIES; ELECTRO-OSMOTIC FLOWS; ELECTRO-OSMOTIC PUMP; ELECTRODE RESERVOIRS; ELECTROPORATION; FLEXIBLE FLOWS; GEL SALT BRIDGE; HIGH ELECTRIC FIELDS; LIVING CELL ANALYSIS; MICROFLUIDIC PLATFORM; PARALLEL CHANNELS; PARALLEL MICROCHANNELS; PDMS CHIPS; PRESSURE DISTURBANCES;

CELL CULTURE;

EID: 60049098753     PISSN: 00936413     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mechrescom.2008.06.015     Document Type: Article

References (29)

1. Braschler T., Metref L., Zvitov-Marabi R., van Lintel H., Demierre N., Theytaz J., and Renaud P. A simple pneumatic setup for driving microfluidics. Lab Chip 7 (2007) 420-422
2. Brask A., Kutter J.P., and Bruus H. Long-term stable electroosmotic pump with ion exchange membranes. Lab Chip 5 (2005) 730-738
3. Chen C.H., and Santiago J.G. A planar electroosmotic micropump. J. Microelectromech. Syst. 11 (2002) 672-683
4. Chen L.X., Ma J.P., and Guan Y.F. Study of an electroosmotic pump for liquid delivery and its application in capillary column liquid chromatography. Sensor Actuator, A 1028 (2004) 219-226
5. de Jesus D.P., Brito-Neto J.G.A., Richter E.M., Angnes L., Gutz I.G.R., and do Lago C.L. Extending the lifetime of the running electrolyte in capillary electrophoresis by using additional compartments for external electrolysis. Anal. Chem. 77 (2005) 607-614
6. El-Ali J., Sorger P.K., and Jensen K.F. Cells on chips. Nature 442 (2006) 403-411
7. Futai N., Gu W., Song J.W., and Takayama S. Handheld recirculation system and customized media for microfluidic cell culture. Lab Chip 6 (2006) 149-154
8. Glawdel, T., 2007. Design, Fabrication and Characterization of Electrokinetically Pumped Microfluidic Chips for Cell Culture Applications. Mechanical and Mechatronics Engineering. Waterloo, University of Waterloo. M.A.Sc: 222.
9. Gomez-Sjoberg R., Leyrat A.A., Pirone D.M., Chen C.S., and Quake S.R. Versatile, fully automated, microfluidic cell culture system. Anal. Chem. 79 (2007) 8557-8563
10. Jonsson M., and Lindberg U. A planar polymer microfluidic electrocapture device for bead immobilization. J. Micromech. Microeng. 16 (2006) 2116-2120
11. Kim L., Vahey M.D., Lee H.Y., and Voldman J. Microfluidic arrays for logarithmically perfused embryonic stem cell culture. Lab Chip 6 (2006) 394-406
12. Kirby B.J., and Hasselbrink E.F. Zeta potential of microfluidic substrates: 1. Theory, experimental techniques, and effects on separations. Electrophoresis 25 (2004) 187-202
13. Leclerc E., Sakai Y., and Fujii T. Microfluidic PDMS (polydimethylsiloxane) bioreactor for large-scale culture of hepatocytes. Biotechnol. Prog. 20 (2004) 750-755
14. Lee D.W., and Cho Y.H. A continuous electrical cell lysis device using a low dc voltage for a cell transport and rupture. Sensor Actuator, B 124 (2007) 84-89
15. Liu S.R., Pu Q.S., and Lu J.J. Electric field-decoupled electroosmotic pump for microfluidic devices. J. Chromatogr. A 1013 (2003) 57-64
16. Lu H., Koo L.Y., Wang W.C.M., Lauffenburger D.A., Griffith L.G., and Jensen K.F. Microfluidic shear devices for quantitative analysis of cell adhesion. Anal. Chem. 76 (2004) 5257-5264
17. Park J.Y., Hwang C.M., Lee S.H., and Lee S.H. Gradient generation by an osmotic pump and the behavior of human mesenchymal stem cells under the fetal bovine serum concentration gradient. Lab Chip 7 (2007) 1673-1680
18. Qiao R., and Aluru N.R. A compact model for electroosmotic flows in microfluidic devices. J. Micromech. Microeng. 12 (2002) 625-635
19. Rodriguez I., and Chandrasekhar N. Experimental study and numerical estimation of current changes in electroosmotically pumped microfluidic devices. Electrophoresis 26 (2005) 1114-1121
20. Sze A., Erickson D., Ren L.Q., and Li D.Q. Zeta-potential measurement using the Smoluchowski equation and the slope of the current-time relationship in electroosmotic flow. J. Colloid Interf. Sci. 261 (2003) 402-410
21. Takamura Y., Onoda H., Inokuchi H., Adachi S., Oki A., and Horiike Y. Low-voltage electroosmosis pump for stand-alone microfluidics devices. Electrophoresis 24 (2003) 185-192
22. Tripp J.A., Svec F., Frechet J.M.J., Zeng S.L., Mikkelsen J.C., and Santiago J.G. High-pressure electroosmotic pumps based on porous polymer monoliths. Sensor Actuator, B 99 (2004) 66-73
23. Xuan X.C., and Li D.Q. Analysis of electrokinetic flow in microfluidic networks. J. Micromech. Microeng. 14 (2004) 290-298
24. Xuan X.C., Xu B., Sinton D., and Li D.Q. Electroosmotic flow with Joule heating effects. Lab Chip 4 (2004) 230-236
25. Yan D.G., Nguyen N.T., Yang C., and Huang X.Y. Visualizing the transient electroosmotic flow and measuring the zeta potential of microchannels with a micro-PIV technique. J. Chem. Phys. 124 (2006)
26. Yao S.H., Hertzog D.E., Zeng S.L., Mikkelsen J.C., and Santiago J.G. Porous glass electroosmotic pumps: design and experiments. J. Colliod Interf. Sci. 268 (2003) 143-153
27. Yao S.H., Myers A.M., Posner J.D., Rose K.A., and Santiago J.G. Electroosmotic pumps fabricated from porous silicon membranes. J. Microelectromech. Syst. 15 (2006) 717-728
28. Yao S.H., and Santiago J.G. Porous glass electroosmotic pumps: theory. J. Colliod Interf. Sci. 268 (2003) 133-142
29. Zhu X.Y., Chu L.Y., Chueh B.H., Shen M.W., Hazarika B., Phadke N., and Takayama S. Arrays of horizontally-oriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation. Analyst 129 (2004) 1026-1031