HDAC and Hsp90 inhibitors down-regulate PTTG1/securin but do not induce aneuploidy

Genes Chromosomes and Cancer

Volumn 48, Issue 2, 2009, Pages 194-201

  Hernández, Agustín ^a,c   López Lluch, Guillermo ^b   Navas, Plácido ^b   Pintor Toro, José A ^a  

^a CABIMER Andalusian Center for Molecular Biology and Regenerative Medicine CSIC University of Seville UPO   (Spain)

^b CSIC   (Spain)

^c Universidad de Sevilla CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID; DICOUMAROL; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; NICOTINAMIDE; NOVOBIOCIN; PACLITAXEL; RNA; SECURIN; TANESPIMYCIN; VALPROIC ACID;

ANEUPLOIDY; ARTICLE; CARCINOMA CELL; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE REGULATION; CELL STRAIN HCT116; CHROMATID EXCHANGE; COLON CARCINOMA; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE EXPRESSION; GENE REPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RNA INTERFERENCE;

EID: 59949097636     PISSN: 10452257     EISSN: 10982264     Source Type: Journal    
DOI: 10.1002/gcc.20630     Document Type: Article

References (30)

1. Bernal JA, Hernandez A. 2007. p53 stabilization can be uncoupled from its role in transcriptional activation by loss of PTTG1/securin. J Biochem (Tokyo) 141:737-745.
2. Bernal JA, Luna R, Espina A, Lazaro I, Ramos-Morales F, Romero F, Arias C, Silva A, Tortolero M, Pintor-Toro JA. 2002. Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis. Nat Genet 32:306-311.
3. Bernal JA, Roche M, Mendez-Vidal C, Espina A, Tortolero M, Pintor-Toro JA. 2008. Proliferative potential after DNA damage and non-homologous end joining are affected by loss of securin. Cell Death Differ 15:202-212.
4. David G, Turner GM, Yao Y, Protopopov A, DePinho RA. 2003. mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. Genes Dev 17:2396-2405.
5. Funabiki H, Kumada K, Yanagida M. 1996. Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes. EMBO J. 15:6617-6628.
6. Gomez-Vargas P, Vig BK. 2002. Differential induction of numerical chromosome changes by sodium butyrate in two transformed cell lines. Cancer Genet Cytogenet 138:56-63.
7. Gorr IH, Boos D, Stemmann O. 2005. Mutual inhibition of separase and Cdk1 by two-step complex formation. Mol Cell 19: 135-141.
8. Heaney AP, Singson R, McCabe CJ, Nelson V, Nakashima M, Melmed S. 2000. Expression of pituitary-tumour transforming gene in colorectal tumours. Lancet 355:716-719.
9. Hernandez A, Lopez-Lluch G, Bernal JA, Navas P, Pintor-Toro JA. 2008. Dicoumarol down-regulates human PTTG1/securin mRNA expression through inhibition of Hsp90. Mol Cancer Ther 7:474-482.
10. Huang X, Hatcher R, York JP, Zhang P. 2005. Securin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells. Mol Biol Cell 16:4725-4732.
11. Ikui AE, Yang CP, Matsumoto T, Horwitz SB. 2005. Low concentrations of taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy. Cell Cycle 4:1385-1388.
12. Jallepalli PV, Waizenegger IC, Bunz F, Langer S, Speicher MR, Peters JM, Kinzler KW, Vogelstein B, Lengauer C. 2001. Securin is required for chromosomal stability in human cells. Cell 105:445-457.
13. Joseph J, Wajapeyee N, Somasundaram K. 2005. Role of p53 status in chemosensitivity determination of cancer cells against histone deacetylase inhibitor sodium butyrate. Int J Cancer 115:11-18.
14. Kim DS, Franklyn JA, Smith VE, Stratford AL, Pemberton HN, Warfield A, Watkinson JC, Ishmail T, Wakelam MJ, McCabe CJ. 2007. Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity. Carcinogenesis 28:749-759.
15. Kimata Y, Matsuyama A, Nagao K, Furuya K, Obuse C, Yoshida M, Yanagida M. 2008. Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin. J Cell Sci 121:1107-1118.
16. Larsen JK, Christensen IJ, Kieler J. 1995. Cell cycle perturbation by sodium butyrate in tumorigenic and non-tumorigenic human urothelial cell lines assessed by flow cytometric bromodeoxyuridine/DNA analysis. Cell Prolif 28:359-371.
17. Mei J, Huang X, Zhang P. 2001. Securin is not required for cellular viability, but is required for normal growth of mouse embryonic fibroblasts. Curr Biol 11:1197-1201.
18. Muehlbauer PA, Schuler MJ. 2005. Detection of numerical chromosomal aberrations by flow cytometry: A novel process for identifying aneugenic agents. Mutat Res 585:156-169.
19. Niikura Y, Ohta S, Vandenbeldt KJ, Abdulle R, McEwen BF, Kitagawa K. 2006. 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: A novel mechanism by which 17-AAG inhibits cell proliferation. Oncogene 25:4133-4146.
20. Nimmanapalli R, Fuino L, Bali P, Gasparetto M, Glozak M, Tao J, Moscinski L, Smith C, Wu J, Jove R, Atadja P, Bhalla K. 2003. Histone deacetylase inhibitor LAQ824 both lowers expression and promotes proteasomal degradation of Bcr-Abl and induces apoptosis of imatinib mesylate-sensitive or -refractory chronic myelogenous leukemia-blast crisis cells. Cancer Res 63:5126-5135.
21. Pfleghaar K, Heubes S, Cox J, Stemmann O, Speicher MR. 2005. Securin is not required for chromosomal stability in human cells. PLoS Biol 3:e416.
22. Pines J. 2006. Mitosis: A matter of getting rid of the right protein at the right time. Trends Cell Biol 16:55-63.
23. Ramaswamy S, Ross KN, Lander ES, Golub TR. 2003. A molecular signature of metastasis in primary solid tumors. Nat Genet 33:49-54.
24. Romero F, Multon MC, Ramos-Morales F, Dominguez A, Bernal JA, Pintor-Toro JA, Tortolero M. 2001. Human securin, hPTTG, is associated with Ku heterodimer, the regulatory subunit of the DNA-dependent protein kinase. Nucleic Acids Res 29:1300-1307.
25. Rosenhagen MC, Soti C, Schmidt U, Wochnik GM, Hartl FU, Holsboer F, Young JC, Rein T. 2003. The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation. Mol Endocrinol 17:1991-2001.
26. Sowa Y, Sakai T. 2000. Butyrate as a model for ''gene-regulating chemoprevention and chemotherapy.'' Biofactors 12:283-287.
27. Venkitaraman AR. 2007. Chromosomal instability in cancer: Causality and interdependence. Cell Cycle 6:2341-2343.
28. Vlotides G, Eigler T, Melmed S. 2007. Pituitary tumor-transforming gene: Physiology and implications for tumorigenesis. Endocrine Rev 28:165-186.
29. Wang Y, Wang SY, Zhang XH, Zhao M, Hou CM, Xu YJ, Du ZY, Yu XD. 2007. FK228 inhibits Hsp90 chaperone function in K562 cells via hyperacetylation of Hsp70. Biochem Biophys Res Commun 356:998-1003.
30. Yamamoto A, Guacci V, Koshland D. 1996. Pds1p is required for faithful execution of anaphase in the yeast, Saccharomyces cerevisiae. J Cell Biol 133:85-97.