Unexpected autocrine role of vascular endothelial growth factor in squamous cell carcinoma

Journal of Investigative Dermatology

Volumn 129, Issue 3, 2009, Pages 538-540

  Arbiser, Jack L ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HONOKIOL; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NOTCH RECEPTOR; PHOSPHATIDIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE D; PROTEIN KINASE B; PROTEIN P53; PROTEIN TYROSINE KINASE; RAC PROTEIN; REACTIVE OXYGEN METABOLITE; SONIC HEDGEHOG PROTEIN; SORAFENIB; STAT1 PROTEIN; STAT3 PROTEIN; VASCULOTROPIN; VASCULOTROPIN 121; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ANOIKIS; AUTOCRINE EFFECT; BREAST CARCINOMA; CARCINOGENESIS; COLON CARCINOMA; DRUG DELIVERY SYSTEM; ENZYME ACTIVATION; HUMAN; KERATINOCYTE; KIDNEY CARCINOMA; LUNG CARCINOGENESIS; LUNG CARCINOMA; NONHUMAN; NOTE; ONCOGENE RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOLID TUMOR; SQUAMOUS CELL CARCINOMA; TUMOR VASCULARIZATION;

EID: 59949092667     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.427     Document Type: Note

References (16)

1. Arbiser, JL (2004) Molecular regulation of angiogenesis and tumorigenesis by signal transduction pathways: evidence of predictable and reproducible patterns of synergy in diverse neoplasms. Semin Cancer Biol 14:81-91
2. Arbiser JL (2007) Why targeted therapy hasn't worked in advanced cancer. J Clin Invest 117:2762-5
3. Arbiser JL, Larsson H, Claesson-Welsh L, Bai X, LaMontagne K, Weiss SW et al. (2000) Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo. Am J Pathol 156:1469-76
4. Brown LF, Dezube BJ, Tognazzi K, Dvorak HF, Yancopoulos GD (2000) Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcoma. Am J Pathol 156:2179-83
5. Garcia A, Zheng Y, Zhao C, Toschi A, Fan J, Shraibman N et al. (2008) Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells. Clin Cancer Res 14:4267-74
6. Holmgren L, O'Reilly MS, Folkman J (1995) Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis supression. Nat Med 1: 149-53
7. Holmqvist K, Cross MJ, Rolny C, Hagerkvist R, Rahimi N, Matsumoto T et al. (2004) The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J Biol Chem 279:22267-75
8. Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W et al. (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-42
9. LaMontagne KR Jr, Moses MA, Wiederschain D, Mahajan S, Holden J, Ghazizadeh H et al. (2000) Inhibition of MAP kinase kinase causes morphological reversion and dissociation between soft agar growth and in vivo tumorigenesis in angiosarcoma cells. Am J Pathol 157:1937-45
10. Matsumoto T, Mugishima H (2006) Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis. J Atheroscler Thromb 13:130-5
11. Mirones I, Conti CJ, Martínez J, Garcia M, Larcher F (2009) Complexity of VEGF responses in skin carcinogenesis revealed through ex vivo assays based on a VEGF-A null mouse keratinocyte cell line. J Invest Dermatol 129:730-41
12. Ramaswamy B, Elias AD, Kelbick NT, Dodley A, Morrow M, Hauger M et al. (2006) Phase II trial of bevacizumab in combination with weekly docetaxel in metastatic breast cancer patients. Clin Cancer Res 12:3124-9
13. Weterman MA, Wilbrink M, Geurts van Kassel A (1996) Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)- positive papillary renal cell carcinomas. Proc Natl Acad Sci USA 93:15294-8
14. Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong RT et al. (2004) Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 10:145-7
15. Zheng Y, Rodrik V, Toschi A, Shi M, Hui L, Shen Y et al. (2006) Phospholipase D couples survival and migration signals in stress response of human cancer cells. J Biol Chem 281:15862-8
16. Zhong M, Shen Y, Zheng Y, Joseph T, Jackson D, Foster DA (2003) Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells. Biochem Biophys Res Commun 302:615-9