Phospholipase D prevents apoptosis in v-Src-transformed rat fibroblasts and MDA-MB-231 breast cancer cells

Biochemical and Biophysical Research Communications

Volumn 302, Issue 3, 2003, Pages 615-619

  Zhong, Minghao ^a,b   Shen, Yingjie ^a,c   Zheng, Yang ^a   Joseph, Troy ^a,d   Jackson, Desmond ^a   Foster, David A ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLIPASE D; PHOSPHOLIPASE D1; PROTEIN TYROSINE KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL TRANSFORMATION; ENZYME ACTIVITY; ENZYME INACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0037436828     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00229-8     Document Type: Article

References (16)

1. Biscardi J.S., Belsches A.P., Parsons S.J. Characterization of human epidermal growth factor receptor and c-Src interactions in human breast tumor cells. Mol. Carcinog. 21:1998;261-272.
2. Lu Z., Hornia A., Jiang Y., Frankel P., Zang Q., Foster D.A. Tumor-promotion by depleting cells of protein kinase C δ Mol. Cell. Biol. 17:1997;3418-3428.
3. Lu Z., Hornia A., Joseph T., Sukezane T., Frankel P., Zhong M., Bychenok S., Xu L., Feig L.A., Foster D.A. Phospholipase D and RalA cooperate with the EGF receptor to transform 3Y1 rat fibroblasts. Mol. Cell. Biol. 20:2000;462-467.
4. Joseph T.R., Wooden R., Bryant A., Zhong M., Lu Z., Foster D.A. Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2. Biochem. Biophys. Res. Commun. 289:2001;1019-1024.
5. Zhong M., Lu Z., Foster D.A. Downregulating PKC δ provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene. 21:2002;1071-1078.
6. Noh D.Y., Ahn S.J., Lee R.A., Park I.A., Kim J.H., Suh P.G., Ryu S.H., Lee K.H., Han J.S. Overexpression of phospholipase D1 in human breast cancer tissues. Cancer Lett. 161:2000;207-214.
7. Zhao Y., Ehara H., Akao Y., Shamoto M., Nakagawa Y., Banno Y., Deguchi T., Ohishi N., Yagi K., Nozawa Y. Increased activity and intranuclear expression of phospholipase D2 in human renal cancer. Biochem. Biophys. Res. Commun. 278:2000;140-143.
8. Zhong M., Lu Z., Abbas T., Hornia A., Chatakondu K., Barile N., Kaplan P., Foster D.A. Novel tumor-promoting property of tamoxifen. Cell Growth Differ. 12:2001;187-192.
9. Joseph T., Bryant A., Wooden R., Kerkhoff E., Rapp U.R., Foster D.A. Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling. Oncogene. 21:2002;3651-3658.
10. Shen Y., Xu L., Foster D.A. Phospholipase D requirement for receptor-mediated endocytosis. Mol. Cell. Biol. 21:2001;595-602.
11. Song J., Pfeffer L.M., Foster D.A. v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine. Mol. Cell. Biol. 11:1991;4903-4908.
12. Wyke A.W., Cook S.J., MacNulty E.E., Wakelam M.J. v-Src induces elevated levels of diglyceride by stimulation of phosphatidylcholine hydrolysis. Cell. Signal. 4:1992;267-274.
13. Chalifa-Caspi V., Eli Y., Liscovitch M. Kinetic analysis in mixed micelles of partially purified rat brain phospholipase D activity and its activation by phosphatidylinositol 4,5-bisphosphate. Neurochem. Res. 23:1998;589-599.
14. Green D.R. Apoptotic pathways: the roads to ruin. Cell. 94:1998;695-698.
15. Shen Y., Zheng Y., Foster D.A. Phospholipase D2 stimulates cell protrusion in v-Src-transformed cells. Biochem. Biophys. Res. Commun. 293:2002;201-206.
16. Kam Y., Exton J.H. Dimerization of phospholipase D isozymes. Biochem. Biophys. Res. Commun. 290:2002;375-380.