Cation exchange separation of 61Cu2+ from natCo targets and preparation of 61Cu-DOTA-HSA as a blood pool agent

Applied Radiation and Isotopes

Volumn 67, Issue 4, 2009, Pages 511-515

  Hao, Guiyang ^a   Fukumura, Toshimitsu ^a   Nakao, Ryuji ^a   Suzuki, Hisashi ^a   Szelecsényi, Ferenc ^b   Kovács, Zoltan ^b   Suzuki, Kazutoshi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b INSTITUTE OF NUCLEAR RESEARCH ATOMKI   (Hungary)

Author keywords

61Cu; Cation exchange resin; DOTA; HSA; Isolation

Indexed keywords

61CU; CATION EXCHANGE RESIN; DOTA; HSA; ISOLATION;

ACETONE; BLOOD; ION EXCHANGE RESINS; POSITIVE IONS; RESINS;

COPPER;

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; ACETONE; CATION EXCHANGE RESIN; CHLORIDE; COBALT 60; CUPRIC ION; HUMAN SERUM ALBUMIN;

ARTICLE; BLOOD; CATION EXCHANGE; PRIORITY JOURNAL; PURIFICATION; SEPARATION TECHNIQUE;

AUTORADIOGRAPHY; CATION EXCHANGE RESINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COBALT; COPPER RADIOISOTOPES; GATED BLOOD-POOL IMAGING; ORGANOMETALLIC COMPOUNDS; SERUM ALBUMIN; TISSUE DISTRIBUTION;

EID: 59949089197     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2008.12.004     Document Type: Article

References (11)

1. 64Cu-labeled RGD peptide. Bioconjugate Chem. 15 (2004) 41-49
2. 61Cu-ATSM. J. Labelled Compd. Radiopharm. 46 (2003) S286
3. 61Cu-ATSM. Radiochim. Acta 92 (2004) 209-214
4. Hoffend J., Mier W., Schuhmacher J., Schmidt K., Dimitrakopoulou-Strauss A., Strauss L., Eisenhut M., Kinscherf R., and Haberkorn U. Gallium-68-DOTA-albumin as a PET blood-pool marker: experimental evaluation in vivo. Nucl. Med. Biol. 32 3 (2005) 287-292
5. Lewis M.R., Kao J.Y., Anderson A.J., Shively J.E., and Raubitschek A. An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA. Bioconjugate Chem. 12 2 (2001) 320-324
6. Mathias C.J., Welch M.J., Green M.A., Diril H., Meares C.F., Gropler R.J., and Bergmann S.R. In vivo comparison of copper blood-pool agents: potential radiopharmaceuticals for use with copper-62. J. Nucl. Med. 32 (1991) 475-480
7. McDonald D.M., and Choyke P.L. Imaging of angiogenesis: from microscope to clinic. Nat. Med. 9 (2003) 713-725
8. Meares C.F., McCall M.J., Reardan D.T., Goodwin D.A., Diamanti C.I., and McTigue M. Conjugation of antibodies with bifunctional chelating agents: isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions. Anal. Biochem. 142 1 (1984) 68-78
9. Mier W., Hoffend J., Krämer S., Schuhmacher J., Hull W.E., Eisenhut M., and Haberkorn U. Conjugation of DOTA using isolated phenolic active esters: the labeling and biodistribution of albumin as blood pool marker. Bioconjugate Chem. 16 1 (2005) 237-240
10. Penefsky H.S. A centrifuged-column procedure for the measurement of ligand binding by beef heart F1. Methods Enzymol. 56 (1979) 527-530
11. Strelow F.W.E., Victor A.H., Van Zyl C.R., and Eloff C. Distribution coefficients and cation exchange behavior of elements in hydrochloric acid-acetone. Anal. Chem. 43 7 (1971) 870-876