Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects

Journal of Toxicological Sciences

Volumn 34, Issue 1, 2009, Pages 89-97

  Kimura, Yukiko ^a   Nishimura, Fusae T ^a   Abe, Shuntaro ^b   Fukunaga, Tatsushige ^c   Tanii, Hideji ^a   Saijoh, Kiyofumi ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Tokyo Medical Examiner's Office   (Japan)

Author keywords

Alcohol dehydrogenase 4; Ethanol metabolism; HepG2; Polymorphism; Transcriptional activity

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 4; ALDEHYDE DEHYDROGENASE ISOENZYME 2; GLUTAMINE; LYSINE; UNCLASSIFIED DRUG;

ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL METABOLISM; ALCOHOL OXIDATION; ALLELE; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; FEMALE; GENE ACTIVITY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ANALYSIS; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; INGESTION; JAPANESE; MALE; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTION REGULATION;

EID: 59949088859     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.89     Document Type: Article

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