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He Y.Q., Zhang L., Jiang B.L., Zhang Z.C., Xu R.Q., Tang D.J., Qin J., Jiang W., Zhang X., Liao J., et al. Comparative and functional genomics reveals genetic diversity and determinants of host specificity among reference strains and a large collection of Chinese isolates of the phytopathogen Xanthomonas campestris pv. campestris. Genome Biol 8 (2007) R218
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The bifunctional effector AvrXccC of Xanthomonas campestris pv. campestris requires plasma membrane-anchoring for host recognition
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Wang L., Tang X., and He C. The bifunctional effector AvrXccC of Xanthomonas campestris pv. campestris requires plasma membrane-anchoring for host recognition. Mol Plant Pathol 8 (2007) 491-501
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The type III secretion effector XopXccN of Xanthomonas campestris pv. campestris is required for full virulence
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Jiang B.-L., He Y.-Q., Cen W.-J., Wei H.-Y., Jiang G.-F., Jiang W., Hang X.-H., Feng J.-X., Lu G.-T., Tang D.-J., et al. The type III secretion effector XopXccN of Xanthomonas campestris pv. campestris is required for full virulence. Res Microbiol 159 (2008) 216-220
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Jiang, B.-L.1
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Göhre V., and Robatzek S. Breaking the barriers: microbial effector molecules subvert plant immunity. Annu Rev Phytopathol 46 (2008) 189-215
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The conserved Xanthomonas campestris pv. vesicatoria effector protein XopX is a virulence factor and suppresses host defense in Nicotiana benthamiana
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Metz M., Dahlbeck D., Morales C.Q., Al Sady B., Clark E.T., and Staskawicz B.J. The conserved Xanthomonas campestris pv. vesicatoria effector protein XopX is a virulence factor and suppresses host defense in Nicotiana benthamiana. Plant J 41 (2005) 801-814
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14
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The Pseudomonas syringae type III-secreted protein HopPtoD2 possesses protein tyrosine phosphatase activity and suppresses programmed cell death in plants
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Espinosa A., Guo M., Tam V.C., Fu Z.Q., and Alfano J.R. The Pseudomonas syringae type III-secreted protein HopPtoD2 possesses protein tyrosine phosphatase activity and suppresses programmed cell death in plants. Mol Microbiol 49 (2003) 377-387
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Espinosa, A.1
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Underwood W., Zhang S., and He S.Y. The Pseudomonas syringae type III effector tyrosine phosphatase HopAO1 suppresses innate immunity in Arabidopsis thaliana. Plant J 52 (2007) 658-672
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16
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34548671163
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New type III effectors from Xanthomonas campestris pv. vesicatoria trigger plant reactions dependent on a conserved N-myristoylation motif
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Thieme F., Szczesny R., Urban A., Kirchner O., Hause G., and Bonas U. New type III effectors from Xanthomonas campestris pv. vesicatoria trigger plant reactions dependent on a conserved N-myristoylation motif. Mol Plant-Microbe Interact 20 (2007) 1250-1261
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Thieme, F.1
Szczesny, R.2
Urban, A.3
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Bonas, U.6
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17
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33947416963
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The HopX (AvrPphE) family of Pseudomonas syringae type III effectors require a catalytic triad and a novel N-terminal domain for function
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Nimchuk Z.L., Fisher E.J., Desveaux D., Chang J.H., and Dangl J.L. The HopX (AvrPphE) family of Pseudomonas syringae type III effectors require a catalytic triad and a novel N-terminal domain for function. Mol Plant-Microbe Interact 20 (2007) 346-357
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18
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57749115920
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The paper showed that XopD contains, in addition to the known SUMO protease domain, a helix-loop-helix domain and two EAR motifs for DNA binding and repression of defense-/senescence-associated genes, respectively. The authors demonstrated that all three activities of the modular XopD protein contribute to its virulence function, that is, promotion of bacterial growth in tomato and delay of disease symptoms.
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Kim J.G., Taylor K.W., Hotson A., Keegan M., Schmelz E.A., and Mudgett M.B. XopD SUMO protease affects host transcription, promotes pathogen growth, and delays symptom development in Xanthomonas-infected tomato leaves. Plant Cell 20 (2008) 1915-1929. The paper showed that XopD contains, in addition to the known SUMO protease domain, a helix-loop-helix domain and two EAR motifs for DNA binding and repression of defense-/senescence-associated genes, respectively. The authors demonstrated that all three activities of the modular XopD protein contribute to its virulence function, that is, promotion of bacterial growth in tomato and delay of disease symptoms.
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Kim, J.G.1
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19
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Hotson A., Chosed R., Shu H., Orth K., and Mudgett M.B. Xanthomonas type III effector XopD targets SUMO-conjugated proteins in planta. Mol Microbiol 50 (2003) 377-389
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Hotson, A.1
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Mudgett, M.B.5
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Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases
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The authors solved the XopD crystal structure and used it together with sequence alignments and enzyme assays to elucidate determinants of XopD substrate specificity.
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Chosed R., Tomchick D.R., Brautigam C.A., Mukherjee S., Negi V.S., Machius M., and Orth K. Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases. J Biol Chem 282 (2007) 6773-6782. The authors solved the XopD crystal structure and used it together with sequence alignments and enzyme assays to elucidate determinants of XopD substrate specificity.
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Chosed, R.1
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Negi, V.S.5
Machius, M.6
Orth, K.7
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21
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Novatchkova M., Budhiraja R., Coupland G., Eisenhaber F., and Bachmair A. SUMO conjugation in plants. Planta 220 (2004) 1-8
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22
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Roden J., Eardley L., Hotson A., Cao Y., and Mudgett M.B. Characterization of the Xanthomonas AvrXv4 effector, a SUMO protease translocated into plant cells. Mol Plant-Microbe Interact 17 (2004) 633-643
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Roden, J.1
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23
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0034711403
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Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease
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Orth K., Xu Z., Mudgett M.B., Bao Z.Q., Palmer L.E., Bliska J.B., Mangel W.F., Staskawicz B., and Dixon J.E. Disruption of signaling by Yersinia effector YopJ, a ubiquitin-like protein protease. Science 290 (2000) 1594-1597
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Orth, K.1
Xu, Z.2
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Bliska, J.B.6
Mangel, W.F.7
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Dixon, J.E.9
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24
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27944471038
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Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation
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Zhou H., Monack D.M., Kayagaki N., Wertz I., Yin J., Wolf B., and Dixit V.M. Yersinia virulence factor YopJ acts as a deubiquitinase to inhibit NF-κB activation. J Exp Med 202 (2005) 1327-1332
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Zhou, H.1
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Dixit, V.M.7
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25
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YopJ targets TRAF proteins to inhibit TLR-mediated NF-κB, MAPK and IRF3 signal transduction
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This study showed that the Yersinia effector YopJ inhibits innate immune responses downstream of Toll-like receptors by the inhibition of TRAF3 and TRAF6 ubiquitination. The authors provide a very good and critical discussion of the different YopJ activities.
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Sweet C.R., Conlon J., Golenbock D.T., Goguen J., and Silverman N. YopJ targets TRAF proteins to inhibit TLR-mediated NF-κB, MAPK and IRF3 signal transduction. Cell Microbiol 9 (2007) 2700-2715. This study showed that the Yersinia effector YopJ inhibits innate immune responses downstream of Toll-like receptors by the inhibition of TRAF3 and TRAF6 ubiquitination. The authors provide a very good and critical discussion of the different YopJ activities.
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Cell Microbiol
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Sweet, C.R.1
Conlon, J.2
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26
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33744457909
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Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation
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The work demonstrated that YopJ acts as acetyltransferase and blocks phosphorylation, and thereby activation, of a MAPK kinase by acetylation of critical residues in the activation loop. This revealed a novel mechanism of interference with host cell signaling which might be representative for other members of the YopJ/AvrRxv family.
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Mukherjee S., Keitany G., Li Y., Wang Y., Ball H.L., Goldsmith E.J., and Orth K. Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation. Science 312 (2006) 1211-1214. The work demonstrated that YopJ acts as acetyltransferase and blocks phosphorylation, and thereby activation, of a MAPK kinase by acetylation of critical residues in the activation loop. This revealed a novel mechanism of interference with host cell signaling which might be representative for other members of the YopJ/AvrRxv family.
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Science
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Mukherjee, S.1
Keitany, G.2
Li, Y.3
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Ball, H.L.5
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Orth, K.7
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27
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A conserved carboxylesterase is a SUPPRESSOR OF AVRBST-ELICITED RESISTANCE in Arabidopsis
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The authors identified an Arabidopsis carboxylesterase, SOBER1, which inhibits the AvrBsT-elicited HR dependent on its enzymatic activity. This raises the possibility that SOBER1 works antagonistically to AvrBsT on a common plant substrate.
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Cunnac S., Wilson A., Nuwer J., Kirik A., Baranage G., and Mudgett M.B. A conserved carboxylesterase is a SUPPRESSOR OF AVRBST-ELICITED RESISTANCE in Arabidopsis. Plant Cell 19 (2007) 688-705. The authors identified an Arabidopsis carboxylesterase, SOBER1, which inhibits the AvrBsT-elicited HR dependent on its enzymatic activity. This raises the possibility that SOBER1 works antagonistically to AvrBsT on a common plant substrate.
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Plant Cell
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Cunnac, S.1
Wilson, A.2
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Baranage, G.5
Mudgett, M.B.6
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28
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35548942766
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A bacterial effector acts as a plant transcription factor and induces a cell size regulator
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The paper showed for the first time that a bacterial type III effector binds directly to a specific plant promoter element leading to modification of host gene expression. AvrBs3 induces cell hypertrophy in pepper by transcriptional activation of a key regulator gene, UPA20.
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Kay S., Hahn S., Marois E., Hause G., and Bonas U. A bacterial effector acts as a plant transcription factor and induces a cell size regulator. Science 318 (2007) 648-651. The paper showed for the first time that a bacterial type III effector binds directly to a specific plant promoter element leading to modification of host gene expression. AvrBs3 induces cell hypertrophy in pepper by transcriptional activation of a key regulator gene, UPA20.
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Science
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Kay, S.1
Hahn, S.2
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29
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Plant-pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene
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The authors showed the direct transcriptional activation of the suicide gene Bs3 encoding a putative flavin monooxygenase by AvrBs3. Variation of the AvrBs3-responsive promoter element in the Bs3-E allele changes recognition specificity and results in inducibility by an AvrBs3 repeat deletion derivative.
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Römer P., Hahn S., Jordan T., Strauß T., Bonas U., and Lahaye T. Plant-pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene. Science 318 (2007) 645-648. The authors showed the direct transcriptional activation of the suicide gene Bs3 encoding a putative flavin monooxygenase by AvrBs3. Variation of the AvrBs3-responsive promoter element in the Bs3-E allele changes recognition specificity and results in inducibility by an AvrBs3 repeat deletion derivative.
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Science
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Römer, P.1
Hahn, S.2
Jordan, T.3
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Lahaye, T.6
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30
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The type III effectors HsvG and HsvB of gall-forming Pantoea agglomerans determine host specificity and function as transcriptional activators
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This study showed that the type III effectors HsvG and HsvB from Pantoea agglomerans determine specificity of gall formation on gypsophila and beet, respectively. Both effectors localize to the plant cell nucleus and act as transcriptional activators in yeast. For HsvG, the authors identified a consensus DNA binding site in vitro. This is the first report on putative TAL effectors outside of the AvrBs3 family.
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Nissan G., Manulis-Sasson S., Weinthal D., Mor H., Sessa G., and Barash I. The type III effectors HsvG and HsvB of gall-forming Pantoea agglomerans determine host specificity and function as transcriptional activators. Mol Microbiol 61 (2006) 1118-1131. This study showed that the type III effectors HsvG and HsvB from Pantoea agglomerans determine specificity of gall formation on gypsophila and beet, respectively. Both effectors localize to the plant cell nucleus and act as transcriptional activators in yeast. For HsvG, the authors identified a consensus DNA binding site in vitro. This is the first report on putative TAL effectors outside of the AvrBs3 family.
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Nissan, G.1
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El Yacoubi B., Brunings A.M., Yuan Q., Shankar S., and Gabriel D.W. In planta horizontal transfer of a major pathogenicity effector gene. Appl Environ Microbiol 73 (2007) 1612-1621
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Al-Saadi A., Reddy J.D., Duan Y.P., Brunings A.M., Yuan Q., and Gabriel D.W. All five host-range variants of Xanthomonas citri carry one pthA homolog with 17.5 repeats that determines pathogenicity on citrus, but none determine host-range variation. Mol Plant-Microbe Interact 20 (2007) 934-943
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