Influences of urinary pH on the pharmacokinetics of three amphetamine-type stimulants using a new high-performance liquid chromatographic method

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 728-738

  Wang, Ling ^a   Feng, Fang ^a   Xue, Quan Wang ^a   Zhu, Lan ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Amphetamine type stimulants; Analysis; Elimination; Fenfluramine; High performance liquid chromatography; Pharmacokinetics; Phenylpropanolamine; Pseudoephedrine; Renal reabsorption; Urinary pH

Indexed keywords

9,10 ANTHRAQUINONE 2 SULFONYLCHLORIDE; ANTHRAQUINONE DERIVATIVE; FENFLURAMINE; PHENYLPROPANOLAMINE; PSEUDOEPHEDRINE; UNCLASSIFIED DRUG; AMMONIUM CHLORIDE; BICARBONATE; CENTRAL STIMULANT AGENT;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; RAT; REACTION ANALYSIS; TIME TO MAXIMUM PLASMA CONCENTRATION; URINE PH; VALIDATION PROCESS; ANIMAL; CHEMISTRY; FEASIBILITY STUDY; ORAL DRUG ADMINISTRATION; PH; REPRODUCIBILITY; SPRAGUE DAWLEY RAT; URINE; VALIDATION STUDY;

ADMINISTRATION, ORAL; AMMONIUM CHLORIDE; ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEASIBILITY STUDIES; FENFLURAMINE; HYDROGEN-ION CONCENTRATION; MALE; PHENYLPROPANOLAMINE; PSEUDOEPHEDRINE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SODIUM BICARBONATE; URINE;

EID: 59849114024     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21438     Document Type: Article

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