Fast LC-MS/MS method for the determination of amphetamine, methamphetamine, MDA, MDMA, MDEA, MBDB and PMA in urine

Forensic Science International

Volumn 171, Issue 1, 2007, Pages 44-51

  Concheiro, Marta ^a   Simões, Susana Maria dos Santos Sadler ^b   Quintela, Óscar ^a   de Castro, Ana ^a   Dias, Mário João Rodrigues ^b   Cruz, Angelines ^a   López Rivadulla, Manuel ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b INSTITUTO NACIONAL DE MEDICINA LEGAL E CIÊNCIAS FORENSES   (Portugal)

Author keywords

Amphetamine; LC MS MS; MDMA; PMA; Urine

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; 4 METHOXYAMPHETAMINE; AMINE; AMPHETAMINE; METHAMPHETAMINE; N ETHYL 3,4 METHYLENEDIOXYAMPHETAMINE; N METHYLBENZODIOXAZOYLBUTANAMINE; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; URINALYSIS; VALIDATION PROCESS;

EID: 34547597375     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2006.10.004     Document Type: Article

References (47)

1. Drummer O.H., and Odell M. The Forensic Pharmacology of Drugs of Abuse (2001), Arnold, London
2. Nichols D.E. Differences between the mechanism of action of MDMA, MBDB, and the classic hallucinogens. Identification of a new therapeutic class: entactogens. J. Psychoactive Drugs 18 (1986) 305-313
3. European Monitoring Centre for Drugs and Drug Addiction, Annual Report 2005. http://www.emcdda.eu.int/.
4. de la Torre R., Farré M., Navarro M., Pacifici R., Zuccaro P., and Pichini S. Clinical pharmacokinetics of amphetamine and related substances: monitoring in conventional and non-conventional matrices. Clin. Pharmacokinet. 43 (2004) 157-185
5. Verstraete A.G., and Heyden F.V. Comparison of the sensitivity and specificity of six immunoassays for the detection of amphetamines in urine. J. Anal. Toxicol. 29 (2005) 359-364
6. Gan B.K., Baugh D., Liu R.H., and Walia A.S. Simultaneous analysis of amphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in urine samples by solid-phase extraction, derivatization, and gas chromatography/mass spectrometry. J. Forensic Sci. 36 (1991) 1331-1341
7. Thurman E.M., Pedersen M.J., Stout R.L., and Martin T. Distinguishing sympathomimetic amines from amphetamine and methamphetamine in urine by gas chromatography/mass spectrometry. J. Anal. Toxicol. 16 (1992) 19-27
8. Dallakian P., Budzikiewicz H., and Brzezinka H. Detection and quantitation of amphetamine and methamphetamine: electron impact and chemical ionization with ammonia-comparative investigation on Shimadzu QP 5000 GC-MS system. J. Anal. Toxicol. 20 (1996) 255-261
9. Ensslin H.K., Kovar K.A., and Maurer H.H. Toxicological detection of the designer drug 3,4-methylenedioxyethylamphetamine (MDE, 'Eve') and its metabolites in urine by gas chromatography-mass spectrometry and fluorescence polarization immunoassay. J. Chromatogr. B 683 (1996) 189-197
10. Kronstrand R. Identification of N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB) in urine from drug users. J. Anal. Toxicol. 20 (1996) 512-516
11. Centini F., Masti A., and Barni Comparini I. Quantitative and qualitative analysis of MDMA, MDEA, methamphetamine and amphetamine in urine by headspace/solid phase microextraction (SPME) and GC/MS. Forensic Sci. Int. 83 (1996) 161-166
12. Kintz P. Excretion of MBDB and BDB in urine, saliva, and sweat following single oral administration. J. Anal. Toxicol. 21 (1997) 570-575
13. Hensley D., and Cody J.T. Simultaneous determination of amphetamine, methamphetamine, methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methylenedioxyethylamphetamine (MDEA) enantiomers by GC-MS. J. Anal. Toxicol. 23 (1999) 518-523
14. Ugland H.G., Krogh M., and Rasmussen K.E. Automated determination of 'Ecstasy' and amphetamines in urine by SPME and capillary gas chromatography after propylchloroformate derivatization. J. Pharm. Biomed. Anal. 19 (1999) 463-475
15. Jurado C., Giménez M.P., Soriano T., Menéndez M., and Repetto M. Rapid analysis of amphetamine, methamphetamine, MDA and MDMA in urine using solid-phase microextraction, direct on-fiber derivatization, and analysis by GC-MS. J. Anal. Toxicol. 24 (2000) 11-16
16. Pizarro N., Ortuño J., Farré M., Hernández-López C., Pujadas M., Llebaría A., Juglar J., Roset P.N., Mas M., Segura J., Camí J., and de la Torre R. Determination of MDMA and its metabolites in blood and urine by gas chromatography-mass spectrometry and análisis of enantiomers by capillary electrophoresis. J. Anal. Toxicol. 26 (2002) 157-165
17. Pellegrini M., Rosati F., Pacifici R., Zuccaro R., Romolo F.S., and López A. Rapid screening method for determination of Ecstasy and amphetamines in urine samples using gas chromatography-chemical ionisation mass spectrometry. J. Chromatogr. B 769 (2002) 243-251
18. Stout P.R., Horn C.K., and Klette K.L. Rapid simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylamphetamine in urine by solid-phase extraction and GC-MS: a method optimized for high-volume laboratories. J. Anal. Toxicol. 26 (2002) 253-261
19. Huang Z., and Zhang S. Confirmation of amphetamine, methamphetamine, MDA and MDMA in urine samples using disk solid-phase extraction and gas chromatography-mass spectrometry after immunoassay screening. J. Chromatogr. B 792 (2003) 241-247
20. Klette K.L., Jamerson M.H., Morris-Kukoski C.L., Kettle A.R., and Snyder J.J. Rapid simultaneous determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, and 3,4-methylenedioxyethylamphetamine. J. Anal. Toxicol. 29 (2005) 669-674
21. Kataoka H., Lor H.L., Pawliszyn J., and Simple. Rapid determination of amphetamine, methamphetamine, and their methylenedioxy derivatives in urine by automated in-tube solid-phase microextraction coupled with liquid chromatography-electrospray ionization mass spectrometry. J. Anal. Toxicol. 24 (2000) 257-265
22. Jenkins K.M., Young M.S., Mallet C.R., and Elian A.A. Mixed-mode solid phase extraction procedures for the determination of MDMA and metabolites in urine using LC-MS, LC-UV, or GC-NPD. J. Anal. Toxicol. 28 (2004) 50-58
23. Wu T.Y., and Fuh M.R. Determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3 4-methylenedioxyethylamohetamine, and 3,4-methylenedioxymethamphetamine in urine by online solid-phase extraction and ion-pairing liquid chromatography with detection by electrospray tandem mass spectrometry. Rapid Commun. Mass Spectrom. 19 (2005) 775-780
24. Bogusz M.J., Kala M., and Maier R.D. Determination of phenylisothiocyanate derivatives of amphetamine and its analogues in biological fluids by HPLC-APCI-MS or DAD. J. Anal. Toxicol. 21 (1997) 59-69
25. Nordgren H.K., and Beck O. Direct screening in urine for MDMA and MDA by liquid chromatography-tandem mass spectrometry. J. Anal. Toxicol. 27 (2003) 1-5
26. Deventer K., Van Eenoo P., and Delbeke F.T. Screening for amphetamine and amphetamine-type drugs in doping analysis by liquid chromatography/mass spectrometry. Rapid Commun. Mass Spectrom. 20 (2006) 877-882
27. Mortier K.A., Dams R., Lambert W.E., De Letter E.A., Van Calenbergh S., and De Leenheer A.P. Determination of paramethoxyamphetamine and other amphetamine-related designer drugs by liquid chromatography/sonic spray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 16 (2002) 865-870
28. Cristoni S., Bernardi L.R., Gerthoux P., Gonella E., and Mocarelli P. Surface-activated chemical ionization ion trap mass spectrometry in the analysis of amphetamines in diluted urine samples. Rapid Commun. Mass Spectrom. 18 (2004) 1847-1855
29. Bogusz M.J., Krüger K.D., and Maier R.D. Analysis of underivatized amphetamines and related phenethylamines with high-performance liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. J. Anal. Toxicol. 24 (2000) 77-84
30. Wood M., De Boeck G., Samyn N., Morris M., Cooper D.P., Maes R.A., and De Bruijn E.A. Development of a rapid and sensitive method for the quantitation of amphetamines in human plasma and oral fluid by LC-MS/MS. J. Anal. Toxicol. 27 (2003) 78-87
31. Hendrickson H.P., Milesi-Hallé A., Laurenzana E.M., and Owens S.M. Development of a liquid chromatography-mass spectrometric method for the determination of methamphetamine and amphetamine using small volumes of rat serum. J. Chromatogr. B 806 (2004) 81-87
32. Concheiro M., de Castro A., Quintela O., López-Rivadulla M., and Cruz A. Determination of drugs of abuse and their metabolites in human plasma by liquid chromatography-mass spectrometry: an application to 156 road fatalities. J. Chromatogr. B 832 (2006) 81-89
33. Sadeghipour F., and Veuthey J.-L. Sensitive and selective determination of methylenedioxylated amphetamines by high performance liquid chromatography with fluorimetric detection. J. Chromatogr. A 787 (1997) 137-143
34. Herráez-Hernández R., Campís-Falcó P., and Verdú-Andrés J. Sensitive determination of methylenedioxylated amphetamines by liquid chromatography. Analyst 126 (2001) 581-586
35. Clauwaert K., Van Bocxlaer J., De Letter E., Van Calenbergh S., Lambert W., and De Leenheer A. Determination of the designer drugs 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyehtylamphetamine, and 3,4-methylenedioxyamphetamine with HPLC and fluorescence detection in whole blood, serum, vitreous humor, and urine. Clin. Chem. 46 (2000) 1968-1977
36. da Costa J., and da Matta Chasin A. Determination of MDMA, MDEA and MDA in urine by high performance liquid chromatography with fluorescence detection. J. Chromatogr. B 811 (2004) 41-45
37. Tagliaro F., De Battisti Z., Groppi A., Nakahara Y., Scarcella D., Valentín R., and Marigo M. High sensitivity simultaneous determination in hair of the major constituents of ecstasy (3,4-methylenedioxymethamphetamine, 3,4-methylenedioxyamphetamine and 3,4-methylenedioxyethylamphetamine) by high-performance liquid chromatography with direct fluorescence detection. J. Chromatogr. B 723 (1999) 195-202
38. Kaddoumi A., Kikura-Hanajiri R., and Nakashima K. High-performance liquid chromatography determination of 3,4-methylenedioxymetamphetamine, methamphetamine and their metabolites in human hair using DIB-CI as a label. Biomed. Chromatogr. 18 (2004) 202-204
39. Mancinelli R., Gentilli S., Guiducci M., and Macchia T. Simple and reliable high-performance liquid chromatography fluorimetric procedure for the determination of amphetamine-derived designer drugs. J. Chromatogr. B 735 (1999) 243-253
40. Concheiro M., de Castro A., Quintela O., López-Rivadulla M., and Cruz A. Determination of MDMA, MDA, MDEA and MBDB in oral fluid using high performance liquid chromatography with native fluorescence detection. Forensic Sci. Int. 150 (2005) 221-226
41. Shah V.P., Mida K.K., Findlay J.W.A., Hill H.M., Hulse J.D., McGilveray J.J., McKay G., Miller K.J., Patnaik R.N., Powell M.L., Tonnelli A., Viswanattan C.T., and Jacobi A. Bioanalytical method validation-A revisit with a decade of progress. Pharm. Res. 17 (2002) 1551-1557
42. Peters F.T., and Maurer H.H. Bioanalytical method validation and its implications for forensic and clinical toxicology-a review. Accred. Qual. Assur. 7 (2002) 441-449
43. European Union Decision 2002/657/EC 17.8.2002. Off. J. Eur. Commun. 221 (2002) 8-36
44. Annesley T. Ion suppression in mass spectrometry. Clin. Chem. 49 (2003) 1041-1044
45. Matuszewski B.K., Constanzer M.L., and Chavez-Eng C.M. Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per milliliter concentrations. Anal. Chem. 70 (1998) 882-889
46. Bonfiglio R., King R.C., Olah T.V., and Merkle K. The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds. Rapid Commun. Mass Spectrom. 13 (1999) 1175-1185
47. Kunsman G.W., Levine B., Kuhlman J.J., Jones R.L., Hughes R.O., Fujiyama C.I., and Smith M.L. MDA-MDMA concentrations in urine specimens. J. Anal. Toxicol. 20 (1996) 517-521