Positive selection and expansion of cytomegalovirus-specific CD4 and CD8 T cells in sealed systems: Potential applications for adoptive cellular immunoreconstitution

Journal of Immunotherapy

Volumn 31, Issue 8, 2008, Pages 762-770

  Li Pira, Giuseppina ^a   Ivaldi, Federico ^a   Tripodi, Gino ^b   Martinengo, Marina ^b   Manca, Fabrizio ^c  

^a ADVANCED BIOTECHNOLOGY CENTER   (Italy)

^b Immunohematology Unit   (Italy)

^c G GASLINI INSTITUTE   (Italy)

Author keywords

Adoptive immunoreconstitution; Cytomegalovirus; Sealed culture systems; T cell lines

Indexed keywords

CYTOMEGALOVIRUS ANTIGEN PP65; GAMMA INTERFERON; POLITEF; CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; MATRIX PROTEIN; PEPTIDE LIBRARY; PHOSPHOPROTEIN; UNCLASSIFIED DRUG;

ADOPTIVE IMMUNOTHERAPY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL SELECTION; CONTROLLED STUDY; CYTOMEGALOVIRUS; HUMAN; HUMAN CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; CELL CULTURE; CELL LINE; CULTURE TECHNIQUE; IMMUNOLOGY; IMMUNOMAGNETIC SEPARATION; LYMPHOCYTE ACTIVATION; METABOLISM; TRANSPLANTATION;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL CULTURE TECHNIQUES; CELL LINE; CELLS, CULTURED; CYTOMEGALOVIRUS; HUMANS; IMMUNOMAGNETIC SEPARATION; IMMUNOTHERAPY, ADOPTIVE; LYMPHOCYTE ACTIVATION; PEPTIDE LIBRARY; PHOSPHOPROTEINS; VIRAL MATRIX PROTEINS;

EID: 59849107343     PISSN: 15249557     EISSN: None     Source Type: Journal    
DOI: 10.1097/CJI.0b013e3181826232     Document Type: Article

References (29)

1. Hibberd PL, Snydman DR. Cytomegalovirus infection in organ transplant recipients. Infect Dis Clin North Am. 1995;9:863-877.
2. Kovacs JA, Masur H. Opportunistic infections. In: De Vita TJ, Rosenberg SA, eds. AIDS Ethology, Diagnosis Treatment and Prevention. Philadelphia, PA: Joshua B. Lippincott; 1992:199-218.
3. Fujita Y, Rooney CM, Heslop HE. Adoptive cellular immunotherapy for EBV lymphoproliferative disease. Immunol Rev. 1997;157:217-222.
4. O'Reilly RJ, Lacerda JF, Lucas KG, et al. Biology and adoptive cell therapy of Epstein-Barr virus-associated lymphoproliferative disorders in recipients of marrow allografts. Immunol Rev. 1997;157:195-216.
5. Comoli P, De Palma R, Siena S, et al. Adoptive transfer of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T cells with in vitro antitumor activity boosts LMP2-specific immune response in a patient with EBV-related nasopharyngeal carcinoma. Ann Oncol. 2004;15:113-117.
6. Perruccio K, Tosti A, Burchielli E, et al. Transferring functional immune responses to pathogens after haploidentical hematopoietic transplantation. Blood. 2005;106:4397-4406.
7. Feuchtinger T, Matthes-Martin S, Richard C, et al. Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation. Br J Haematol. 2006;134:64-76.
8. Riddell SR, Greenberg PD. Principles for adoptive T-cell therapy of human viral diseases. Annu Rev Immunol. 1995;13:545-586.
9. Einsele H, Roosnek E, Rufer N. Infusion of cytomegalovirus (CMV)-specific T-cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood. 2002;99:3916-3922.
10. Peggs KS, Verfuerth S, Pizzey A, et al. Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines. Lancet. 2003;362:1375-1377.
11. Cobbold M, Khan N, Pourgheysari BA, et al. Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers. J Exp Med. 2005;202:379-386.
12. Brosterhus H, Brings S, Leyendeckers H, et al. Enrichment and detection of live antigen-specific CD4(+) and CD8(+) T-cells based on cytokine secretion. Eur J Immunol. 1999;29:4053-4059.
13. + T-cell lines for adoptive transfer into recipients of allogeneic stem cell transplants. Blood. 2004;103:3565-3572.
14. H peptides from the cytomegalovirus protein pp65 to design a peptide library for generation of CD4 T-cell lines for cellular immunoreconstitution. Int Immunol. 2004;16:635-642.
15. Li Pira G, Bottone L, Ivaldi F, et al. Generation of cytomegalovirus (CMV)-specific CD4 T-cell lines devoid of alloreactivity, by use of a mixture of CMV-phosphoprotein 65 peptides for reconstitution of the T helper repertoire. J Infect Dis. 2005;191:215-226.
16. Li Pira G, Ivaldi F, Bottone L, et al. High throughput functional microdissection of pathogen-specific T-cell immunity using antigen and lymphocyte arrays. J Immunol Methods. 2007;326:22-32.
17. Li Pira G, Ivaldi F, Bottone L, et al. Helper function of cytolytic lymphocytes: switching roles in the immune response. Eur J Immunol. 2007;37:66-77.
18. Li Pira G, Bottone L, Ivaldi F, et al. A sealed and unbreached system for purification, stimulation, and expansion of cytomegalovirus-specific human CD4 and CD8 T lymphocytes. Transfusion. 2006;46:2053-2062.
19. Diamond D, York J, Sun J-Y, et al. Development of a candidate HLA A*0201 restricted peptide-based vaccine against human cytomegalovirus infection. Blood. 1997;90:1751-1767.
20. Hammer MH, Meyer S, Brestrich G, et al. HLA type-independent generation of antigen-specific T-cells for adoptive immunotherapy. Eur J Immunol. 2005;35:2250-2258.
21. Szmania S, Gallowayn A, Bruorton M, et al. Isolation and expansion of cytomegalovirus-specific cytotoxic T lymphocytes from a single blood draw using dendritic cells and HLA-tetramers. Blood. 2001;98:505-512.
22. + T lymphocytes using dendritic cells pulsed with an A*0201-restricted peptide. Br J Haematol. 2001;1 13:479-482.
23. Kleihauer A, Grigoleit U, Hebart H, et al. Ex vivo generation of human cytomegalovirus specific cytotoxic T cells by peptide-pulsed dendritic cells. Br J Haematol. 2001;1 13:231-239.
24. Moss P, Rickinson A. Cellular immunotherapy for viral infection after HSC transplantation. Nat Rev Immunol. 2005;5:9-20.
25. Wilkie GM, Taylor C, Jones MM, et al. Establishment and characterization of a bank of cytotoxic T lymphocytes for immunotherapy of Epstein-Barr virus associated disease. J Immunother. 2004;27:309-316.
26. Riddell SR, Watanabe KS, Goodrich JM, et al. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T-cell clones. Science. 1992;257:238-241.
27. Walter EA, Greenberg PD, Gilbert MJ, et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med. 1995;333:1038-1044.
28. Sette A, Peters B. Immune epitope mapping in the post-genomic era: lessons for vaccine development. Curr Opin Immunol. 2007;19: 106-110.
29. Dander E, Li Pira G, Biagi E, et al. Characterization of migratory activity and cytokine profile of helper and cytotoxic CMV-specific T cell lines expanded by a selective peptide library. Exp Haematol. 2008;36:473-485.