A population pharmacokinetic turnover and surge-function model for describing melatonin biological rhythm in healthy male subjects

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 782-790

  Charles, Bruce ^a   Touitou, Yvan ^b   Selmaoui, Brahim ^b,c  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b SORBONNE UNIVERSITÉ   (France)

^c HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

Author keywords

Circadian; Melatonin; Mixed effects; Model; Pharmacokinetic; Turnover

Indexed keywords

MELATONIN;

ADULT; ALGORITHM; ARTICLE; CALCULATION; CIRCADIAN RHYTHM; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHARMACOKINETICS; POPULATION MODEL; POPULATION PHARMACOKINETIC MODELING; TURNOVER TIME; BIOLOGICAL MODEL; BLOOD; COMPUTER SIMULATION; REFERENCE VALUE; REPRODUCIBILITY;

ADULT; ALGORITHMS; CIRCADIAN RHYTHM; COMPUTER SIMULATION; HUMANS; MALE; MELATONIN; MODELS, BIOLOGICAL; PHARMACOKINETICS; REFERENCE VALUES; REPRODUCIBILITY OF RESULTS; YOUNG ADULT;

EID: 59849106580     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21407     Document Type: Article

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