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Ramharter, M, Kurth, F, Schreier, AC, Nemeth, J, Glasenapp, I, Belard, S, Schlie, M, Kammer, J, Koumba, PK, Cisse, B, Mordmuller, B, Lell, B, Issifou, S, Oeuvray, C, Fleckenstein, L, Kremsner, PG. Fixed-dose pyronaridine-artesunate combination for treatment of uncomplicated falciparum malaria in pediatric patients in Gabon. [Journal Article. Research Support, Non-U.S. Gov't] Journal of Infectious Diseases. 198(6):911-9, 2008 Sep 15.
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59849127645
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Our own estimation of the value of the Priority Review Voucher is based on the real development costs of the product Pyramax Pyronaridine-Artesunate, Using standard probabilities of success for each clinical phase for an anti-infective medicine, and a commercial cost of capital of 12, then we estimate that the voucher would repay the investments needed for all of Phase II and Phase III studies, including the CMC costs. For MMV this is a better description of the value, than giving a pure dollar number, given that the voucher is only useful many years after the clinical development is completed
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Our own estimation of the value of the Priority Review Voucher is based on the real development costs of the product Pyramax (Pyronaridine-Artesunate). Using standard probabilities of success for each clinical phase for an anti-infective medicine, and a commercial cost of capital of 12%, then we estimate that the voucher would repay the investments needed for all of Phase II and Phase III studies, including the CMC costs. For MMV this is a better description of the value, than giving a pure dollar number, given that the voucher is only useful many years after the clinical development is completed.
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42949139813
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Synthesis and Structure - Activity Relationships of 4-Pyridones as Potential Antimalarials
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Yeates, CL, Batchelor, JF, Capon, EC, Cheesman, NJ, Fry, M, Hudson, AT, Pudney, M, Trimming, H, Woolven, J, Bueno, JM, Chicharro, J, Fernández, E, Fiandor, JM, Gargallo-Viola, D, Gomez de las Heras, F, Herreros, E, León, ML. Synthesis and Structure - Activity Relationships of 4-Pyridones as Potential Antimalarials. Journal of Medicinal Chemistry; 2008; 51(9); 2845-2852.
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4344630762
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Identification of an antimalarial synthetic trioxolane drug development candidate
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59849103307
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The attrition rate of 28% from Phase I to launch for anti-infective medicines comes from the Centre for Medicines Research http://cmr.thomsonreuters.com/. We expect this number to fall over the next 10 years, as the number of medicines targeting unprecedented mechanisms increases.
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The attrition rate of 28% from Phase I to launch for anti-infective medicines comes from the Centre for Medicines Research http://cmr.thomsonreuters.com/. We expect this number to fall over the next 10 years, as the number of medicines targeting unprecedented mechanisms increases.
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A position paper of the criteria for the selection of partners in a combination therapy against malaria can be found at
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A position paper of the criteria for the selection of partners in a combination therapy against malaria can be found at http://www.mmv.org/ article.php3?id_article=27.
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Plasmodium is haploid for most of its lifecycle, making knock-outs more difficult. The machinery for interference RNA methods has not been conclusively identified in the parasite. More recently, progress has been made using siRNA against potential host targets. Rodriguez, CD, Hannus, M, Prudencio, M, Martin, C, Gonçalves, LA, Portugal, S, Epiphanio, S, Akinc, A, Hadwiger, P, Jahn-Hofmann, K, Röhl, I, Gemert, G-J, Frantich, J-F, Luty, AJF, Sauerwein, R, Mazier, D, Koteliansky, V, Vornlocher, H-P, Echeverin, CJ, Mota, MM. Host Scavenger Receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection. Cell Host & Microbe 4 271-282 2008.
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Plasmodium is haploid for most of its lifecycle, making knock-outs more difficult. The machinery for interference RNA methods has not been conclusively identified in the parasite. More recently, progress has been made using siRNA against potential host targets. Rodriguez, CD, Hannus, M, Prudencio, M, Martin, C, Gonçalves, LA, Portugal, S, Epiphanio, S, Akinc, A, Hadwiger, P, Jahn-Hofmann, K, Röhl, I, Gemert, G-J, Frantich, J-F, Luty, AJF, Sauerwein, R, Mazier, D, Koteliansky, V, Vornlocher, H-P, Echeverin, CJ, Mota, MM. Host Scavenger Receptor SR-BI plays a dual role in the establishment of malaria parasite liver infection. Cell Host & Microbe 4 271-282 2008.
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Grundner, C, Perrin, D, Hooft van Huijsduijnen, R, Swinnen, D, Gonzalez, J, Gee, CL, Wells, TN, Alber, T. Structural basis for selective inhibition of Mycobacterium tuberculosis protein tyrosine phosphatase PtpB. [Journal Article. Research Support, N.I.H., Extramural. Research Support, Non-U.S. Gov't. Research Support, U.S. Gov't, Non-P.H.S.] Structure. 15(4):499-509, 2007 Apr.
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Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy
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