Antimicrobial mechanisms of action;Mecanismos de acción de los antimicrobianos

Enfermedades Infecciosas y Microbiologia Clinica

Volumn 27, Issue 1, 2009, Pages 44-52

  Calvo, Jorge ^a   Martínez Martínez, Luis ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

Author keywords

Antimicrobial agents; Cell wall; Cytoplasmic membrane; DNA; Mechanism of action; Metabolic pathways; Protein synthesis

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; BACITRACIN; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE INHIBITOR; CARBAPENEM; CEPHALOSPORIN; CHLORAMPHENICOL; CYCLOSERINE; DAPTOMYCIN; FOSFOMYCIN; FUSIDIC ACID; KETOLIDE; LINCOSAMINE DERIVATIVE; MACROLIDE; MUREIDOMYCIN A; NITROFURAN; NITROIMIDAZOLE; OXAZOLIDINONE DERIVATIVE; POLYMYXIN; POLYPEPTIDE ANTIBIOTIC AGENT; PSEUDOMONIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; STREPTOGRAMIN; SULFANILAMIDE; TETRACYCLINE; TRIMETHOPRIM; UNINDEXED DRUG; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL WALL; BACTERIAL METABOLISM; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; CELL MEMBRANE; DRUG MECHANISM; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION;

ANTI-BACTERIAL AGENTS; BACTERIA; BACTERIAL PROTEINS; BETA-LACTAMASES; CELL MEMBRANE; CELL WALL; DNA DAMAGE; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; FOLIC ACID ANTAGONISTS; GENE EXPRESSION REGULATION, BACTERIAL; HUMANS;

EID: 59749088883     PISSN: 0213005X     EISSN: 15781852     Source Type: Journal    
DOI: 10.1016/j.eimc.2008.11.001     Document Type: Article

References (31)

1. Fleming A. On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. inlfuenzae. Brit J Exp Pathol 10 (1929) 226-236
2. Ausina Ruiz V, Prats Pastor G. Principales grupos de seres vivos con capacidad patógena para el hombre. En: Auxina Ruiz V, Moreno Guillén S, directores. Tratado SEIMC de enfermedades infecciosas y microbiología clínica. Madrid: Editorial Médica-Panamericana; 2006. p. 1-18.
3. Nikaido H. Molecular basis of bacterial outer membrane permeability revisited. Microbiol Mol Biol Rev 67 (2003) 593-656
4. Pascual Hernández A, Martínez-Martínez L, Almirante Gragera B, Miró Meda JM, editores. Actualización en antimicrobianos. Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. Barcelona: Ediciones Doyma; 2004.
5. a ed (2006), Prous Science, Barcelona
6. Martínez-Martínez L. Muerte bacteriana y heterorresistencia a los antimicrobianos. Enf Infecc Microbiol Clin 26 (2008) 481-484
7. Dover L.G., Alderwick L.J., Brown A.K., Futterer K., and Besra G.S. Regulation of cell wall synthesis and growth. Curr Mol Med 7 (2007) 247-276
8. Falagas M.E., Giannopoulou K.P., Kokolakis G.N., and Rafailidis P.I. Fosfomycin: use beyond urinary tract and gastrointestinal infections. Clin Infect Dis 46 (2008) 1069-1077
9. Allen N.E., and Nicas T.I. Mechanism of action of oritavancin and related glycopeptide antibiotics. FEMS Microbiol Rev 26 (2003) 511-532
10. Asbel L.E., and Levison M.E. Cephalosporins, carbapenems, and monobactams. Infect Dis Clin North Am 14 (2000) 435-447
11. Sauvage E., Kerff F., Terrak M., Ayala J.A., and Charlier P. The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis. FEMS Microbiol Rev 32 (2008) 234-258 Fe de errores en: FEMS Microbiol Rev. 2008;32:556
12. Bayles K.W. The bactericidal action of penicillin: new clues to an unsolved mystery. Trends Microbiol 8 (2000) 274-278
13. Henriques Normark B., and Normark S. Antibiotic tolerance in pneumococci. Clin Microbiol Infect 8 (2002) 613-622
14. Georgopapadakou N.H. Beta-lactamase inhibitors: evolving compounds for evolving resistance targets. Expert Opin Investig Drugs 13 (2004) 1307-1318
15. Li J., Nation R.L., Turnidge J.D., Milne R.W., Coulthard K., Rayner C.R., et al. Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. Lancet Infect Dis 6 (2006) 589-601
16. Kanafani Z.A., and Corey G.R. Daptomycin: a rapidly bactericidal lipopeptide for the treatment of Gram-positive infections. Expert Rev Anti Infect Ther 5 (2007) 177-184
17. Kaczanowska M., and Rydén-Aulin M. Ribosome biogenesis and the translation process in Escherichia coli. Microbiol Mol Biol Rev 71 (2007) 477-494
18. Ochsner U.A., Sun X., Jarvis T., Critchley I., and Janjic N. Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents. Expert Opin Investig Drugs 16 (2007) 573-593
19. Vara Prasad J.V. New oxazolidinones. Curr Opin Microbiol 10 (2007) 454-460
20. Mingeot-Leclercq M.P., Glupczynski Y., and Tulkens P.M. Aminoglycosides: activity and resistance. Antimicrob Agents Chemother 43 (1999) 727-737
21. Lacy M.K., Nicolau D.P., Nightingale C.H., and Quintiliani R. The pharmacodynamics of aminoglycosides. Clin Infect Dis 27 (1998) 23-27
22. Shlaes D.M. An update on tetracyclines. Curr Opin Investig Drugs 7 (2006) 167-171
23. Zhanel G.G., Homenuik K., Nichol K., Noreddin A., Vercaigne L., Embil J., et al. The glycylcyclines: a comparative review with the tetracyclines. Drugs 64 (2004) 63-88
24. Spízek J., and Rezanka T. Lincomycin, clindamycin and their applications. Appl Microbiol Biotechnol 64 (2004) 455-464
25. Retsema J., and Fu W. Macrolides: structures and microbial targets. Int J Antimicrob Agents 18 Suppl 1 (2001) S3-S10
26. Nilius A.M., and Ma Z. Ketolides: the future of the macrolides?. Curr Opin Pharmacol 2 (2002) 493-500
27. Blondeau J.M., and Sanche S.E. Quinupristin/dalfopristin. Expert Opin Pharmacother 3 (2002) 1341-1364
28. Villain-Guillot P., Bastide L., Gualtieri M., and Leonetti J.P. Progress in targeting bacterial transcription. Drug Discov Today 12 (2007) 200-208
29. Hooper D.C. Mechanisms of action of antimicrobials: focus on fluoroquinolones. Clin Infect Dis 32 Suppl 1 (2001) S9-S15
30. Drlica K., Malik M., Kerns R.J., and Zhao X. Quinolone-mediated bacterial death. Antimicrob Agents Chemother 52 (2008) 385-392
31. Masters P.A., O'Bryan T.A., Zurlo J., Miller D.Q., and Joshi N. Trimethoprim-sulfamethoxazole revisited. Arch Intern Med 163 (2003) 402-410