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Volumn 3, Issue 1, 2009, Pages 283-293

Histological features of early hepatocellular carcinomas and their developmental process: For daily practical clinical application

Author keywords

Biopsy diagnosis; Early hepatocellular carcinoma; Indistinct margin nodules; Stromal invasion

Indexed keywords

CYTOKERATIN 7;

EID: 59749086077     PISSN: 19360533     EISSN: 19360541     Source Type: Journal    
DOI: 10.1007/s12072-008-9107-9     Document Type: Review
Times cited : (32)

References (40)
  • 2
    • 0026027904 scopus 로고
    • Early stages of multistep hepatocarcinogenesis: Adenomatous hyperplasia and early hepatocellular carcinoma
    • doi: 10.1016/0046-8177(91)90039-R
    • Sakamoto M, Hirohashi S, Shimosato Y. Early stages of multistep hepatocarcinogenesis: Adenomatous hyperplasia and early hepatocellular carcinoma. Hum Pathol 1991;22:172-178. doi: 10.1016/0046-8177(91)90039-R
    • (1991) Hum Pathol , vol.22 , pp. 172-178
    • Sakamoto, M.1    Hirohashi, S.2    Shimosato, Y.3
  • 3
    • 0023134168 scopus 로고
    • Relationship of histologic grade of hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multiple different grades in single small HCC
    • Kenmochi K, Sugihara S, Kojiro M. Relationship of histologic grade of hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multiple different grades in single small HCC. Liver 1987;7:18-26
    • (1987) Liver , vol.7 , pp. 18-26
    • Kenmochi, K.1    Sugihara, S.2    Kojiro, M.3
  • 4
    • 0023179933 scopus 로고
    • Morphological clues for the diagnosis of small hepatocellular carcinomas
    • doi: 10.1007/BF00734509
    • Kondo F, Hirooka N, Wada K, Kondo Y. Morphological clues for the diagnosis of small hepatocellular carcinomas. Virchows Arch A Pathol Anat Histopathol 1987;411:15-21. doi: 10.1007/BF00734509
    • (1987) Virchows Arch A Pathol Anat Histopathol , vol.411 , pp. 15-21
    • Kondo, F.1    Hirooka, N.2    Wada, K.3    Kondo, Y.4
  • 5
    • 0029131938 scopus 로고
    • Pathomorphologic characteristics of small hepatocellular carcinoma: A special reference to small hepatocellular carcinoma with indistinct margins
    • Nakashima O, Sugihara S, Kage M, Kojiro M. Pathomorphologic characteristics of small hepatocellular carcinoma: A special reference to small hepatocellular carcinoma with indistinct margins. Hepatology 1995;22:101-105
    • (1995) Hepatology , vol.22 , pp. 101-105
    • Nakashima, O.1    Sugihara, S.2    Kage, M.3    Kojiro, M.4
  • 6
    • 17344368270 scopus 로고    scopus 로고
    • Early hepatocellular carcinoma as an entity with a high rate of surgical cure
    • doi: 10.1002/hep.510280511
    • Takayama T, Makuuchi M, Hirohashi S, Sakamoto M, Yamamoto J, Shimada K, et al. Early hepatocellular carcinoma as an entity with a high rate of surgical cure. Hepatology 1998;28:1241-1246. doi: 10.1002/hep.510280511
    • (1998) Hepatology , vol.28 , pp. 1241-1246
    • Takayama, T.1    Makuuchi, M.2    Hirohashi, S.3    Sakamoto, M.4    Yamamoto, J.5    Shimada, K.6
  • 7
    • 59749097396 scopus 로고
    • Early hepatocellular carcinoma; carcinogenesis, morphology and developmental fashion
    • Kondo F, Ebara M. Early hepatocellular carcinoma; carcinogenesis, morphology and developmental fashion. Shokakika Jpn 1992;16:409-417
    • (1992) Shokakika Jpn , vol.16 , pp. 409-417
    • Kondo, F.1    Ebara, M.2
  • 8
    • 59749099583 scopus 로고
    • Biopsy diagnosis of small and well differentiated hepatocellular carcinoma
    • Kondo F, Kondo Y, Ebara M, Ohto M. Biopsy diagnosis of small and well differentiated hepatocellular carcinoma. Pathol Clin Med Jpn 1993;11:943-951
    • (1993) Pathol Clin Med Jpn , vol.11 , pp. 943-951
    • Kondo, F.1    Kondo, Y.2    Ebara, M.3    Ohto, M.4
  • 9
    • 0024522383 scopus 로고
    • Biopsy diagnosis of well-differentiated hepatocellular carcinoma based on new morphologic criteria
    • doi: 10.1002/hep.840090516
    • Kondo F, Wada K, Nagato Y, Nakajima T, Kondo Y, Hirooka N, et al. Biopsy diagnosis of well-differentiated hepatocellular carcinoma based on new morphologic criteria. Hepatology 1989;9:751-755. doi: 10.1002/ hep.840090516
    • (1989) Hepatology , vol.9 , pp. 751-755
    • Kondo, F.1    Wada, K.2    Nagato, Y.3    Nakajima, T.4    Kondo, Y.5    Hirooka, N.6
  • 10
    • 0031732647 scopus 로고    scopus 로고
    • Histological features predicting malignant transformation of nonmalignant hepatocellular nodules: A prospective study
    • doi: 10.1016/S0016-5085(98)70093-9
    • Terasaki S, Kaneko S, Kobayashi K, Nonomura A, Nakanuma Y. Histological features predicting malignant transformation of nonmalignant hepatocellular nodules: A prospective study. Gastroenterology 1998;115:1216-1222. doi: 10.1016/S0016-5085(98)70093-9
    • (1998) Gastroenterology , vol.115 , pp. 1216-1222
    • Terasaki, S.1    Kaneko, S.2    Kobayashi, K.3    Nonomura, A.4    Nakanuma, Y.5
  • 11
    • 1242329815 scopus 로고    scopus 로고
    • Hepatocellular nodules in cirrhosis: Focus on diagnostic criteria on liver biopsy. A Western experience
    • Roncalli M. Hepatocellular nodules in cirrhosis: Focus on diagnostic criteria on liver biopsy. A Western experience. Liver Transpl 2004;10:S9-S15
    • (2004) Liver Transpl , vol.10
    • Roncalli, M.1
  • 12
    • 0033929139 scopus 로고    scopus 로고
    • Pathomorphologic study on the mechanism of fatty change in small hepatocellular carcinoma of humans
    • doi: 10.1016/S0168-8278(00)80369-4
    • Kutami R, Nakashima Y, Nakashima O, Shiota K, Kojiro M. Pathomorphologic study on the mechanism of fatty change in small hepatocellular carcinoma of humans. J Hepatol 2000;33:282-289. doi: 10.1016/S0168-8278(00)80369-4
    • (2000) J Hepatol , vol.33 , pp. 282-289
    • Kutami, R.1    Nakashima, Y.2    Nakashima, O.3    Shiota, K.4    Kojiro, M.5
  • 13
    • 0022930305 scopus 로고
    • Pathologic features of small hepatocellular carcinoma
    • Kondo Y, Kondo F, Wada K, Okabayashi A. Pathologic features of small hepatocellular carcinoma. Acta Pathol Jpn 1986;36:1149-1161
    • (1986) Acta Pathol Jpn , vol.36 , pp. 1149-1161
    • Kondo, Y.1    Kondo, F.2    Wada, K.3    Okabayashi, A.4
  • 14
    • 0027984617 scopus 로고
    • Interstitial tumour cell invasion in small hepatocellular carcinoma. Evaluation in microscopic and low magnification views
    • doi: 10.1111/j.1440-1746.1994.tb01569.x
    • Kondo F, Kondo Y, Nagato Y, Tomizawa M, Wada K. Interstitial tumour cell invasion in small hepatocellular carcinoma. Evaluation in microscopic and low magnification views. J Gastroenterol Hepatol 1994;9:604-612. doi: 10.1111/j.1440-1746.1994.tb01569.x
    • (1994) J Gastroenterol Hepatol , vol.9 , pp. 604-612
    • Kondo, F.1    Kondo, Y.2    Nagato, Y.3    Tomizawa, M.4    Wada, K.5
  • 15
    • 0031059533 scopus 로고    scopus 로고
    • Stromal and blood vessel wall invasion in well-differentiated hepatocellular carcinoma
    • Nakano M, Saito A, Yamamoto M, Doi M, Takasaki K. Stromal and blood vessel wall invasion in well-differentiated hepatocellular carcinoma. Liver 1997;17:41-46
    • (1997) Liver , vol.17 , pp. 41-46
    • Nakano, M.1    Saito, A.2    Yamamoto, M.3    Doi, M.4    Takasaki, K.5
  • 16
    • 0032898465 scopus 로고    scopus 로고
    • Interstitial invasion of well-differentiated hepatocellular carcinoma and subsequent tumor growth
    • doi: 10.1046/j.1440-1827.1999.00848.x
    • Miyao Y, Ozaki D, Nagao T, Kondo Y. Interstitial invasion of well-differentiated hepatocellular carcinoma and subsequent tumor growth. Pathol Int 1999;49:208-213. doi: 10.1046/j.1440-1827.1999.00848.x
    • (1999) Pathol Int , vol.49 , pp. 208-213
    • Miyao, Y.1    Ozaki, D.2    Nagao, T.3    Kondo, Y.4
  • 17
    • 33847387209 scopus 로고    scopus 로고
    • Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules
    • doi: 10.1002/cncr.22460
    • Park YN, Kojiro M, Di Tommaso L, Dhillon AP, Kondo F, Nakano M, et al. Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules. Cancer 2007;109:915-923. doi: 10.1002/cncr.22460
    • (2007) Cancer , vol.109 , pp. 915-923
    • Park, Y.N.1    Kojiro, M.2    Di Tommaso, L.3    Dhillon, A.P.4    Kondo, F.5    Nakano, M.6
  • 18
    • 0344092205 scopus 로고
    • Pathology, diagnosis, and treatment for small liver cancer
    • In Tobe T, et al., editors. Tokyo: Springer-Verlag
    • Ohto M, Kondo F, Ebara M. Pathology, diagnosis, and treatment for small liver cancer. In Tobe T, et al., editors. Primary Liver Cancer in Japan. Tokyo: Springer-Verlag; 1992. 365-373
    • (1992) Primary Liver Cancer in Japan , pp. 365-373
    • Ohto, M.1    Kondo, F.2    Ebara, M.3
  • 19
    • 0024272295 scopus 로고
    • Large regenerative nodules and dysplastic nodules in cirrhotic livers: A histopathologic study
    • doi: 10.1002/hep.1840080636
    • Wada K, Kondo F, Kondo Y. Large regenerative nodules and dysplastic nodules in cirrhotic livers: A histopathologic study. Hepatology 1988;8:1684-1688. doi: 10.1002/hep.1840080636
    • (1988) Hepatology , vol.8 , pp. 1684-1688
    • Wada, K.1    Kondo, F.2    Kondo, Y.3
  • 20
    • 0029155354 scopus 로고
    • Terminology of nodular hepatocellular lesions
    • International Working Party
    • International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995;22:983-993
    • (1995) Hepatology , vol.22 , pp. 983-993
  • 21
    • 0025043924 scopus 로고
    • Histological features and clinical course of large regenerative nodules: Evaluation of their precancerous potentiality
    • doi: 10.1002/hep.1840120324
    • Kondo F, Ebara M, Sugiura N, Wada K, Kita K, Hirooka N, et al. Histological features and clinical course of large regenerative nodules: evaluation of their precancerous potentiality. Hepatology 1990;12:592-598. doi: 10.1002/hep.1840120324
    • (1990) Hepatology , vol.12 , pp. 592-598
    • Kondo, F.1    Ebara, M.2    Sugiura, N.3    Wada, K.4    Kita, K.5    Hirooka, N.6
  • 22
    • 0026697979 scopus 로고
    • Macroregenerative nodules and hepatocellular carcinoma in forty-four sequential adult liver explants with cirrhosis
    • doi: 10.1002/hep.1840160416
    • Theise ND, Schwartz M, Miller C, Thung SN. Macroregenerative nodules and hepatocellular carcinoma in forty-four sequential adult liver explants with cirrhosis. Hepatology 1992;16:949-955. doi: 10.1002/hep.1840160416
    • (1992) Hepatology , vol.16 , pp. 949-955
    • Theise, N.D.1    Schwartz, M.2    Miller, C.3    Thung, S.N.4
  • 23
    • 0028898433 scopus 로고
    • Macroregenerative nodules in a series of adult cirrhotic liver explants: Issues of classification and nomenclature
    • Hytiroglou P, Theise ND, Schwartz M, Mor E, Miller C, Thung SN. Macroregenerative nodules in a series of adult cirrhotic liver explants: issues of classification and nomenclature. Hepatology 1995;21:703-708
    • (1995) Hepatology , vol.21 , pp. 703-708
    • Hytiroglou, P.1    Theise, N.D.2    Schwartz, M.3    Mor, E.4    Miller, C.5    Thung, S.N.6
  • 24
    • 7744221846 scopus 로고    scopus 로고
    • Nodular lesions associated with abnormal liver circulation
    • doi: 10.1159/000078479
    • Kondo F, Koshima Y, Ebara M. Nodular lesions associated with abnormal liver circulation. Intervirology 2004;47:277-287. doi: 10.1159/000078479
    • (2004) Intervirology , vol.47 , pp. 277-287
    • Kondo, F.1    Koshima, Y.2    Ebara, M.3
  • 25
    • 33947396135 scopus 로고    scopus 로고
    • Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis
    • doi: 10.1002/hep.21531
    • Di Tommaso L, Franchi G, Park YN, Fiamengo B, Destro A, Morenghi E, et al. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 2007;45:725-734. doi: 10.1002/hep.21531
    • (2007) Hepatology , vol.45 , pp. 725-734
    • Di Tommaso, L.1    Franchi, G.2    Park, Y.N.3    Fiamengo, B.4    Destro, A.5    Morenghi, E.6
  • 26
    • 0037223571 scopus 로고    scopus 로고
    • Expression profiling in multistage hepatocarcinogenesis: Identification of HSP70 as a molecular marker of early hepatocellular carcinoma
    • doi: 10.1053/jhep.2003.50022
    • Chuma M, Sakamoto M, Yamazaki K, Ohta T, Ohki M, Asaka M, et al. Expression profiling in multistage hepatocarcinogenesis: Identification of HSP70 as a molecular marker of early hepatocellular carcinoma. Hepatology 2003;37:198-207. doi: 10.1053/jhep.2003.50022
    • (2003) Hepatology , vol.37 , pp. 198-207
    • Chuma, M.1    Sakamoto, M.2    Yamazaki, K.3    Ohta, T.4    Ohki, M.5    Asaka, M.6
  • 27
    • 0038786861 scopus 로고    scopus 로고
    • Glypican-3: A novel serum and histochemical marker for hepatocellular carcinoma
    • doi: 10.1016/S0016-5085(03)00689-9
    • Capurro M, Wanless IR, Sherman M, Deboer G, Shi W, Miyoshi E, et al. Glypican-3: A novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology 2003;125:89-97. doi: 10.1016/ S0016-5085(03)00689-9
    • (2003) Gastroenterology , vol.125 , pp. 89-97
    • Capurro, M.1    Wanless, I.R.2    Sherman, M.3    Deboer, G.4    Shi, W.5    Miyoshi, E.6
  • 28
    • 27944433471 scopus 로고    scopus 로고
    • The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma
    • Yamauchi N, Watanabe A, Hishinuma M, Ohashi K, Midorikawa Y, Morishita Y, et al. The glypican 3 oncofetal protein is a promising diagnostic marker for hepatocellular carcinoma. Mod Pathol 2005;18:1591-1598
    • (2005) Mod Pathol , vol.18 , pp. 1591-1598
    • Yamauchi, N.1    Watanabe, A.2    Hishinuma, M.3    Ohashi, K.4    Midorikawa, Y.5    Morishita, Y.6
  • 29
    • 33750430854 scopus 로고    scopus 로고
    • Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules
    • doi: 10.1097/01.pas.0000213323.97294.9a
    • Libbrecht L, Severi T, Cassiman D, Vander Borght S, Pirenne J, Nevens F, et al. Glypican-3 expression distinguishes small hepatocellular carcinomas from cirrhosis, dysplastic nodules, and focal nodular hyperplasia-like nodules. Am J Surg Pathol 2006;30:1405-1411. doi: 10.1097/01.pas.0000213323.97294.9a
    • (2006) Am J Surg Pathol , vol.30 , pp. 1405-1411
    • Libbrecht, L.1    Severi, T.2    Cassiman, D.3    Vander Borght, S.4    Pirenne, J.5    Nevens, F.6
  • 30
    • 0024350059 scopus 로고
    • Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations
    • doi: 10.1093/carcin/10.10.1917
    • Gebhardt R, Tanaka T, Williams GM. Glutamine synthetase heterogeneous expression as a marker for the cellular lineage of preneoplastic and neoplastic liver populations. Carcinogenesis 1989;10:1917-1923. doi: 10.1093/carcin/10.10.1917
    • (1989) Carcinogenesis , vol.10 , pp. 1917-1923
    • Gebhardt, R.1    Tanaka, T.2    Williams, G.M.3
  • 33
    • 0015854966 scopus 로고
    • Transection of the oesophagus for bleeding oesophageal varices
    • doi: 10.1002/bjs.1800600817
    • Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973;60:646-649. doi: 10.1002/bjs.1800600817
    • (1973) Br J Surg , vol.60 , pp. 646-649
    • Pugh, R.N.1    Murray-Lyon, I.M.2    Dawson, J.L.3    Pietroni, M.C.4    Williams, R.5
  • 34
    • 20344399151 scopus 로고    scopus 로고
    • Early hepatocellular carcinoma and dysplastic nodules
    • doi: 10.1055/s-2005-871193
    • Kojiro M, Roskams T. Early hepatocellular carcinoma and dysplastic nodules. Semin Liver Dis 2005;25:133-142. doi: 10.1055/s-2005-871193
    • (2005) Semin Liver Dis , vol.25 , pp. 133-142
    • Kojiro, M.1    Roskams, T.2
  • 35
    • 0031828832 scopus 로고    scopus 로고
    • Pathology of early HCC: Progression from early to advanced
    • Kojiro M. Pathology of early HCC: Progression from early to advanced. Hepatogastroenterology 1998;45:1203-1205
    • (1998) Hepatogastroenterology , vol.45 , pp. 1203-1205
    • Kojiro, M.1
  • 36
    • 0028787106 scopus 로고
    • CD34 expression in endothelial cells of small hepatocellular carcinoma: Its correlation with tumour progression and angiographic findings
    • doi: 10.1111/j.1440-1746.1995.tb01365.x
    • Maeda T, Adachi E, Kajiyama K, Takenaka K, Honda H, Sugimachi K, et al. CD34 expression in endothelial cells of small hepatocellular carcinoma: its correlation with tumour progression and angiographic findings. J Gastroenterol Hepatol 1995;10:650-654. doi: 10.1111/ j.1440-1746.1995.tb01365.x
    • (1995) J Gastroenterol Hepatol , vol.10 , pp. 650-654
    • Maeda, T.1    Adachi, E.2    Kajiyama, K.3    Takenaka, K.4    Honda, H.5    Sugimachi, K.6
  • 37
    • 0032955759 scopus 로고    scopus 로고
    • Vascularization of small hepatocellular carcinomas: Correlation with differentiation
    • doi: 10.1111/j.1478-3231.1999.tb00003.x
    • Nakashima Y, Nakashima O, Hsia CC, Kojiro M, Tabor E. Vascularization of small hepatocellular carcinomas: Correlation with differentiation. Liver 1999;19:12-18. doi: 10.1111/j.1478-3231.1999.tb00003.x
    • (1999) Liver , vol.19 , pp. 12-18
    • Nakashima, Y.1    Nakashima, O.2    Hsia, C.C.3    Kojiro, M.4    Tabor, E.5
  • 38
    • 0031782818 scopus 로고    scopus 로고
    • Investigators. A new prognostic system for hepatocellular carcinoma: A retrospective study of 435 patients
    • The Cancer of the Liver Italian Program (CLIP) doi: 10.1002/hep.510280322
    • The Cancer of the Liver Italian Program (CLIP) Investigators. A new prognostic system for hepatocellular carcinoma: A retrospective study of 435 patients. Hepatology 1998;28:751-755. doi: 10.1002/hep.510280322
    • (1998) Hepatology , vol.28 , pp. 751-755
  • 39
    • 0032879468 scopus 로고    scopus 로고
    • Prognosis of hepatocellular carcinoma: The BCLC staging classification
    • Llovet JM, Brú C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis 1999;19:329-338
    • (1999) Semin Liver Dis , vol.19 , pp. 329-338
    • Llovet, J.M.1    Brú, C.2    Bruix, J.3
  • 40
    • 10644225254 scopus 로고    scopus 로고
    • Validation of a new prognostic staging system for hepatocellular carcinoma: The JIS score compared with the CLIP score
    • doi: 10.1002/hep.20486
    • Kudo M, Chung H, Haji S, Osaki Y, Oka H, Seki T, et al. Validation of a new prognostic staging system for hepatocellular carcinoma: The JIS score compared with the CLIP score. Hepatology 2004;40:1396-1405. doi: 10.1002/hep.20486
    • (2004) Hepatology , vol.40 , pp. 1396-1405
    • Kudo, M.1    Chung, H.2    Haji, S.3    Osaki, Y.4    Oka, H.5    Seki, T.6


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