H2O2 increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo

Journal of Inherited Metabolic Disease

Volumn 32, Issue 1, 2009, Pages 86-94

  Chavan, B ^a   Beazley, W ^a   Wood, J M ^a   Rokos, H ^a,b   Ichinose, H ^c   Schallreuter, K U ^a,b  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b UNIVERSITY OF GREIFSWALD   (Germany)

^c FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN; HYDROGEN PEROXIDE; PHENYLALANINE; SAPROPTERIN; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME METABOLISM; EPIDERMIS; FEEDBACK SYSTEM; HUMAN; HUMAN CELL; OXIDATION; OXIDATIVE STRESS; PROTEIN FUNCTION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; VITILIGO;

BIOPSY; BIOPTERIN; CASE-CONTROL STUDIES; CATALASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; EPIDERMIS; FEEDBACK, BIOCHEMICAL; GTP CYCLOHYDROLASE; HUMANS; HYDROGEN PEROXIDE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; OXIDATION-REDUCTION; VITILIGO;

EID: 59749084066     PISSN: 01418955     EISSN: 15732665     Source Type: Journal    
DOI: 10.1007/s10545-008-0971-1     Document Type: Article

References (24)

1. Gerding HR, Vollmer E, Cremer-Bartels G, Rokos H, Krause K, Busse H (1993) Immunoenzymatic labeling of biopterin and neopterin in the pigment epithelium of bovine retina. Adv Exp Med Biol 338: 347-350.
2. Harada T, Kagamiyama H, Hatakeyama K (1993) Feedback regulation mechanism for the control of GTP cyclohydrolase activity. Science 260(5113): 1507-1509. doi: 10.1126/science.8502995.
3. 2 stress. J Invest Dermatol 122: 307-313. doi: 10.1046/ j.0022-202X.2004.22230.x.
4. Kalb VF Jr., Bernlohr RW (1977) A new spectrophotometric assay for protein in cell extracts. Anal Biochem 82: 362-371. doi: 10.1016/ 0003-2697(77)90173-7.
5. Kalivendi S, Hatakeyama K, Whitsett J, Konorev E, Kalyanaraman B, Vasquez-Vivar J (2005) Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide - a role for GFRP? Free Radic Biol Med 36: 481-491 doi: 10.1016/ j.freeradbiomed.2004.11.004.
6. Kiistala U (1968) A suction blister device for the separation of epidermis from dermis. J Invest Dermatol 50(2): 129-137.
7. Maita N, Okada K, Hatakeyama K, Hakoshima T (2002) Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP. Proc Natl Acad Sci U S A 99: 1212-1217. doi: 10.1073/pnas.022646999.
8. Maita N, Hatakeyama K, Okada K, Hakoshima T (2004) Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein. J Biol Chem 279(49): 51534-51540. doi: 10.1074/jbc.M409440200.
9. 2 -mediated oxidation of tetrahydrobiopterin: Fourier transform Raman investigations provide mechanistic implications for the enzymatic utilization and recycling of this essential co-factor. J Raman Spectrosc 33: 610-617.
10. 2 and pterin-6-carboxylic acid. Biochem Biophys Res Commun 292: 805-811. doi: 10.1006/bbrc.2002.6727.
11. Rokos H, Wood JM, Hasse S, Schallreuter K (2008) Identification of epidermal l-tryptophan and its oxidation products by in vivo FT-Raman spectroscopy further supports oxidative stress in patients with vitiligo. J Raman Spectrosc 39: 1214-1218. doi: 10.1002/jrs.1968.
12. Schallreuter KU (2007) Advances in melanocyte basic science research. Dermatol Clin 25: 283-291, vii. doi: 10.1016/j.det.2007.04.010.
13. Schallreuter KU, Elwary S (2007) Hydrogen peroxide regulates the cholinergic signal in a concentration dependent manner. Life Sci 80(24-25): 2221-2226. doi: 10.1016/j.lfs.2007.01.028.
14. Schallreuter KU, Wood JM, Pittelkow MR, et al (1994) Regulation of melanin biosynthesis in the human epidermis by tetrahydrobiopterin. Science 263(5152): 1444-1446. doi: 10.1126/science.8128228.
15. 2) accumulation in the epidermis of patients with vitiligo and its successful removal by a UVB-activated pseudocatalase. J Invest Dermatol Symp Proc 4: 91-96. doi: 10.1038/sj.jidsp.5640189.
16. 4 -dependent processes? J Invest Dermatol 116: 167-174. doi: 10.1046/j.1523-1747.2001.00220.x.
17. 2: A novel mechanism for increasing the l-tyrosine supply for melanogenesis in melanocytes. Biochem Biophys Res Commun 322: 88-92. doi: 10.1016/j.bbrc.2004.07.082.
18. 2: More evidence for oxidative stress in vitiligo. Biochem Biophys Res Commun 315: 502-508. doi: 10.1016/j.bbrc.2004.01.082.
19. Schallreuter KU, Chavan B, Rokos H, Hibberts N, Panske A, Wood JM (2005a) Decreased phenylalanine uptake and turnover in patients with vitiligo. Mol Genet Metab 86(Supplement 1): S27-33. doi: 10.1016/ j.ymgme.2005.07.023.
20. 2). Exp Dermatol 14: 155. doi: 10.1111/ j.0906-6705.2005.0266j.x.
21. Schallreuter KU, Rubsam K, Gibbons NC, et al (2008) Methionine Sulfoxide Reductases A and B Are Deactivated by Hydrogen Peroxide (H(2)O(2)) in the Epidermis of Patients with Vitiligo. J Invest Dermatol 128: 808-815.
22. Suzuki T, Ohye T, Inagaki H, Nagatsu T, Ichinose H (1999) Characterization of wild-type and mutants of recombinant human GTP cyclohydrolase I: Relationship to etiology of dopa-responsive dystonia. J Neurochem 73: 2510-2516. doi: 10.1046/j.1471-4159.1999.0732510.x.
23. 2. Biochem Biophys Res Commun 325: 1412-1417. doi: 10.1016/ j.bbrc.2004.10.185.
24. Yoneyama T, Hatakeyama K (2001) Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes. Protein Sci 10: 871-878. doi: 10.1110/ ps.38501.