Anaemia and neutropenia in a cohortof non-infected children of HIV-positive mothers;Anemia y neutropenia en una cohorte de niños no infectados hijos de madres positivas para el virus de la inmunodeficiencia humana

Anales de Pediatria

Volumn 69, Issue 6, 2008, Pages 533-543

  Fernandez Ibieta M ^a   Ramos Amador, J T ^a   Gonzalez Tome M I ^b   Guillen Martin S ^a   Bellon Cano J M ^c   Navarro Gomez M ^c   de Jose M I ^d   Beceiro, J ^e   Iglesias, E ^a   Rubio, B ^a   Relano Garrido P ^d   Santos, M J ^f   Martinez Guardia N ^f   Roa, M A ^g   Regidor, J ^h  

^a HOSPITAL UNIVERSITARIO DE GETAFE   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^d HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^e HOSPITAL UNIVERSITARIO PRÍNCIPE DE ASTURIAS   (Spain)

^f HOSPITAL SEVERO OCHOA   (Spain)

^g HOSPITAL DE MÓSTOLES   (Spain)

^h HOSPITAL UNIVERSITARIO FUNDACIÓN ALCORCÓN   (Spain)

Author keywords

Anaemia; Highly Active Antiretroviral Treatment (HAART); Human Immunodeficiency Virus (HIV); Mother to child transmission; Neutropenia

Indexed keywords

HEMOGLOBIN; PROTEINASE INHIBITOR; ZIDOVUDINE;

ANEMIA; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ETHNIC DIFFERENCE; FEMALE; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; INFANT; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; NEUTROPENIA; PLACENTAL TRANSFER; PREGNANT WOMAN; PREMATURITY; PRENATAL EXPOSURE; PREVALENCE; RISK ASSESSMENT; SPAIN; WITHDRAWAL SYNDROME;

EID: 59749083030     PISSN: 16954033     EISSN: 16959531     Source Type: Journal    
DOI: 10.1016/S1695-4033(08)75236-6     Document Type: Article

References (33)

1. Thorne C., Patel D., Fiore S., Peckham C., Newell M.L., and For the European Collaborative Study. Mother-to-child transmission of HIV infection in the era of highly active antiretroviral therapy. CID 40 (2005) 458-465
2. Warszawski J., Tubiana R., Le Chedenac J., Blanche S., Teglas J.P., Dollfus C., et al. Mother to-child HIV transmission despite antiretroviral therapy in the ANRS French Perinatal Cohort. AIDS 22 (2008) 289-299
3. Macassa E., Burgard M., Veber F., Picard C., Neven B., Malhaoui N., et al. Characteristics of HIV-infected children recently dignosed in Paris, France. Eur J Pediatr 165 (2006) 684-687
4. Fernández-Ibieta M., Ramos Amador J.T., Guillén Martín S., González-Tomé M.I., Navarro-Gómez M., Iglesias González-Nicolás E., et al. ¿Por qué se infectan aún niños con el virus de la inmunodeficiencia humana en España?. An Pediatr (Barc) 67 (2007) 109-115
5. Connor E.M., Sperling R.S., Gelber R., Kiselev P., Scout G., O'Sullivan M.J., et al. Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group. N Engl J Med 331 (1994) 1173-1180
6. King M., and American Academy of Pediatrics and Canadian Paediatric Society. Evaluation and Treatment of the Human Immunodeficiency Virus-1-Exposed Infant. Pediatrics 114 (2004) 497-505
7. BHIVA Guidelines for the Management of HIV Infection in Pregnant Women and the Prevention of Mother-to-Child Transmission. Disponible en: http://www.bhiva.org (último acceso 10-01-08).
8. Recomendaciones de la Secretaría del Plan Nacional sobre el SIDA (SPNS), el Grupo de Estudio de Sida (GeSida/SEIMC), la Sociedad Española de Ginecología y Obstetricia (SEGO) y la Asociación Española de Pediatría (AEP) para el seguimiento de la infección por el VIH con relación a la reproducción, el embarazo y la prevención de la transmisión vertical. Disponible en: http://www.gesida.org (último acceso 10/07/07).
9. Public Health Service Task Force Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-Infected Women for Maternal Health and Intervention to reduce perinatal HIV Transmission in the United States Revisado noviembre 2007. Disponible en: http://www.AIDSinfo.nih.gob (último acceso 10/01/08).
10. Caparelli E., Rakhmanina N., and Mirochnik M. Pharmacoterapy of perinatal HIV. Sem Fetal Neonat M 10 (2005) 161-175
11. Culnane M., Fowler M.G., Lee S., McSherry G., Brady M., O'Donnell K., et al. Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. JAMA 281 (1999) 151-157
12. Sperling R.S., Shapiro D.E., McSherry G.D., Brito P., Cunningham B.E., Culnane M., et al. Safety of the maternal-infant zidovudine regimen utilized in the Pediatric AIDS Clinical Trial Group 076 Study. AIDS 12 (1998) 1805-1813
13. Bellón Cano J., Sánchez-Ramón S., Ciria L., León J.A., Gurbindo D., Fortuny C., et al. The effects on infants of potent antiretroviral therapy during pregnancy: A report from Spain. Med Sci Monit 10 (2004) 179-184
14. European Collaborative Study. Exposure to antiretroviral therapy in utero or early life: The health of uninfected children born to HIV-infected women. J Acquir Immune Defic Syndr 32 (2003) 380-387
15. Mofenson L., and Munderi P. Safety of antiretroviral prophylaxis of perinatal transmission for HIV-infected pregnant women and their infants. J Acquir Immune Defic Syndr 30 (2002) 200-215
16. Sinha G., Choi T.J., Nayak U., Gupta A., Nair S., Gupte N., et al. Clinically significant anemia in HIV-infected pregnant women in India is not a major barrier to zidovudine use for prevention of maternal-to-child transmission. J Acquir Immune Defic Syndr 45 (2007) 200-207
17. Thorne C., and Newell M.L. Safety of agents used to prevent mother- to-child transmission of HIV: Is there any cause for concern?. Drug Safety 30 (2007) 203-213
18. Paul M.E., Chantry C.J., Read J.S., Frederick M.M., Lu M., Pitt J., et al. Morbidity and mortality during the first two years of life among uninfected children born to human immunodeficiency virus type 1-infected women. Pediatr Infect Dis J 24 (2005) 46-56
19. Dainiak N., Worthington M., Riordan M.A., Kreczko S., and Goldman L. 3′Azido-3′deoxythymidine (AZT) inhibits proliferation in vitro of human haematopoietic progenitor cells. Br J Haematol 69 (1988) 299-304
20. Olivero O.A., Shearer G.M., Chougnet C.A., Kovacs A., Landay L., Baker R., et al. Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero. AIDS 13 (1999) 919-925
21. Kowalska A., Niemiec T., El Midaoui A., and Burkacka E. Effect of antiretroviral therapy on pregnancy outcome in HIV-1 positive women. Med Wieku Rozwoj 7 (2003) 459-468
22. Tuomala R., Shapiro D.E., Mofenson L.M., and Bryson Y. Antiretroviral therapy during pregnancy and the risk of an adverse outcome. N Engl J Med 246 (2002) 1863-1870
23. Solis Villamarzo I., Muñoz-Gálligo E., Ramos Amador J.T., González-Tomé M.I., Rojano Luque X., and Almeda Ortega J. Características maternas en una cohorte de gestantes con infección por el virus de la inmunodeficiencia humana-1. Med Clin (Barc) 127 (2006) 121-125
24. National Institute for Allergy and Infectious Disease (NIAID), Division of AIDS. Table for grading the severity of adult and pediatric adverse events, version 1.0. Disponible en: http://www.rcc.tech-res.com/tox_tables (último acceso 10/1/08).
25. Bunders M.J., Beker V., Scherpbier H.J., Boer K., Godfried M., and Kuijpers T.W. Hematological parameters of HIV-1-uninfected infants born to HIV-1-infected mothers. Acta Pediatr 94 (2005) 1571-1577
26. Feiterna-Sperling C., Weizsaecker K., Bührer C., Casteleyn S., Loui A., Schmitz T., et al. Hematologic effects of maternal antiretroviral therapy and transmission prophylaxis in HIV-1-exposed uninfected newborn infants. J Acquir Immune Defic Syndr 45 (2007) 43-51
27. Mussi-Pinhata M., Rego M.A., Freimanis L., Kakehasi F., Machado D.M., Cardoso E.M., et al. Maternal antiretrovirals and hepatic enzyme, hematologic abnormalities among human immunodeficiency virus type 1-uninfected infants. Pediatr Infect Dis J 26 (2007) 1032-1037
28. Le Chedenac J., Mayaux M.J., Guihenneuc-Jouyaux C., and Blanche S. Perinatal antiretroviral treatment and hematopiesis in HIV-uninfected infants. AIDS 17 (2003) 2053-2061
29. Pacheco S.E., Mcintosh K., Lu M., Mofenson L.M., Diaz C., Foca M., et al. Effect of perinatal antiretroviral drug exposure on hematologic values in HIV-uninfected children. An analysis of the women and infants transmission study. J Infect Dis 194 (2006) 1089-1097
30. Taha T.E., Kumwenda N., Kafulafula G., Kumbenda J., Chitale R., Nkhoma C., et al. Haematological changes in African children who received short-term prophylaxis with nevirapine and zidovudine at birth. Ann Tropic Pediatr 24 (2004) 301-309
31. Taha T.E., Kumwenda N., Gibbons A., Hoover D., Lema V., Fiscus S., et al. Effect of HIV-1 antiretroviral prophylaxis on hepatic and hematological parameters of African infants. AIDS 16 (2002) 851-858
32. European Collaborative Study Levels and Pattern of neutrophil cell counts over the first 8 years of life in children of HIV-1-infected mothers. AIDS 18 (2004) 2009-2017
33. Reed W.N., and Diehl L.F. Leukopenia, neutropenia and reduced hemoglobin levels in healthy american blacks. Arch Intern Med 151 (1991) 501-505