Gene expression profile of dorsal root ganglion in a lumbar radiculopathy model

Spine

Volumn 33, Issue 23, 2008, Pages 2483-2488

  Takeuchi, Hirohito ^a   Kawaguchi, Satoshi ^a   Mizuno, Satoshi ^a   Kirita, Takashi ^a   Takebayashi, Tsuneo ^a   Shimozawa, Kumiko ^b   Torigoe, Toshihiko ^a   Sato, Noriyuki ^a   Yamashita, Toshihiko ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

cDNA microarray; Dorsal root ganglion; Lumbar radiculopathy; Nerve root ligation; Sprague Dawley rats

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; GENE CONTROL; GENE EXPRESSION; LUMBAR RADICULOPATHY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RADICULOPATHY; RAT; SPINAL GANGLION; ANIMAL; DISEASE MODEL; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; INJURY; LUMBAR VERTEBRA; MALE; METABOLISM; METHODOLOGY; PAIN; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL ROOT; SPRAGUE DAWLEY RAT; TIME; UPREGULATION;

CARBOCYANINE; CYANINE DYE 3; CYANINE DYE 5; FLUORESCENT DYE; MESSENGER RNA;

ANIMALS; CARBOCYANINES; DISEASE MODELS, ANIMAL; FLUORESCENT DYES; GANGLIA, SPINAL; GENE EXPRESSION; GENE EXPRESSION PROFILING; LUMBAR VERTEBRAE; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PAIN; RADICULOPATHY; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL NERVE ROOTS; TIME FACTORS; UP-REGULATION;

EID: 59649119770     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e318184acc3     Document Type: Article

References (26)

1. Hasue M. Pain and the nerve root: an interdisciplinary approach. Spine 1993;18:2053-305.
2. Winkelstein BA, DeLeo JA. Mechanical thresholds for initiation and persistence of pain following nerve root injury: mechanical and chemical contributions at injury. J Biomech Eng 2004;126:258-63.
3. Song XJ, Vizcarra C, Xu DS, et al. Hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons. J Neurophysiol 2003;89:2185-93.
4. Lacroix-Fralish ML, Tawfik VL, Tanga FY, et al. Differential spinal cord gene expression in rodent models of radicular and neuropathic pain. Anesthesiology 2006;104:1283-92.
5. Reilly SC, Cossins AR, Quinn JP, et al. Discovering genes: the use of microarrays and laser capture microdissection in pain research. Brain Res Brain Res Rev 2004;46:225-33.
6. Zhang X, Xiao HS. Gene array analysis to determine the components of neuropathic pain signaling. Curr Opin Mol Ther 2005;7:532-7.
7. Costigan M, Befort K, KarchewskiL, etal. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci 2002;3:16.
8. Xiao HS, Huang QH, Zhang FX, et al. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci USA 2002;99:8360-5.
9. Valder CR, Liu JJ, Song YH, et al. Coupling gene chip analyses and rat genetic variances in identifying potential target genes that may contribute to neuropathic allodynia development. J Neurochem 2003;87:560-73.
10. Rodriguez Parkitna J, Korostynski M, Kaminska-Chowaniec D, et al. Comparison of gene expression profiles in neuropathic and inflammatory pain. J Physiol Pharmacol 2006;57:401-14.
11. Ko J, NaDS, Lee YH, et al. cDNA microarray analysis ofthe differential gene expression in the neuropathic pain and electroacupuncture treatment models. J Biochem Mol Biol 2002;35:420-7.
12. Sun H, Xu J, Della Penna KB, et al. Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry. BMC Neurosci 2002;3:11.
13. Yang L, Zhang FX, Huang F, et al. Peripheral nerve injury induces transsynaptic modification of channels, receptors and signal pathways in rat dorsal spinal cord. Eur J Neurosci 2004;19:871-83.
14. LaCroix-Fralish ML, Tawfik VL, Spratt KF, et al. Sex differences in lumbar spinal cord gene expression following experimental lumbar radiculopathy. J Mol Neurosci 2006;30:283-95.
15. Kirita T, Takebayashi T, Mizuno S, et al. Electrophysiologic changes in dorsal root ganglion neurons and behavioral changes in a lumbar radiculopathy model. Spine 2007;32:E65-72.
16. Hashizume H, DeLeo JA, Colburn RW, et al. Spinal glial activation and cytokine expression after lumbar root injury in the rat. Spine 2000;25: 1206-17.
17. Abe M, Kurihara T, Han W, et al. Changes in expression of voltagedependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain. Spine 2002;27:1517-24; discussion 25.
18. LeeY, RodriguezC, Dionne RA. The roleofCOX-2 in acute pain and the use of selective COX-2 inhibitors for acute pain relief. Curr Pharm Des 2005; 11:1737-55.
19. Bingham S, Beswick PJ, Blum DE, et al. The role of the cylooxygenase pathway in nociception and pain. Semin Cell Dev Biol 2006;17:544-54.
20. Deleo TA, Hashizume H, Rutkowski MD, et al. Cyclooxygenase-2 inhibitor SC-236 attenuates mechanical allodynia following nerve root injury in rats. J Orthop Res 2000;18:977-82.
21. Kawakami M, Matsumoto T, Hashizume H, et al. Epidural injection of cyclooxygenase-2 inhibitor attenuates pain-related behavior following application of nucleus pulposus to the nerve root in the rat. J Orthop Res 2002;20:376-81.
22. Andre S, Boukhaddaoui H, Campo B, et al. Axotomy-induced expression of calcium-activated chloride current in subpopulations of mouse dorsal root ganglion neurons. J Neurophysiol 2003;90:3764-73.
23. Li C, Hossieny P, Wu BJ, et al. Pharmacologic induction of heme oxygenase-1. Antioxid Redox Signal 2007;9:2227-39.
24. Hirata K,He JW, Kuraoka A, et al. Heme oxygenase1 (HSP-32) isinduced in myelin-phagocytosing Schwann cells of injured sciatic nerves in the rat. Eur J Neurosci 2000;12:4147-52.
25. Barclay J, Clark AK, Ganju P, et al. Role of the cysteine protease cathepsin S in neuropathic hyperalgesia. Pain 2007;130:225-34.
26. Clark AK, Yip PK, Grist J, et al. Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain. Proc Natl Acad Sci USA 2007;104: 10655-60.