Construction and characterization of a single-cycle chimeric flavivirus vaccine candidate that protects mice against lethal challenge with dengue virus type 2

Journal of Virology

Volumn 83, Issue 4, 2009, Pages 1870-1880

  Suzuki, Ryosuke ^a,b   Winkelmann, Evandro R ^a   Mason, Peter W ^a,c  

^a University of Texas Medical Branch School of Medicine   (United States)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC ANTIBODY; DENGUE VACCINE; FLAVIVIRUS VACCINE; GAMMA INTERFERON; INTERFERON; NEUTRALIZING ANTIBODY; REPLIVAX; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANIMAL CELL; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CELL; CONTROLLED STUDY; DENGUE; DENGUE VIRUS; DENGUE VIRUS 2; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; FLAVIVIRUS; GENE; GENE EXPRESSION; GENE MUTATION; GROWTH; HOST; IMMUNITY; INOCULATION; LETHAL DOSE; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; SHAM PROCEDURE; VACCINATION; VIROGENESIS; VIRUS AG129; VIRUS CAPSID; VIRUS CHARACTERIZATION; VIRUS STRAIN; WEST NILE FLAVIVIRUS;

ANIMALS; ANTIBODIES, VIRAL; CELL LINE; CRICETINAE; DENGUE; DENGUE VACCINES; DENGUE VIRUS; FLAVIVIRUS; IMMUNOCOMPROMISED HOST; MICE; NEUTRALIZATION TESTS; SURVIVAL ANALYSIS; VACCINES, SYNTHETIC; WEST NILE VIRUS;

ANIMALIA; DENGUE VIRUS; DENGUE VIRUS TYPE 2; FLAVIVIRUS; MIRIDAE; MUS; WEST NILE VIRUS;

EID: 59649119513     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01891-08     Document Type: Article

References (55)

1. Amberg, S. M., and C. M. Rice. 1999. Mutagenesis of the NS2B-NS3-mediated cleavage site in the flavivirus capsid protein demonstrates a requirement for coordinated processing. J. Virol. 73:8083-8094.
2. Blaney, J. E., Jr., J. M. Matro, B. R. Murphy, and S. S. Whitehead. 2005. Recombinant, live-attenuated tetravalent dengue virus vaccine formulations induce a balanced, broad, and protective neutralizing antibody response against each of the four serotypes in rhesus monkeys. J. Virol. 79:5516-5528.
3. + T cells responding to lethal West Nile virus infection. Eur. J. Immunol. 37:1855-1863.
4. Burke, D. S., and T. P. Monath. 2001. Flaviviruses, p. 1043-1125. In D. M. Knipe, P. M. Howley, D. G. Griffin, R. A. Lamb, M. A. Martin, and B. Roizman (ed.), Fields Virology, 4th ed., vol. 1. Lippincott Williams & Wilkins, Philadelphia, PA.
5. Byrnes, A. P., and D. E. Griffin. 1998. Binding of Sindbis virus to cell surface heparan sulfate. J. Virol. 72:7349-7356.
6. Calvert, A. E., C. Y. Huang, R. M. Kinney, and J. T. Roehrig. 2006. Non-structural proteins of dengue 2 virus offer limited protection to interferon-deficient mice after dengue 2 virus challenge. J. Gen. Virol. 87:339-346.
7. Centers for Disease Control and Prevention. 2008. Prevention of specific infectious diseases: Japanese encephalitis. CDC health information for travelers, 2008. Centers for Disease Control and Prevention, Atlanta, GA.
8. Fayzulin, R., F. Scholle, O. Petrakova, I. Frolov, and P. W. Mason. 2006. Evaluation of replicative capacity and genetic stability of West Nile virus replicons using highly efficient packaging cell lines. Virology 351:196-209.
9. Fonseca, B. A. L. 1994. Vaccinia-vectored dengue vaccine candidates elicit neutralizing antibodies in mice. Doctoral thesis. Yale, New Haven, CT.
10. Galler, R., R. S. Marchevsky, E. Caride, L. F. Almeida, A. M. Yamamura, A. V. Jabor, M. C. Motta, M. C. Bonaldo, E. S. Coutinho, and M. S. Freire. 2005. Attenuation and immunogenicity of recombinant yellow fever 17D-dengue type 2 virus for rhesus monkeys. Braz. J. Med. Biol. Res. 38:1835-1846.
11. Gualano, R. C., M. J. Pryor, M. R. Cauchi, P. J. Wright, and A. D. Davidson. 1998. Identification of a major determinant of mouse neurovirulence of dengue virus type 2 using stably cloned genomic-length cDNA. J. Gen. Virol. 79:437-446.
12. Gubler, D. J., and M. Meltzer. 1999. Impact of dengue/dengue hemorrhagic fever on the developing world. Adv. Virus Res. 53:35-70.
13. Hahn, C. S., Y. S. Hahn, C. M. Rice, E. Lee, L. Dalgarno, E. G. Strauss, and J. H. Strauss. 1987. Conserved elements in the 3′ untranslated region of flavivirus RNAs and potential cyclization sequences. J. Mol. Biol. 198:33-41.
14. Halstead, S. B., and J. Deen. 2002. The future of dengue vaccines. Lancet 360:1243-1245.
15. Hayes, E. B. 2007. Acute viscerotropic disease following vaccination against yellow fever. Trans. R. Soc. Trop. Med. Hyg. 101:967-971.
16. Higuchi, R., B. Krummel, and R. K. Saiki. 1988. A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions. Nucleic Acids Res. 16:7351-7367.
17. Huang, C. Y., S. Butrapet, K. R. Tsuchiya, N. Bhamarapravati, D. J. Gubler, and R. M. Kinney. 2003. Dengue 2 PDK-53 virus as a chimeric carrier for tetravalent dengue vaccine development. J. Virol. 77:11436-11447.
18. Ishikawa, T., D. G. Widman, N. Bourne, E. Konishi, and P. W. Mason. 2008. Construction and evaluation of a chimeric pseudoinfectious virus vaccine to prevent Japanese encephalitis. Vaccine 26:2772-2781.
19. Johnson, A. J., and J. T. Roehrig. 1999. New mouse model for dengue virus vaccine testing. J. Virol. 73:783-786.
20. Khromykh, A. A., and E. G. Westaway. 1994. Completion of Kunjin virus RNA sequence and recovery of an infectious RNA transcribed from stably cloned full-length cDNA. J. Virol. 68:4580-4588.
21. Khromykh, A. A., and E. G. Westaway. 1997. Subgenomic replicons of the flavivirus Kunjin: construction and applications. J. Virol. 71:1497-1505.
22. Klimstra, W. B., K. D. Ryman, and R. E. Johnston. 1998. Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor. J. Virol. 72:7357-7366.
23. Kofler, R. M., J. H. Aberle, S. W. Aberle, S. L. Allison, F. X. Heinz, and C. W. Mandl. 2004. Mimicking live flavivirus immunization with a noninfectious RNA vaccine. Proc. Natl. Acad. Sci. USA 101:1951-1956.
24. Kuhn, R. J., W. Zhang, M. G. Rossmann, S. V. Pletnev, J. Corver, E. Lenches, C. T. Jones, S. Mukhopadhyay, P. R. Chipman, E. G. Strauss, T. S. Baker, and J. H. Strauss. 2002. Structure of dengue virus: Implications for flavivirus organization, maturation, and fusion. Cell 108:717-725.
25. Kummerer, B. M., and C. M. Rice. 2002. Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles. J. Virol. 76:4773-4784.
26. Kurane, I., and F. A. Ennis. 1997. Immunopathogenesis of dengue virus infections, p. 273-290. In D. J. Gubler and G. Kuno (ed.), Dengue and dengue hemorrhagic fever. CABI Publishing, Oxon, United Kingdom.
27. Kyle, J. L., S. J. Balsitis, L. Zhang, P. R. Beatty, and E. Harris. 2008. Antibodies play a greater role than immune cells in heterologous protection against secondary dengue virus infection in a mouse model. Virology 380:296-303.
28. Kyle, J. L., P. R. Beatty, and E. Harris. 2007. Dengue virus infects macrophages and dendritic cells in a mouse model of infection. J. Infect. Dis. 195:1808-1817.
29. Lee, E., R. A. Hall, and M. Lobigs. 2004. Common E protein determinants for attenuation of glycosaminoglycan-binding variants of Japanese encephalitis and West Nile viruses. J. Virol. 78:8271-8280.
30. Lee, E., C. E. Stocks, S. M. Amberg, C. M. Rice, and M. Lobigs. 2000. Mutagenesis of the signal sequence of yellow fever virus prM protein: enhancement of signalase cleavage in vitro is lethal for virus production. J. Virol. 74:24-32.
31. Lee, E., P. J. Wright, A. Davidson, and M. Lobigs. 2006. Virulence attenuation of Dengue virus due to augmented glycosaminoglycan-binding affinity and restriction in extraneural dissemination. J. Gen. Virol. 87:2791-2801.
32. Leung, J. Y., G. P. Pijlman, N. Kondratieva, J. Hyde, J. M. Mackenzie, and A. A. Khromykh. 2008. Role of nonstructural protein NS2A in flavivirus assembly. J. Virol. 82:4731-4741.
33. Lindenbach, B. D., and C. M. Rice. 2001. Flaviviridae: the viruses and their replication, p. 991-1041. In D. M. Knipe, P. M. Howley, D. G. Griffin, R. A. Lamb, M. A. Martin, and B. Roizman (ed.), Fields virology, 4th ed., vol. 1. Lippincott Williams & Wilkins, Philadelphia, PA.
34. Lobigs, M., and E. Lee. 2004. Inefficient signalase cleavage promotes efficient nucleocapsid incorporation into budding flavivirus membranes. J. Virol. 78:178-186.
35. Mandl, C. W., S. L. Allison, H. Holzmann, T. Meixner, and F. X. Heinz. 2000. Attenuation of tick-borne encephalitis virus by structure-based site-specific mutagenesis of a putative flavivirus receptor binding site. J. Virol. 74:9601-9609.
36. Mason, P. W., A. V. Shustov, and I. Frolov. 2006. Production and characterization of vaccines based on flaviviruses defective in replication. Virology 351:432-443.
37. Mori, Y., T. Okabayashi, T. Yamashita, Z. Zhao, T. Wakita, K. Yasui, F. Hasebe, M. Tadano, E. Konishi, K. Moriishi, and Y. Matsuura. 2005. Nuclear localization of Japanese encephalitis virus core protein enhances viral replication. J. Virol. 79:3448-3458.
38. Nakai, K., T. Okamoto, T. Kimura-Someya, K. Ishii, C. K. Lim, H. Tani, E. Matsuo, T. Abe, Y. Mori, T. Suzuki, T. Miyamura, J. H. Nunberg, K. Moriishi, and Y. Matsuura. 2006. Oligomerization of hepatitis C virus core protein is crucial for interaction with the cytoplasmic domain of E1 envelope protein. J. Virol. 80:11265-11273.
39. Patkar, C. G., and R. J. Kuhn. 2008. Yellow fever virus NS3 plays an essential role in virus assembly independent of its known enzymatic functions. J. Virol. 82:3342-3352.
40. Purtha, W. E., N. Myers, V. Mitaksov, E. Sitati, J. Connolly, D. H. Fremont, T. Hansen, and M. S. Diamond. 2007. Antigen-specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis. Eur. J. Immunol. 37:1845-1854.
41. Rossi, S. L., Q. Zhao, V. K. O'Donnell, and P. W. Mason. 2005. Adaptation of West Nile virus replicons to cells in culture and use of replicon-bearing cells to probe antiviral action. Virology 331:457-470.
42. Sa-Carvalho, D., E. Rieder, B. Baxt, R. Rodarte, A. Tanuri, and P. W. Mason. 1997. Tissue culture adaptation of foot-and-mouth disease virus selects viruses that bind to heparin and are attenuated in cattle. J. Virol. 71:5115-5123.
43. Shresta, S., J. L. Kyle, H. M. Snider, M. Basavapatna, P. R. Beatty, and E. Harris. 2004. Interferon-dependent immunity is essential for resistance to primary dengue virus infection in mice, whereas T- and B-cell-dependent immunity are less critical. J. Virol. 78:2701-2710.
44. Shresta, S., K. L. Sharar, D. M. Prigozhin, P. R. Beatty, and E. Harris. 2006. Murine model for dengue virus-induced lethal disease with increased vascular permeability. J. Virol. 80:10208-10217.
45. + T cells in control of West Nile virus infection. J. Virol. 78:8312-8321.
46. + T cells require perforin to clear West Nile virus from infected neurons. J. Virol. 80:119-129.
47. Shustov, A. V., P. W. Mason, and I. Frolov. 2007. Production of pseudoinfectious yellow fever virus with two-component genome. J. Virol. 81:11737-11748.
48. Simmons, M., K. R. Porter, C. G. Hayes, D. W. Vaughn, and R. Putnak. 2006. Characterization of antibody responses to combinations of a dengue virus type 2 DNA vaccine and two dengue virus type 2 protein vaccines in rhesus macaques. J. Virol. 80:9577-9585.
49. Suzuki, R., R. Fayzulin, I. Frolov, and P. W. Mason. 2008. Identification of mutated cyclization sequences that permit efficient replication of West Nile virus genomes: use in safer propagation of a novel vaccine candidate. J. Virol. 82:6942-6951.
50. + T cells mediate recovery and immunopathology in West Nile virus encephalitis. J. Virol. 77:13323-13334.
51. Whitehead, S. S., J. E. Blaney, A. P. Durbin, and B. R. Murphy. 2007. Prospects for a dengue virus vaccine. Nat. Rev. Microbiol. 5:518-528.
52. Widman, D. G., T. Ishikawa, R. Fayzulin, N. Bourne, and P. W. Mason. 2008. Construction and characterization of a second-generation pseudoinfectious West Nile virus vaccine propagated using a new cultivation system. Vaccine 26:2762-2771.
53. Yamshchikov, V. F., and R. W. Compans. 1993. Regulation of the late events in flavivirus protein processing and maturation. Virology 192:38-51.
54. Zhang, W., P. R. Chipman, J. Corver, P. R. Johnson, Y. Zhang, S. Mukhopadhyay, T. S. Baker, J. H. Strauss, M. G. Rossmann, and R. J. Kuhn. 2003. Visualization of membrane protein domains by cryo-electron microscopy of dengue virus. Nat. Struct. Biol. 10:907-912.
55. Zhang, Y., J. Corver, P. R. Chipman, W. Zhang, S. V. Pletnev, D. Sedlak, T. S. Baker, J. H. Strauss, R. J. Kuhn, and M. G. Rossmann. 2003. Structures of immature flavivirus particles. EMBO J. 22:2604-2613.