Changes in tumor vascularity depicted by contrast-enhanced ultrasonography as a predictor of chemotherapeutic effect in patients with unresectable pancreatic cancer

Pancreas

Volumn 38, Issue 1, 2009, Pages 30-35

  Tawada, Katsunobu ^a   Yamaguchi, Taketo ^a,b   Kobayashi, Akitoshi ^c   Ishihara, Takeshi ^a   Sudo, Kentaro ^b   Nakamura, Kazuyoshi ^b   Hara, Tarou ^b   Denda, Tadamichi ^b   Matsuyama, Masato ^a   Yokosuka, Osamu ^a  

^a CHIBA UNIVERSITY   (Japan)

^b CHIBA CANCER CENTER   (Japan)

^c Funabashi Municipal Hospital   (Japan)

Author keywords

Angiogenesis; Contrast enhanced ultrasonography; Pancreatic adenocarcinoma; Tumor vascularity

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; GEMCITABINE; SHU 508; ANTINEOPLASTIC AGENT; CONTRAST MEDIUM; DIAGNOSTIC AGENT; POLYSACCHARIDE;

ADULT; ADVANCED CANCER; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER PATIENT; CLINICAL ARTICLE; CONTRAST ENHANCEMENT; ECHOGRAPHY; FEMALE; HISTOPATHOLOGY; HUMAN; INOPERABLE CANCER; LIVER METASTASIS; LUNG METASTASIS; MALE; MULTIPLE CYCLE TREATMENT; OVERALL SURVIVAL; PANCREAS CARCINOMA; PERITONEUM METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROGRESSION FREE SURVIVAL; SYSTEMIC THERAPY; TREATMENT RESPONSE; TUMOR VASCULARIZATION; ADENOCARCINOMA; DISEASE FREE SURVIVAL; DOPPLER FLOWMETRY; KAPLAN MEIER METHOD; METASTASIS; MIDDLE AGED; MORTALITY; NEOVASCULARIZATION (PATHOLOGY); PANCREAS TUMOR; PREDICTION AND FORECASTING; RADIOGRAPHY; SPIRAL COMPUTER ASSISTED TOMOGRAPHY; TIME; TREATMENT OUTCOME; VASCULARIZATION;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; CONTRAST MEDIA; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PANCREATIC NEOPLASMS; POLYSACCHARIDES; PREDICTIVE VALUE OF TESTS; TIME FACTORS; TOMOGRAPHY, SPIRAL COMPUTED; TREATMENT OUTCOME; ULTRASONOGRAPHY, DOPPLER;

EID: 59649116766     PISSN: 08853177     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPA.0b013e318183ff73     Document Type: Article

References (24)

1. Seo Y, Baba H, Fukuda T, et al. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer. 2000;88: 2239-2245.
2. Wang ZQ, Li JS, Lu GM, et al. Correlation of CT enhancement, tumor angiogenesis and pathologic grading of pancreatic carcinoma. World J Gastroenterol. 2003;9:2100-2104.
3. Takagi K, Takada T, Amano H. A high peripheral microvessel density count correlates with a poor prognosis in pancreatic cancer. J Gastroenterol. 2005;40:402-408.
4. Couvelard A, O'Toole D, Leek R, et al. Expression of hypoxia-inducible factors is correlated with the presence of a fibrotic focus and angiogenesis in pancreatic ductal adenocarcinomas. Histopathology. 2005;46:668-676.
5. Karayiannakis AJ, Bolanaki H, Syrigos KN, et al. Serum vascular endothelial growth factor levels in pancreatic cancer patients correlate with advanced and metastatic disease and poor prognosis. Cancer Lett. 2003;194:119-124.
6. Ellis LM, Takahashi Y, Fenoglio CJ, et al. Vessel counts and vascular endothelial growth factor expression in pancreatic adenocarcinoma. Eur J Cancer. 1998;34:337-340.
7. Ohshima T, Yamaguchi T, Ishihara T, et al. Evaluation of blood flow in pancreatic ductal carcinoma using contrast-enhanced, wide-band Doppler ultrasonography: correlation with tumor characteristics and vascular endothelial growth factor. Pancreas. 2004;28:335-343.
8. Zhongqiu W, Guangming L, Jieshou L, et al. The comparative study of tumor angiogenesis and CT enhancement in pancreatic carcinoma. Eur J Radiol. 2004;49:274-280.
9. D'Onofrio M, Malago R, Zamboni G, et al. Contrast-enhanced ultrasonography better identifies pancreatic tumor vascularization than helical CT. Pancreatology. 2005;5:398-402.
10. Masaki T, Ohkawa S, Amano A, et al. Noninvasive assessment of tumor vascularity by contrast-enhanced ultrasonography and the prognosis of patients with nonresectable pancreatic carcinoma. Cancer. 2005;5:1026-1035.
11. Therasse P, Arbuck SG, Eisenhauer EA, et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000;92:205-216.
12. Burris HA 3rd, Moore MJ, Andersen J, et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial. J Clin Oncol. 1997;15:2403-2413.
13. Lassau N, Koscielny S, Opolon P, et al. Evaluation of contrast-enhanced color Doppler ultrasound for the quantification of angiogenesis in vivo. Invest Radiol. 2001;36:50-55.
14. Takeda K, Goto H, Hirooka Y, et al. Contrast-enhanced transabdominal ultrasonography in the diagnosis of pancreatic mass lesions. Acta Radiol. 2003;44:103-106.
15. Kitano M, Kudo M, Maekawa K, et al. Dynamic imaging of pancreatic diseases by contrast enhanced coded phase inversion harmonic ultrasonography. Gut. 2004;53:854-859.
16. Nagase M, Furuse J, Ishii H, et al. Evaluation of contrast enhancement patterns in pancreatic tumors by coded harmonic sonographic imaging with a microbubble contrast agent. J Ultrasound Med. 2003;22: 789-795.
17. Chen CN, Cheng YM, Lin MT, et al. Association of color Doppler vascularity index and microvessel density with survival in patients with gastric cancer. Ann Surg. 2002;235:512-518.
18. Wilson NM, Masoud AM, Barsoum HB, et al. Correlation of power Doppler with microvessel density in assessing prostate needle biopsy. Clin Radiol. 2004;59:946-950.
19. Cheng WF, Lee CN, Chu JS, et al. Vascularity index as a novel parameter for the in vivo assessment of angiogenesis in patients with cervical carcinoma. Cancer. 1999;85:651-657.
20. Yang WT, Tse GM, Lam PK, et al. Correlation between color power Doppler sonographic measurement of breast tumor vasculature and immunohistochemical analysis of microvessel density for the quantitation of angiogenesis. J Ultrasound Med. 2002;21:1227-1235.
21. Ogura O, Takebayashi Y, Sameshima T, et al. Preoperative assessment of vascularity by color Doppler ultrasonography in human rectal carcinoma. Dis Colon Rectum. 2001;44:538-546.
22. Zhang X, Galardi E, Duquette M, et al. Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. Clin Cancer Res. 2005;11:5622-5630.
23. Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 2005;307:58-62.
24. Donnelly EF, Geng L, Wojcicki WE, et al. Quantified power Doppler US of tumor blood flow correlates with microscopic quantification of tumor blood vessels. Radiology. 2001;219:166-170.