Pilot study on trihexyphenidyl in the treatment of dystonia in children with cerebral palsy

Journal of Child Neurology

Volumn 24, Issue 2, 2009, Pages 176-182

  Rice, James ^a   Waugh Mary Clare, M C ^b  

^a WOMEN S AND CHILDREN S HOSPITAL   (Australia)

^b CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

Author keywords

Cerebral palsy; Dystonia; Placebo; Randomized; Trihexyphenidyl

Indexed keywords

PLACEBO; TRIHEXYPHENIDYL;

ADOLESCENT; AGITATION; ARTICLE; BEHAVIOR CHANGE; BLURRED VISION; CEREBRAL PALSY; CHILD; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONFUSION; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DISTRESS SYNDROME; DOUBLE BLIND PROCEDURE; DRUG DOSE REDUCTION; DRUG WITHDRAWAL; DYSTONIA; FEMALE; GOAL ATTAINMENT; HALLUCINATION; HUMAN; MALE; MOTOR DYSFUNCTION; PEDIATRIC HOSPITAL; PHYSICAL PERFORMANCE; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SIDE EFFECT; SLEEP DISORDER; TACHYCARDIA; TREATMENT OUTCOME; URINE INCONTINENCE; VOMITING; XEROSTOMIA;

ADOLESCENT; CEREBRAL PALSY; CHILD; CHILD, PRESCHOOL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DYSTONIA; FEMALE; HUMANS; MALE; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TESTS; PILOT PROJECTS; QUESTIONNAIRES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; TRIHEXYPHENIDYL;

EID: 59649109770     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/0883073808322668     Document Type: Article

References (19)

1. Sanger TD, Delgado MR, Gaebler-Spira D., Hallett M., Mink JW, and the Task Force on Childhood Motor Disorders. Classification and definition of disorders causing hypertonia in childhood. Pediatrics. 2003;111:e89-e97.
2. Bax M., Goldstein M., Rosenbaum P., et al. and the Executive Committee for the Definition of Cerebral Palsy. Proposed definition and classification of cerebral palsy. Dev Med Child Neurol. 2005;47:571-576.
3. Sanger TD Paediatric movement disorders. Curr Opin Neurol. 2003;16:529-535.
4. Howard J., Soo B., Graham HK, et al. Cerebral palsy in Victoria: Motor types, topography and gross motor function. J Paediatr Child Health. 2005;41:479-483.
5. Du Plessis A. Mechanisms and manifestations of prenatal and perinatal brain injury. In: Gage J, ed. The Treatment of Gait Problems in Cerebral Palsy. London: Mac Keith Press; 2004:15-31.
6. Marsden CD, Marion MH, Quinn N. The treatment of severe dystonia in children and adults. J Neurol Neurosurg Psychiatr. 1984;47:1166-1173.
7. Sanger TD, Bastian A., Brunstrom J., et al. and the Child Motor Study Group. Prospective open-label trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy. J Child Neurol. 2007;22:530-537.
8. Hoon AH Jr, Freese PO, Reinhardt EM, et al. Age-dependent effects of benzhexol in extrapyramidal cerebral palsy. Pediatr Neurol. 2001;25:55-58.
9. Fahn S. High dosage anticholinergic therapy in dystonia. Neurology. 1983;33:1255-1261.
10. Vogels OJ, Maassen B., Rotteveel JJ, Merx JL Focal dystonia and speech impairment responding to anticholinergic therapy. Pediatr Neurol. 1994;11:346-348.
11. Pidcock FS, Hoon AH Jr, Johnston MV Benzhexol in posthemorrhagic dystonia: Motor and language effects. Pediatr Neurol. 1999;20:219-222.
12. Barry MJ, VanSwearingen JM, Albright AL Reliability and responsiveness of the Barry-Albright dystonia scale. Dev Med Child Neurol. 1999;41:404-411.
13. DeMatteo C., Law M., Russell D., Pollock N., Rosenbaum P., Walter S. Quality of Upper Extremity Skills Test. Hamilton, Canada: Neurodevelopmental Clinical Research Unit; 1992.
14. DeMatteo C., Law M., Russell D., Pollock N., Rosenbaum P., Walter S. The reliability and validity of the Quality of Upper Extremity Skills Test. Pediatr Phys Occup Ther. 1993;13:1-18.
15. Law M., Baptiste S., McColl M., Opzoomer A., Pollock N., Polatajko H. The Canadian Occupational Performance Measure: An outcome measurement protocol for occupational therapy. Can J Occ Ther. 1990;57:82-87.
16. Palisano RJ Validity of goal attainment scaling in infants with motor delays. Phys Ther. 1993;73:651-748.
17. Maloney FP, Brooks C., Mirret P., Johannes K. Use of goal attainment scale in the treatment and on-going evaluation of neurologically handicapped children. Am J Occ Ther. 1978;32:505-511.
18. Randall M., Carlin JB, Chondros P., Reddihough D. Reliability of the Melbourne assessment of unilateral upper limb function. Dev Med Child Neurol. 2001;43:761-767.
19. Bower E. Goal setting and the measurement of change. In: Scrutton D, Damiano D, Mayston M, eds. Management of the Motor Disorders of Children with Cerebral Palsy. London: Mac Keith Press; 2004:32-51.