Prospective open-label clinical trial of trihexyphenidyl in children with secondary dystonia due to cerebral palsy

Journal of Child Neurology

Volumn 22, Issue 5, 2007, Pages 530-537

  Sanger, Terence D ^a   Bastian, Amy ^b   Brunstrom, Jan ^c   Damiano, Diane ^c   Delgado, Mauricio ^d   Dure, Leon ^e   Gaebler Spira, Deborah ^f   Hoon, Alec ^b   Mink, Jonathan W ^g   Sherman Levine, Sara ^a   Welty, Leah J ^h   Arrick, Sandy ^c   Clegg, Nancy ^d   Lane, Jane ^e   Pendley, Donna ^e   Plumb, Sandy ^g   Simpson, Janet ^f   Stashinko, Elaine ^b   Vierhile, Amy ⁱ   Pesci, Teresa Juodvalkis ^b   Kalb, Darla ^d   Kitsuwa Lowe, Janis ^j   Lang, Catherine ⁱ   Renneker, Kristi ^e   Schuberth, Linda ^b   Silva, Adriana ^f   Weber, Christy ^d   Weber, Julie ^c   Wingert, Jason ^c   Yasakawa, Audrey ^f   Anderson, Julie ^c   Hudson, Brandon ^c   Murphy, Kimberly ^k   Polholsky, Terri ^d   Fisher, Paul ^k   Hahn, Jin ^k   Sita, Pat ^k   more..

^a STANFORD UNIVERSITY   (United States)

^b KENNEDY KRIEGER INSTITUTE   (United States)

^c WASHINGTON UNIVERSITY   (United States)

^d TEXAS SCOTTISH RITE HOSPITAL FOR CHILDREN   (United States)

^e UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^f REHABILITATION INSTITUTE OF CHICAGO   (United States)

^g UNIVERSITY OF ROCHESTER   (United States)

^h NORTHWESTERN UNIVERSITY   (United States)

ⁱ UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^j LUCILE PACKARD CHILDREN S HOSPITAL   (United States)

^k Lucile Packard Children's Hospital ^*

more..

Author keywords

Anticholinergic; Dystonia; Trihexyphenidyl

Indexed keywords

TRIHEXYPHENIDYL;

ADOLESCENT; ARM DISEASE; ARTICLE; BLURRED VISION; CEREBRAL PALSY; CHILD; CHOREA; CLINICAL TRIAL; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG ERUPTION; DRUG MEGADOSE; DRUG MONITORING; DRUG RESPONSE; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; DYSTONIA; EXERCISE TOLERANCE; FATIGUE; FEMALE; HUMAN; HYPERACTIVITY; MALE; MOTOR PERFORMANCE; MULTICENTER STUDY; OPEN STUDY; OUTCOME ASSESSMENT; PILOT STUDY; PRIORITY JOURNAL; SIDE EFFECT; TREATMENT DURATION;

ADOLESCENT; CEREBRAL PALSY; CHILD; CHILD, PRESCHOOL; CLINICAL PROTOCOLS; DYSTONIA; FEMALE; HUMANS; MALE; MUSCARINIC ANTAGONISTS; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; TRIHEXYPHENIDYL;

EID: 34250761947     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/0883073807302601     Document Type: Article

References (31)

1. Crothers B., Paine R. The Natural History of Cerebral Palsy. Vol 2. Philadelphia, Pa: J B Lippincott; 1959.
2. Brunstrom JE, Bastian AJ, Wong M., Mink JW Motor benefit from levodopa in spastic quadriplegic cerebral palsy. Ann Neurol. 2000; 47: 662-665.
3. Sanger TD, Delgado MR, Gaebler-Spira D., et al. Classification and definition of disorders causing hypertonia in childhood. Pediatrics. 2003; 111: E89-e97.
4. Gracies JM, Elovic E., McGuire J., Simpson DM Traditional pharmacological treatments for spasticity. Part i: Local treatments. Muscle Nerve Suppl. 1997; 6: S61-S91.
5. Gracies JM, Nance P., Elovic E., et al. Traditional pharmacological treatments for spasticity. Part ii: General and regional treatments. Muscle Nerve Suppl. 1997; 6: S92-S120.
6. Scott BL, Jankovic J. Delayed-onset progressive movement disorders after static brain lesions. Neurology. 1996; 46: 68-74.
7. Volpe JJ Neurology of the Newborn. 4th ed. Philadelphia, Pa: W B Saunders; 2000.
8. Volpe JJ Encephalopathy of prematurity includes neuronal abnormalities. Pediatrics. 2005; 116: 221-225.
9. Fahn S., Bressman SB, Marsden CD Classification of dystonia. Adv Neurol. 1998; 78: 1-10.
10. Balash Y., Giladi N. Efficacy of pharmacological treatment of dystonia: evidence-based review including meta-analysis of the effect of botulinum toxin and other cure options. Eur J Neurol. 2004; 11: 361-370.
11. Fahn S. High dosage anticholinergic therapy in dystonia. Neurology. 1983; 33: 1255-1261.
12. Jabbari B., Scherokman B., Gunderson CH, et al. Treatment of movement disorders with trihexyphenidyl. Mov Disord. 1989; 4: 202-212.
13. Burke RE, Fahn S., Marsden CD, et al. Validity and reliability of a rating scale for the primary torsion dystonias. Neurology. 1985; 35: 73-77.
14. Pranzatelli MR Oral pharmacotherapy for the movement disorders of cerebral palsy. J Child Neurol. 1996; 11 (suppl 1): S13-S22.
15. Hoon AH Jr, Freese PO, Reinhardt EM, et al. Age-dependent effects of trihexyphenidyl in extrapyramidal cerebral palsy. Pediatr Neurol. 2001; 25: 55-58.
16. Galarraga E., Hernandez-Lopez S., Reyes A., et al. Cholinergic modulation of neostriatal output: A functional antagonism between different types of muscarinic receptors. J Neurosci. 1999; 19: 3629-3638.
17. Burke RE, Macaya A., DeVivo D., et al. Neonatal hypoxic-ischemic or excitotoxic striatal injury results in a decreased adult number of substantia nigra neurons. Neuroscience. 1992; 50: 559-569.
18. Kostic V., Przedborski S., Jackson-Lewis V., et al. Effect of unilateral perinatal hypoxic-ischemic brain injury in the rat on striatal muscarinic cholinergic receptors and high-affinity choline uptake sites: a quantitative autoradiographic study. J Neurochem. 1991; 57: 1962-1970.
19. Burke RE, Karanas AL Quantitative morphological analysis of striatal cholinergic neurons in perinatal asphyxia. Ann Neurol. 1990; 27: 81-88.
20. Palisano R., Rosenbaum P., Walter S., et al. Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol. 1997; 39: 214-223.
21. Randall M., Carlin JB, Chondros P., Reddihough D. Reliability of the Melbourne assessment of unilateral upper limb function. Dev Med Child Neurol. 2001; 43: 761-767.
22. Barry MJ, VanSwearingen JM, Albright AL Reliability and responsiveness of the Barry-Albright Dystonia Scale. Dev Med Child Neurol. 1999; 41: 404-411.
23. Bohannon RW, Smith MB Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther. 1987; 67: 206-207.
24. Blackburn M., van Vliet P., Mockett SP Reliability of measurements obtained with the modified Ashworth scale in the lower extremities of people with stroke. Phys Ther. 2002; 82: 25-34.
25. Sloan RL, Sinclair E., Thompson J., et al. Inter-rater reliability of the modified Ashworth scale for spasticity in hemiplegic patients. Int J Rehabil Res. 1992; 15: 158-161.
26. Russell DJ, Avery LM, Rosenbaum PL, et al. Improved scaling of the gross motor function measure for children with cerebral palsy: Evidence of reliability and validity. Phys Ther. 2000; 80: 873-885.
27. Lerman JA, Sullivan E., Barnes DA, Haynes RJ The Pediatric Outcomes Data Collection Instrument (PODCI) and functional assessment of patients with unilateral upper extremity deficiencies. J Pediatr Orthop. 2005; 25: 405-407.
28. Varni JW, Seid M., Kurtin PS PedsQL 4.0: Reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care. 2001; 39: 800-812.
29. Varni JW, Seid M., Knight TS, et al. The PedsQL 4.0 generic core scales: sensitivity, responsiveness, and impact on clinical decision-making. J Behav Med. 2002; 25: 175-193.
30. Marsden CD, Marion MH, Quinn N. The treatment of severe dystonia in children and adults. J Neurol Neurosurg Psychiatry. 1984; 47: 1166-1173.
31. Burke RE, Fahn S., Marsden CD Torsion dystonia: A double-blind, prospective trial of high-dosage trihexyphenidyl. Neurology. 1986; 36: 160-164.