In vitro and in vivo analysis of [64Cu-NO2A-8-Aoc-BBN(7-14)NH2]: a site-directed radiopharmaceutical for positron-emission tomography imaging of T-47D human breast cancer tumors

Nuclear Medicine and Biology

Volumn 36, Issue 2, 2009, Pages 171-181

  Prasanphanich, Adam F ^a,b   Retzloff, Lauren ^a   Lane, Stephanie R ^c   Nanda, Prasant K ^a   Sieckman, Gary L ^b   Rold, Tammy L ^a   Ma, Lixin ^a,b   Figueroa, Said D ^a,b   Sublett, Samantha V ^a   Hoffman, Timothy J ^a,b   Smith, Charles J ^a,b,c  

^a University of Missouri   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

Author keywords

Bombesin; Copper 64; Gastrin releasing peptide; NOTA; Site directed radiopharmaceutical; T 47D

Indexed keywords

(1,4,7 TRIAZACYCLONONANE 1,4 DIACETATE)(8 AMINOOCTANOIC ACID)GLYCYLTRYPTOPHYLALANYVALYLGLYCYLHISTIDINYLLEUCYLMETHIONINAMIDE; 1,4,7 TRIAZACYCLONONANE 1,4,7 TRIACETIC ACID; BOMBESIN; CHELATING AGENT; COPPER 64; GASTRIN RELEASING PEPTIDE RECEPTOR; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER DIAGNOSIS; CHELATION; CHEMICAL MODIFICATION; CONJUGATION; CONTROLLED STUDY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DRUG RETENTION; DRUG UPTAKE; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MICRO-COMPUTED TOMOGRAPHY; MICROMAGNETIC RESONANCE IMAGING; MICROPOSITRON EMISSION TOMOGRAPHY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REACTION OPTIMIZATION; TISSUE SPECIFICITY; TUMOR XENOGRAFT;

ANIMALS; BOMBESIN; BREAST NEOPLASMS; CELL LINE, TUMOR; COPPER RADIOISOTOPES; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MICE; ORGANOMETALLIC COMPOUNDS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RECEPTORS, BOMBESIN; TISSUE DISTRIBUTION;

EID: 59649105956     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2008.11.005     Document Type: Article

References (41)

1. Kung H.C., Hoyert D.L., Hu J., and Murphy S.L. Deaths: final data for 2004. Nat Vital Stat Rep 56 10 (2008)
2. American Cancer Society. Breast cancer facts & figures (2007-2008), American Cancer Society, Inc., Atlanta
3. American Cancer Society. Cancer facts & figures (2008), American Cancer Society, Inc., Atlanta
4. Prasad N.S., and Houserkova D. The roles of various modalities in breast imaging. Biomed Pap Fac Univ Palacky Olomouc Czech Repub 151 (2007) 209-218
5. Pisano E.D., Gatsonis C., Hendrick E., Yaffe M., Baum J.K., Acharyya S., et al. Diagnostic performance of digital versus film mammography for breast-cancer screening. N Engl J Med 353 (2005) 1773-1783
6. Kaida H., Ishibashi M., Fujii T., Kurata S., Ogo E., Tanaka M., et al. Improved detection of breast cancer on FDG-PET cancer screening using breast positioning device. Ann Nucl Med 22 (2008) 95-101
7. Lacroix M., and Leclercq G. Relevance of breast cancer cell lines as models for breast tumors: an update. Breast Can Res Treat 83 (2004) 249-289
8. Engel L.W., and Young N.A. Human breast carcinoma cells in continuous culture: a review. Can Res 38 (1978) 4327-4339
9. Giacchetti S., Gauville C., de Cremoux P., Bertin L., Berthon P., Abita J.P., et al. Characterization, in some human breast cancer cell lines, of gastrin-releasing peptide-like receptors which are absent in normal breast epithelial cells. Int J Can 46 (1990) 293-298
10. 2] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues. Proc Natl Acad Sci U S A 104 (2007) 12462-12467
11. 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems. J Nucl Med 48 (2007) 1327-1337
12. Parry J.J., Andrews R., and Rogers B.E. MicroPET imaging of breast cancer using radiolabeled bombesin analogs targeting the gastrin-releasing peptide receptor. Breast Cancer Res Treat 101 (2007) 175-183
13. 4)-Bombesin(1-14). Bioconj Chem 18 (2007) 724-730
14. Guojun W., Wei G., Kedong O., Yi H., Yanfei X., Qingmei C., et al. A novel vaccine targeting pastrin-releasing peptide: efficient inhibition of breast cancer growth in vivo. Endorc-Rel Can 15 (2008) 149-159
15. Zhou J., Chen J., Mokotoff M., Zhong R., Shultz L.D., and Ball E.D. Bombesin/gastrin-releasing peptide receptor: a potent target for antibody-mediated therapy of small cell lung cancer. Clin Can Res 9 (2003) 4953-4960
16. 2 peptide conjugate, a high affinity-fluorescent probe with high selectivity for the gastrin-releasing peptide receptor. Mol Imaging 6 (2007) 171-180
17. 111In-labeled E. coli heat-stable enterotoxin analogs for specific targeting of human breast cancers. Breast Can Res Treat 98 (2006) 7-15
18. Aliaga A., Rousseau J.A., Ouellette R., Cadorette J., van Lier J.E., Lecomte R., et al. Breast cancer models to study the expression of estrogen receptors with small animal PET imaging. Nuc Med Bio 31 (2004) 761-770
19. Sprague J.E., Peng Y., Fiamengo A.L., Woodin K.S., Southwick E.A., Weisman G.R., et al. Synthesis, characterization and in vivo studies of Cu(II)-64-labeled cross-bridged tetraazamacrocycle-amide complexes as models of peptide conjugate Imaging Agents. J Med Chem 50 (2007) 2527-2535
20. Weiner R.E., and Thakur M.L. Radiolabeled peptides in oncology. Biodrugs 19 (2005) 145-163
21. Nijsen J.F.W., Krijer G.C., and van het Schip A.D. The bright future of radionuclides for cancer therapy. Anti-Can Agents Med Chem 7 (2007) 271-290
22. Blower P.J., Lewis J.S., and Zweit J. Copper radionuclides and radiopharmaceuticals in nuclear medicine. Nucl Med Bio 23 (1996) 957-980
23. Wadas T.J., Wong E.H., Weisman G.R., and Anderson C.J. Copper chelation chemistry and its role in copper radiopharmaceuticals. Cur Pharmaceutical Des 13 (2007) 3-16
24. 64Cu PET imaging agents for personalized medicine and drug development using the hexa-aza cage, SarAr. Org Biomol Chem 4 (2006) 3350-3357
25. 64Cu-labeling, and bioconjugation of a new bis(2-pyridylmethyl) derivative of 1,4,7-triazacyclononane. Bioconj Chem 19 (2008) 719-730
26. Kukis D.L., Li M., and Meares C.F. Selectivity of antibody-chelate conjugates for binding copper in the presence of competing metals. Inorg Chem 32 (1993) 3981-3982
27. 64Cu-SarAr immunoconjugates. Proc Natl Acad Sci U S A 104 (2007) 17489-17493
28. Di Bartolo N.M., Sargeson A.M., Donlevy T.M., and Smith S.V. Synthesis of a new cage ligand, SarAr, and its complexation with selected transition metal ions for potential use in radioimaging. J Chem Soc Dalton Trans (2001) 2303-2309
29. Pippin C.G., Kumar K., Mirzadeh S., and Gansow O.A. Kinetics of the isotopic exchange between copper(II) and copper(II) 1,4,7-triazacyclononane-N,N′,N′ triacetate. J Label Compd Radiopharm 30 (1991) 221
30. Geraldes C.F.G.C., Marques M.P., de Castro B., and Pereira E. Study of copper(II) polyazamacrocyclic complexes by electronic absorption spectrophotometry and EPR spectroscopy. Eur J Inorg Chem (2000) 559-565
31. 2O. Inorg Chem 21 (1982) 4308-4314
32. van der Merwe M.J., Boeyens J.C.A., and Hancock R.D. Crystallographic and thermodynamic study of metal ion size selectivity in the ligand 1,4,7-triazacyclononane-N,N′,N″-triacetate. Inorg Chem 24 (1985) 1208-1213
33. Prasanphanich A.F., Lane S.R., Figueria S.D., Ma L., Rold T.L., Sieckman G.L., et al. The effects of linking substituents on the in vivo behavior of site-directed, peptide-based, diagnostic radiopharmaceuticals. In Vivo 21 (2007) 1-16
34. 99mTc [13Leu] bombesin and a new gamma camera, the probe, are able to guide mammotome breast biopsy. Antican Res 23 (2003) 2139-2142
35. Maina T., Nock B.A., Zhang H., Nikolopoulou A., Waser B., Reubi J.C., et al. Species differences of bombesin analog interactions with GRP-R define the choice of animal models in the development of GRP-R-targeting drugs. J Nucl Med 46 (2005) 823-830
36. Monstein H.J., Grahn N., Truedsson M., and Ohlsson B. Progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA expression in non-tumor tissues of the human gastrointestinal tract. World J Gastroenterol 12 (2006) 2574-2578
37. Sun Y.G., and Chen Z.F. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 488 (2007) 700-703
38. Roesler R., Lessa D., Venturella R., Vianna M.R.M., Luft T., Henriques J.A.P., et al. Bombesin/gastrin-releasing peptide receptors in the basolateral amygdale regulate memory consolidation. Eur J Neurosci 19 (2004) 1041-1045
39. Boswell C.A., Sun X., Niu W., Weisman G.R., Wong E.H., Rheingold A.L., et al. Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes. J Med Chem 47 (2004) 1465-1474
40. Gotthardt M., van Eerd-Vismale J., Oyen W.J.G., de Jong M., Zhang H., Rolleman E., et al. Indication for different mechanisms of kidney uptake of radiolabeled peptides. J Nucl Med 48 (2007) 596-601
41. Rubin P., and Casarett G.W. Clinical radiation pathology as applied to curvature radiotherapy. Cancer 22 (2006) 767-778