ADRA2A polymorphism and smoking in a Turkish population

Toxicology and Industrial Health

Volumn 24, Issue 3, 2008, Pages 171-176

  Karahalil, B ^a   Coskun, E ^a   Emerce, E ^a  

^a GAZI UNIVERSITY   (Turkey)

Author keywords

ADRA2A gene; C1291G genetic polymorphism; ethnic differences; race differences; smoking habit; Turkish population

Indexed keywords

ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; RECEPTOR, ADRENERGIC, ALPHA 2A; RECEPTOR, ADRENERGIC, ALPHA-2A; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; CAUCASIAN; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; POPULATION RESEARCH; RACE DIFFERENCE; RECEPTOR GENE; SMOKING; SMOKING HABIT; TOBACCO DEPENDENCE; TURKEY (REPUBLIC); BLOOD; ETHNOLOGY; GENETICS; MIDDLE AGED; PHYSIOLOGY;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENE FREQUENCY; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, ADRENERGIC, ALPHA-2; SMOKING; TURKEY; YOUNG ADULT;

EID: 59649105052     PISSN: 07482337     EISSN: None     Source Type: Journal    
DOI: 10.1177/0748233708093354     Document Type: Article

References (20)

1. Cami J, Farre M (2003) Drug addiction. N Engl J Med 349: 975–986.
2. Clark DA, Mata I, Kerwin RW, Munro J, Arranz MJ (2007) No association between ADRA2A polymorphisms and schizophrenia. Am J Med Genet B Neuropsychiatr Genet 144: 341–343.
3. Devedjian C, Pujol A, Cayla C, George M, Casellas A, Paris H (2000) Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis. Diabetologia 43: 899–906.
4. Eason MG, Liggett SB (1993) Human alpha 2-adrenergic receptor subtype distribution: widespread and subtype-selective expression of alpha 2C10, alpha 2C4, and alpha 2C2 mRNA in multiple tissues. Mol Pharmacol 44: 70–75.
5. Garenc C, Perusse L, Chagnon YC, Rankinen T, Gagnon J, Borecki IB (2002) The alpha2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study. Mol Med 8: 88–94.
6. Hein L, Altman JD, Kobilka BK (1999) Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. Nature 402: 181–184.
7. Karahalil B, Kocabas NA (2005) hOGG1 Ser326Cys genetic polymorphism in a Turkish population. Arch Toxicol 79: 377–380.
8. Lafontan M, Berlan M (1995) Fat cell alpha 2-adrenoceptors: the regulation of fat cell function and lipolysis. Endocr Rev 16: 716–738.
9. Lima JJ, Feng H, Duckworth L, Wang J, Sylvester JE, Kissoon N (2007) Association analyses of adrenergic receptor polymorphisms with obesity and metabolic alterations. Metab Clin Exp 56: 757–765.
10. Matsunaga T, Yasuda K, Adachi T, Gu N, Yamamura T, Moritani T (2007) Alpha-adrenoceptor gene variant and autonomic nervous system function in a young healthy Japanese population. J Hum Genet 52: 28–37.
11. Ohara K, Nagai M, Tani K, Tsukamoto T, Suzuki Y, Ohara K (1998) Polymorphism in the promoter region of the alpha 2A adrenergic receptor gene and mood disorders. Neuroreport 9: 1291–1294.
12. Park L, Nigg JT, Waldman ID, Nummy KA, Huang-Pollock C, Rappley M (2005) Association and linkage of a-2A adrenergic receptor gene polymorphisms with childhood ADHD. Mol Psychiatry 10: 572–580.
13. Picciotto MR, Corrigall WA (2002) Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics. J Neurosci 22: 3338–3341.
14. Polanczyk G, Zeni C, Genro JP, Guimaraes AP, Roman T, Hutz MH (2007) Association of the adrenergic alpha2A receptor gene with methylphenidate improvement of inattentive symptoms in children and adolescents with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 64: 218–224.
15. Prestes AP, Marques FZC, Hutz MH, Roman T, Bau CHD (2007) Tobacco smoking and the ADRA2A C-1291G polymorphism. J Neural Transm 114: 1503–1506.
16. Roman T, Schmitz M, Polanczyk GV, Eizirik M, Rohde LA, Hutz MH (2003) Is the alpha-2A adrenergic receptor gene (ADRA2A) associated with attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 120: 116–120.
17. Rosmond R, Bouchard C, Bjorntorp P (2002) A C-1291G polymorphism in the alpha2A-adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels. J Intern Med 251: 252–257.
18. Tsai SJ, Wang YC, Hong CJ (2001) Allelic variants of the α1a adrenoceptor and the promoter region of the α2a adrenoceptor and temperament factors. Am J Med Genet 105: 96–98.
19. Wang B, Wang Y, Rulun Z, Li J, Qian Q, Yang L (2006) Possible association of the alpha-2A adrenergic receptor gene (ADRA2A) with symptoms of attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 141B: 130–134.
20. Wang YC, Bai YM, Chen JY, Lin CC, Lai LC, Liou YJ (2005) Polymorphism of the adrenergic receptor alpha 2a -1291 C>G genetic variation and clozapine-induced weight gain. J Neural Transm 112: 1463–1468.