Polyacrylamide-grafted-alginate-based pH-sensitive hydrogel beads for delivery of ketoprofen to the intestine: In vitro and in vivo evaluation

Journal of Biomaterials Science, Polymer Edition

Volumn 20, Issue 2, 2009, Pages 235-251

  Kulkarni, Raghavendra V ^a   Sa, Biswanath ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

Drug delivery; Graft co polymer; Ketoprofen; pH sensitive hydrogel; Stomach histopathology

Indexed keywords

ALKALINITY; CONTROLLED DRUG DELIVERY; CROSSLINKING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG DELIVERY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FREE RADICAL POLYMERIZATION; FREE RADICALS; GRAFT COPOLYMERS; GRAFTING (CHEMICAL); HYDROGELS; IONOTROPIC GELATION; PH SENSORS; SCANNING ELECTRON MICROSCOPY; SODIUM ALGINATE; TARGETED DRUG DELIVERY;

ALKALINE HYDROLYSIS; FOURIER TRANSFORM INFRA RED (FTIR) SPECTROSCOPY; KETOPROFEN; NITROGEN ATMOSPHERES; PH-SENSITIVE HYDROGEL; PULSATILE SWELLING; STOMACH HISTOPATHOLOGY; SWELLING STUDIES;

THERMOGRAVIMETRIC ANALYSIS;

ALGINIC ACID; KETOPROFEN; NITROGEN; POLYACRYLAMIDE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; DIFFERENTIAL SCANNING CALORIMETRY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG RELEASE; GELATION; HISTOPATHOLOGY; HYDROGEL; HYDROLYSIS; INFRARED SPECTROSCOPY; MALE; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; RAT; RAT STRAIN; SCANNING ELECTRON MICROSCOPY; STOMACH HEMORRHAGE; STOMACH MUCOSA; STOMACH MUCOSA INJURY; STOMACH PH; STOMACH PROTECTION; STOMACH ULCER; SYNTHESIS; TABLET FORMULATION; THERMOGRAVIMETRY;

RATTUS;

EID: 59649104142     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1163/156856209X404514     Document Type: Article

References (29)

1. H. Y. He and X. Cao, J. Control. Rel. 95, 391 (2004).
2. A. M. Lowman, M. Morishita and M. Kajita, J. Pharm. Sci. 88, 933 (1999).
3. M. Morishita, A. M. Lowman, K. Takayana, T. Nagai and N. A. Peppas, J. Control. Rel. 81, 25 (2002).
4. E. D. Pena, Q. Garrido and J. M. B. Rienda, Polymer 43, 4341 (2002).
5. K. S. Soppimath, T. M. Aminabhavi, A. M. Dave, S. G. Kumbar and W. E. Rudzinski, Drug Dev. Ind. Pharm. 28, 957 (2002).
6. H. Keles, M. Celik, M. Sacak and L. Aksu, J. Appl. Polym. Sci. 74, 1547 (1999).
7. H. Kaur and R. R. Chatterji, Macromolecules 23, 4868 (1990).
8. S. K. Rath and R. P. Singh, J. Appl. Polym. Sci. 70, 1795 (1998).
9. A. Desjardins, El-Jammal, A. Ferrada, A. Filiatrult and P. Ouadji, Proc. Int. Symp. Control. Release Bioact. Mater. 27, 1246 (2000).
10. A. Blandino, M. Macias and D. Cantero, Enzyme Microb. Techn. 27, 319 (2000).
11. G. Patel, Pharm. Formul. Quality 3, 51 (2006).
12. C. M. Setty, S. S. Sahoo and B. Sa, Drug Dev. Ind. Pharm. 31, 435 (2005).
13. A. Halder and B. Sa, AAPS Pharm. Sci. Tech. 7, 46 (2006).
14. A. Halder, S. Maiti and B. Sa, Int. J. Pharm. 302, 84 (2005).
15. A. Halder, S. Mukharjee and B. Sa, J. Microencapsul. 22, 67 (2005).
16. A. Pourjavadi, H. Ghasemzadeh and H. Hosseinzadeh, e-Polymers, 027 (2004).
17. A. Pourjavadi, M. Sadeghi and H. Hosseinzadeh, Polym. Adv. Technol. 15, 1 (2004).
18. T. Tripathy and R. P. Singh, Eur. Polym. J. 36, 1471 (2000).
19. V. Pillay and R. Fassihi, J. Control. Rel. 59, 229 (1999).
20. M. N. Ghosh, in: Fundamentals of Experimental Pharmacology, M. N. Ghosh (Ed.), p. 192. Hilton, Delhi (2005).
21. B. Arica, S. Calis, P. Atilla, N. T. Durlu, N. Caker, H. S. Kas and A. A. Hincal, J. Microencapsul. 22, 153 (2005).
22. Y. Murata, K. Nakada, E. Miyamoto, S. Kawashima and S. H. Seo, J. Control. Rel. 23, 21 (1993).
23. K. C. Gupta and M. N. V. Ravikumar, J. Appl. Polym. Sci. 76, 672 (2000).
24. G. Pasparakis and N. Bouropoulos, Int. J. Pharm. 323, 34 (2006).
25. R. C. Korsmeyer and N. A. Peppas, J. Membr. Sci. 9, 211 (1981).
26. F. E. I. Jianqi, Z. Zhang, L. Zhong and L. Gu, J. Appl. Polym. Sci. 85, 2423 (2002).
27. A. Nakhodchi and A. Tailor, Il Farmaco 59, 999 (2004).
28. P. L. Ritger and N. A. Peppas, J. Control. Rel. 5, 37 (1987).
29. J. K. Desai, R. K. Goyal and N. S. Parmar, Ind. J. Physiol. Pharmacol. 41, 3 (1997).