Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARδ agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 4, 2009, Pages 1101-1104

  Zhang, Rui ^a   DeAngelis, Alan ^a   Wang, Aihua ^a   Sieber McMaster, Ellen ^a   Li, Xun ^a   Russell, Ronald ^a   Pelton, Patricia ^a   Xu, Jun ^a   Zhu, Peifang ^a   Zhou, Lubing ^a   Demarest, Keith ^a   Murray, William V ^a   Kuo, Gee Hong ^a  

^a JOHNSON AND JOHNSON   (United States)

Author keywords

Achiral analogs; Dyslipidemic; Selective PPAR agonists

Indexed keywords

ACETIC ACID DERIVATIVE; ALKYL GROUP; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; THIOPHENE DERIVATIVE;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; GLYCOLATES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PPAR DELTA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 59649101365     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.113     Document Type: Article

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