Methylation and QTDT analysis of the 5-HT2A receptor 102C allele: Analysis of suicidality in major psychosis

Journal of Psychiatric Research

Volumn 43, Issue 5, 2009, Pages 532-537

  Luca, Vincenzo De ^a   Viggiano, Emanuela ^a   Dhoot, Ranbir ^a   Kennedy, James L ^a   Wong, Albert H C ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

5 HT2A; Allele ratio; Methylation; Post mortem brain; Psychoses; Suicide

Indexed keywords

DNA; SEROTONIN 2A RECEPTOR;

ALLELE; ARTICLE; BIPOLAR DISORDER; CAUSE OF DEATH; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; METHYLATION; PREFRONTAL CORTEX; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT;

EID: 59649086138     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2008.07.007     Document Type: Article

References (33)

1. Abdolmaleky H.M., Smith C.L., Faraone S.V., Shafa R., Stone W., Glatt S.J., et al. Methylomics in psychiatry: modulation of gene-environment interactions may be through DNA methylation. American Journal of Medical Genetics B Neuropsychiatry Genetics 127 (2004) 51-59
2. Abdolmaleky H.M., Thiagalingam S., and Wilcox M. Genetics and epigenetics in major psychiatric disorders: dilemmas, achievements, applications, and future scope. American Journal of Pharmacogenomics 5 (2005) 149-160
3. Abecasis G.R., Cardon L.R., and Cookson W.O. A general test of association for quantitative traits in nuclear families. American Journal of Human Genetics 66 (2000) 279-292
4. Afonina I.A., Reed M.W., Lusby E., Shishkina I.G., and Belousov Y.S. Minor groove binder-conjugated DNA probes for quantitative DNA detection by hybridization-triggered fluorescence. Biotechniques 32 4 (2002) 940-946 (940-4-946-9) 2002 April
5. Ahuja N., and Issa J.P. Aging, methylation and cancer. Histology and Histopathology 15 (2000) 835-842
6. Alonso-Aperte E., Ubeda N., Achon M., Perez-Miguelsanz J., and Varela-Moreiras G. Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation. Neurology 52 (1999) 750-756
7. Anguelova M., Benkelfat C., and Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II suicidal behavior. Molecular Psychiatry 8 (2003) 646-653
8. Arranz M., Collier D., Sodhi M., Ball D., Roberts G., Price J., et al. Association between clozapine response and allelic variation in 5-HT2A receptor gene. Lancet 346 (1995) 281-282
9. Attwood J.T., Yung R.L., and Richardson B.C. DNA methylation and the regulation of gene transcription. Cellular and Molecular Life Science 59 (2002) 241-257
10. Baldessarini R.J., and Hennen J. Genetics of suicide: an overview. Harvard Review of Psychiatry 12 (2004) 1-13
11. Bray N.J., Buckland P.R., Hall H., Owen M.J., and O'Donovan M.C. The serotonin-2A receptor gene locus does not contain common polymorphism affecting mRNA levels in adult brain. Molecular Psychiatry 9 (2004) 109-114
12. Chen Y.W., and Dilsaver S.C. Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders. Biological Psychiatry 39 (1996) 896-899
13. Chen Y., Sharma R.P., Costa R.H., Costa E., and Grayson D.R. On the epigenetic regulation of the human reelin promoter. Nucleic Acids Research 30 (2002) 2930-2939
14. De Luca V., Likhodi O., Kennedy J.L., and Wong A.H. Differential expression and parent-of-origin effect of the 5-HT2A receptor gene C102T polymorphism: analysis of suicidality in schizophrenia and bipolar disorder. American Journal of Medical Genetics B: Neuropsychiatry Genetics 144 (2007) 370-374
15. De Luca V., Zai G., Tharmalingam S., deBartolomeis A., Wong G., and Kennedy J.L. Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia. European Neuropsychopharmacology 16 4 (2005) 268-271
16. Du L., Bakish D., Lapierre Y.D., Ravindran A.V., and Hrdina P.D. Association of polymorphism of serotonin 2A receptor gene with suicidal ideation in major depressive disorder. American Journal of Medical Genetics 96 (2000) 56-60
17. Durtschi J.D., Stevenson J., Hymas W., and Voelkerding K.V. Evaluation of quantification methods for real-time PCR minor groove binding hybridization probe assays. Analytical Biochemistry 361 (2007) 55-64
18. Ertugrul A., Kennedy J.L., Masellis M., Basile V.S., Jayathilake K., and Meltzer H.Y. No association of the T102C polymorphism of the serotonin 2A receptor gene (HTR2A) with suicidality in schizophrenia. Schizophrenia Research 69 (2004) 301-305
19. Fukuda Y., Koga M., Arai M., Noguchi E., Ohtsuki T., Horiuchi Y., et al. Monoallelic and unequal allelic expression of the HTR2A gene in human brain and peripheral lymphocytes. Biological Psychiatry 60 (2006) 1331-1335
20. Goodwin F.K.J.K.R. Manic depressive - a definitive overview of bipolar disorder (1990), Oxford University Press, New York
21. Kaminsky Z.A., Assadzadeh A., Flanagan J., and Petronis A. Single nucleotide extension technology for quantitative site-specific evaluation of metC/C in GC-rich regions. Nucleic Acids Research 33 10 (2005) e95
22. Kato M.V., Shimizu T., Nagayoshi M., Kaneko A., Sasaki M.S., and Ikawa Y. Genomic imprinting of the human serotonin-receptor (HTR2) gene involved in development of retinoblastoma. American Journal of Human Genetics 59 (1996) 1084-1090
23. Lahiri D.K., and Nurnberger Jr. J.I. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Research 19 (1991) 5444
24. Meltzer H.Y. Suicide in schizophrenia, clozapine, and adoption of evidence-based medicine. Journal of Clinical Psychiatry 66 (2005) 530-533
25. Petronis A. The genes for major psychosis: aberrant sequence or regulation?. Neuropsychopharmacology 23 (2000) 1-12
26. Polesskaya O.O., and Sokolov B.P. Differential expression of the "C" and "T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. Journal of Neuroscience Research 67 (2002) 812-822
27. Polesskaya O.O., Aston C., and Sokolov B.P. Allele C-specific methylation of the 5-HT2A receptor gene: evidence for correlation with its expression and expression of DNA methylase DNMT1. Journal of Neuroscience Research 83 (2006) 362-373
28. Radomsky E.D., Haas G.L., Mann J.J., and Sweeney J.A. Suicidal behavior in patients with schizophrenia and other psychotic disorders. American Journal of Psychiatry 156 (1999) 1590-1595
29. Roy A., Mazonson A., and Pickar D. Attempted suicide in chronic schizophrenia. British Journal of Psychiatry 144 (1984) 303-306
30. Roy A., Segal N.L., and Sarchiapone M. Attempted suicide among living co-twins of twin suicide victims. American Journal of Psychiatry 152 (1995) 1075-1076
31. Turecki G., Briere R., Dewar K., Antonetti T., Lesage A.D., Seguin M., Chawky N., et al. Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide. American Journal of Psychiatry 156 (1999) 1456-1458
32. Weaver I.C., Cervoni N., Champagne F.A., DÁlessio A.C., Sharma S., Seckl J.R., Dymov S., Szyf M., and Meaney M.J. Epigenetic programming by maternal behaviour. Nature Neuroscience 7 8 (2004) 847-854
33. Zalsman G., Frisch A., Baruch-Movshovits R., Sher L., Michaelovsky E., King R.A., et al. Family-based association study of 5-HT(2A) receptor T102C polymorphism and suicidal behavior in Ashkenazi inpatient adolescents. International Journal of Adolescent Medical Health 17 (2005) 231-238