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Volumn 20, Issue 5, 2008, Pages 560-564

Management of granulosa cell tumour of the ovary

Author keywords

Granulosa cell tumours; Hormones; Ovarian neoplasms; Therapeutics; Tumour markers

Indexed keywords

ANASTROZOLE; BUSERELIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; FOLLITROPIN RECEPTOR; FORKHEAD TRANSCRIPTION FACTOR; FORMESTANE; G PROTEIN COUPLED RECEPTOR; GROWTH DIFFERENTIATION FACTOR 9; IMATINIB; INHIBIN; INHIBIN A; INHIBIN B; LEUPRORELIN; MEDROXYPROGESTERONE ACETATE; MEGESTROL; MUELLERIAN INHIBITING FACTOR; NILOTINIB; PLATINUM DERIVATIVE; PROTEIN FOXL2; STEROIDOGENIC FACTOR 1; TAMOXIFEN; TAXANE DERIVATIVE; TRANSCRIPTION FACTOR GATA 2; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR GATA 6; TUMOR MARKER; UNCLASSIFIED DRUG;

EID: 59649086035     PISSN: 10408746     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCO.0b013e328306316f     Document Type: Review
Times cited : (42)

References (51)
  • 1
    • 0037445186 scopus 로고    scopus 로고
    • Granulosa cell tumor of the ovary
    • Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary. J Clin Oncol 2003; 21:1180-1189.
    • (2003) J Clin Oncol , vol.21 , pp. 1180-1189
    • Schumer, S.T.1    Cannistra, S.A.2
  • 4
    • 33846556366 scopus 로고    scopus 로고
    • Prognostic factors responsible for survival in sex cord stromal tumors of the ovary: An analysis of 376 women
    • Zhang M, Cheung MK, Shin JY, et al. Prognostic factors responsible for survival in sex cord stromal tumors of the ovary: an analysis of 376 women. Gynecol Oncol 2007; 104:396-400.
    • (2007) Gynecol Oncol , vol.104 , pp. 396-400
    • Zhang, M.1    Cheung, M.K.2    Shin, J.Y.3
  • 5
    • 0030743165 scopus 로고    scopus 로고
    • Control of differentiation, transformation, and apoptosis in granulosa cells by oncogenes, oncoviruses, and tumor suppressor genes
    • Amsterdam A, Selvaraj N. Control of differentiation, transformation, and apoptosis in granulosa cells by oncogenes, oncoviruses, and tumor suppressor genes. Endocr Rev 1997; 18:435-461.
    • (1997) Endocr Rev , vol.18 , pp. 435-461
    • Amsterdam, A.1    Selvaraj, N.2
  • 6
    • 1842575779 scopus 로고    scopus 로고
    • Signalling pathways in the molecular pathogenesis of ovarian granulosa cell tumours
    • Fuller PJ, Chu S. Signalling pathways in the molecular pathogenesis of ovarian granulosa cell tumours. Trends Endocrinol Metab 2004; 15:122-128.
    • (2004) Trends Endocrinol Metab , vol.15 , pp. 122-128
    • Fuller, P.J.1    Chu, S.2
  • 7
    • 28744454443 scopus 로고    scopus 로고
    • High GATA-4 expression associates with aggressive behavior, whereas low anti-Mullerian hormone expression associates with growth potential of ovarian granulosa cell tumors
    • Anttonen M, Unkila-Kallio L, Leminen A, et al. High GATA-4 expression associates with aggressive behavior, whereas low anti-Mullerian hormone expression associates with growth potential of ovarian granulosa cell tumors. J Clin Endocrinol Metab 2005; 90:6529-6535.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6529-6535
    • Anttonen, M.1    Unkila-Kallio, L.2    Leminen, A.3
  • 8
    • 0036262871 scopus 로고    scopus 로고
    • FSH-regulated gene expression profiles in ovarian tumours and normal ovaries
    • Chu S, Rushdi S, Zumpe ET, et al. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Mol Hum Reprod 2002; 8:426-433.
    • (2002) Mol Hum Reprod , vol.8 , pp. 426-433
    • Chu, S.1    Rushdi, S.2    Zumpe, E.T.3
  • 9
    • 0024614795 scopus 로고
    • The cyclic AMP-mediated stimulation of cell proliferation
    • Dumont JE, Jauniaux JC, Roger PP. The cyclic AMP-mediated stimulation of cell proliferation. Trends Biochem Sci 1989; 14:67-71.
    • (1989) Trends Biochem Sci , vol.14 , pp. 67-71
    • Dumont, J.E.1    Jauniaux, J.C.2    Roger, P.P.3
  • 10
    • 0029961869 scopus 로고    scopus 로고
    • Vallar L Oncogenic role of heterotrimeric G proteins. Cancer Surv 1996; 27: 325-338.
    • Vallar L Oncogenic role of heterotrimeric G proteins. Cancer Surv 1996; 27: 325-338.
  • 11
    • 0024404145 scopus 로고
    • GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
    • Landis CA, Masters SB, Spada A, et al. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature 1989; 340:692-696.
    • (1989) Nature , vol.340 , pp. 692-696
    • Landis, C.A.1    Masters, S.B.2    Spada, A.3
  • 12
    • 0025127424 scopus 로고
    • Two G protein oncogenes in human endocrine tumors
    • Lyons J, Landis CA, Harsh G, et al. Two G protein oncogenes in human endocrine tumors. Science 1990; 249:655-659.
    • (1990) Science , vol.249 , pp. 655-659
    • Lyons, J.1    Landis, C.A.2    Harsh, G.3
  • 13
    • 15444339758 scopus 로고    scopus 로고
    • Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors
    • Fragoso MC, Latronico AC, Carvalho FM, et al. Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors. J Clin Endocrinol Metab 1998; 83:2074-2078.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2074-2078
    • Fragoso, M.C.1    Latronico, A.C.2    Carvalho, F.M.3
  • 14
    • 0033304929 scopus 로고    scopus 로고
    • Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors
    • Ligtenberg MJ, Siers M, Themmen AP, et al. Analysis of mutations in genes of the follicle-stimulating hormone receptor signaling pathway in ovarian granulosa cell tumors. J Clin Endocrinol Metab 1999; 84:2233-2234.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 2233-2234
    • Ligtenberg, M.J.1    Siers, M.2    Themmen, A.P.3
  • 16
    • 0031172816 scopus 로고    scopus 로고
    • Juvenile granulosa cell tumors of the ovary in children and adolescents: Results from 33 patients registered in a prospective cooperative study
    • Calaminus G, Wessalowski R, Harms D, Gobel U. Juvenile granulosa cell tumors of the ovary in children and adolescents: results from 33 patients registered in a prospective cooperative study. Gynecol Oncol 1997; 65: 447-452.
    • (1997) Gynecol Oncol , vol.65 , pp. 447-452
    • Calaminus, G.1    Wessalowski, R.2    Harms, D.3    Gobel, U.4
  • 17
    • 33646410139 scopus 로고    scopus 로고
    • Activating mutations of the stimulatory g protein in juvenile ovarian granulosa cell tumors: A new prognostic factor?
    • Kalfa N, Ecochard A, Patte C, et al. Activating mutations of the stimulatory g protein in juvenile ovarian granulosa cell tumors: a new prognostic factor? J Clin Endocrinol Metab 2006; 91:1842-1847.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1842-1847
    • Kalfa, N.1    Ecochard, A.2    Patte, C.3
  • 18
    • 34147185809 scopus 로고    scopus 로고
    • Extinction of FOXL2 expression in aggressive ovarian granulosa cell tumors in children
    • This article, together with the previous one from the same group [17, provides very interesting insights into the pathogeneisis of juvenile GCT
    • Kalfa N, Philibert P, Patte C, et al. Extinction of FOXL2 expression in aggressive ovarian granulosa cell tumors in children. Fertil Steril 2007; 87:896-901. This article, together with the previous one from the same group [17], provides very interesting insights into the pathogeneisis of juvenile GCT.
    • (2007) Fertil Steril , vol.87 , pp. 896-901
    • Kalfa, N.1    Philibert, P.2    Patte, C.3
  • 19
    • 34848849785 scopus 로고    scopus 로고
    • Forkhead transcription factors II
    • Tuteja G, Kaestner KH. Forkhead transcription factors II. Cell 2007; 131:192.
    • (2007) Cell , vol.131 , pp. 192
    • Tuteja, G.1    Kaestner, K.H.2
  • 20
    • 33745505572 scopus 로고    scopus 로고
    • Fox12 function in ovarian development
    • Uhlenhaut NH, Treier M. Fox12 function in ovarian development. Mol Genet Metab 2006; 88:225-234.
    • (2006) Mol Genet Metab , vol.88 , pp. 225-234
    • Uhlenhaut, N.H.1    Treier, M.2
  • 21
    • 0036964975 scopus 로고    scopus 로고
    • Inhibin-activin receptor subunit gene expression in ovarian tumors
    • Fuller PJ, Zumpe ET, Chu S, et al. Inhibin-activin receptor subunit gene expression in ovarian tumors. J Clin Endocrinol Metab 2002; 87:1395-1401.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1395-1401
    • Fuller, P.J.1    Zumpe, E.T.2    Chu, S.3
  • 22
    • 0027482490 scopus 로고
    • Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus luteum during the human menstrual cycle
    • Roberts VJ, Barth S, el-Roeiy A, Yen SS. Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus luteum during the human menstrual cycle. J Clin Endocrinol Metab 1993; 77:1402-1410.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1402-1410
    • Roberts, V.J.1    Barth, S.2    el-Roeiy, A.3    Yen, S.S.4
  • 23
    • 0033346803 scopus 로고    scopus 로고
    • Prospectively measured levels of serum follicle-stimulating hormone, estradiol, and the dimeric inhibins during the menopausal transition in a population-based cohort of women
    • Burger HG, Dudley EC, Hopper JL, et al. Prospectively measured levels of serum follicle-stimulating hormone, estradiol, and the dimeric inhibins during the menopausal transition in a population-based cohort of women. J Clin Endocrinol Metab 1999; 84:4025-4030.
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 4025-4030
    • Burger, H.G.1    Dudley, E.C.2    Hopper, J.L.3
  • 24
    • 0024455195 scopus 로고
    • Inhibin as a marker for granulosa-cell tumors
    • Lappohn RE, Burger HG, Bouma J, et al. Inhibin as a marker for granulosa-cell tumors. N Engl JMed 1989; 321:790-793.
    • (1989) N Engl JMed , vol.321 , pp. 790-793
    • Lappohn, R.E.1    Burger, H.G.2    Bouma, J.3
  • 26
    • 0029923588 scopus 로고    scopus 로고
    • Characterization of inhibin immunoreactivity in postmenopausal women with ovarian tumours
    • Burger HG, Robertson DM, Cahir N, et al. Characterization of inhibin immunoreactivity in postmenopausal women with ovarian tumours. Clin Endocrinol (Oxf) 1996; 44:413-418.
    • (1996) Clin Endocrinol (Oxf) , vol.44 , pp. 413-418
    • Burger, H.G.1    Robertson, D.M.2    Cahir, N.3
  • 27
    • 0032928143 scopus 로고    scopus 로고
    • Inhibin forms in serum from postmenopausal women with ovarian cancers
    • Robertson DM, Cahir N, Burger HG, et al. Inhibin forms in serum from postmenopausal women with ovarian cancers. Clin Endocrinol (Oxf) 1999; 50: 381-386.
    • (1999) Clin Endocrinol (Oxf) , vol.50 , pp. 381-386
    • Robertson, D.M.1    Cahir, N.2    Burger, H.G.3
  • 28
    • 0031733509 scopus 로고    scopus 로고
    • Inhibin B is the major form of inhibin/activin family secreted by granulosa cell tumors
    • Petraglia F, Luisi S, Pautier P, et al. Inhibin B is the major form of inhibin/activin family secreted by granulosa cell tumors. J Clin Endocrinol Metab 1998; 83: 1029-1032.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1029-1032
    • Petraglia, F.1    Luisi, S.2    Pautier, P.3
  • 29
    • 33947259001 scopus 로고    scopus 로고
    • Inhibin as a diagnostic marker for ovarian cancer
    • This recent study from the group that originally isolated inhibin provides a very useful overview of the current role of inhibin assays in GCT diagnosis and management
    • Robertson DM, Pruysers E, Jobling T. Inhibin as a diagnostic marker for ovarian cancer. Cancer Lett 2007; 249:14-17. This recent study from the group that originally isolated inhibin provides a very useful overview of the current role of inhibin assays in GCT diagnosis and management.
    • (2007) Cancer Lett , vol.249 , pp. 14-17
    • Robertson, D.M.1    Pruysers, E.2    Jobling, T.3
  • 30
    • 0031025263 scopus 로고    scopus 로고
    • The biological and immunological characterization of inhibin A and B forms in human follicular fluid and plasma
    • Robertson DM, Cahir N, Findlay JK, et al. The biological and immunological characterization of inhibin A and B forms in human follicular fluid and plasma. J Clin Endocrinol Metab 1997; 82:889-896.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 889-896
    • Robertson, D.M.1    Cahir, N.2    Findlay, J.K.3
  • 31
    • 0037204683 scopus 로고    scopus 로고
    • Inhibins/activins as diagnostic markers for ovarian cancer
    • Robertson DM, Stephenson T, Pruysers E, et al. Inhibins/activins as diagnostic markers for ovarian cancer. Mol Cell Endocrinol 2002; 191:97-103.
    • (2002) Mol Cell Endocrinol , vol.191 , pp. 97-103
    • Robertson, D.M.1    Stephenson, T.2    Pruysers, E.3
  • 32
    • 34247097444 scopus 로고    scopus 로고
    • Granulosa cell tumors of the ovary: The clinical value of serum inhibin A and B levels in a large single center cohort
    • A large study confirming previous findings which demonstrates the value of serum inhibin measurement in the follow-up of GCT
    • Mom CH, Engelen MJA, Willemse PHB, et al. Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort. Gynecol Oncol 2007; 105:365-372. A large study confirming previous findings which demonstrates the value of serum inhibin measurement in the follow-up of GCT.
    • (2007) Gynecol Oncol , vol.105 , pp. 365-372
    • Mom, C.H.1    Engelen, M.J.A.2    Willemse, P.H.B.3
  • 33
    • 0032920905 scopus 로고    scopus 로고
    • Combined inhibin and CA125 assays in the detection of ovarian cancer
    • Robertson DM, Cahir N, Burger HG, et al. Combined inhibin and CA125 assays in the detection of ovarian cancer. Clin Chem 1999; 45:651-658.
    • (1999) Clin Chem , vol.45 , pp. 651-658
    • Robertson, D.M.1    Cahir, N.2    Burger, H.G.3
  • 34
    • 0035974441 scopus 로고    scopus 로고
    • Development of an inhibin alpha subunit ELISA with broad specificity
    • Robertson DM, Stephenson T, Cahir N, et al. Development of an inhibin alpha subunit ELISA with broad specificity. Mol Cell Endocrinol 2001; 180:79-86.
    • (2001) Mol Cell Endocrinol , vol.180 , pp. 79-86
    • Robertson, D.M.1    Stephenson, T.2    Cahir, N.3
  • 35
    • 0036174140 scopus 로고    scopus 로고
    • Characterization of inhibin forms and their measurement by an inhibin alpha-subunit ELISA in serum from postmenopausal women with ovarian cancer
    • Robertson DM, Stephenson T, Pruysers E, et al. Characterization of inhibin forms and their measurement by an inhibin alpha-subunit ELISA in serum from postmenopausal women with ovarian cancer. J Clin Endocrinol Metab 2002; 87:816-824.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 816-824
    • Robertson, D.M.1    Stephenson, T.2    Pruysers, E.3
  • 36
    • 0026609778 scopus 로고
    • Mullerian inhibiting substance as a marker for ovarian sex-cord tumor
    • Gustafson ML, Lee MM, Scully RE, et al. Mullerian inhibiting substance as a marker for ovarian sex-cord tumor. N Engl J Med 1992; 326:466-471.
    • (1992) N Engl J Med , vol.326 , pp. 466-471
    • Gustafson, M.L.1    Lee, M.M.2    Scully, R.E.3
  • 37
    • 0032586769 scopus 로고    scopus 로고
    • Diagnostic utility of Mullerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors
    • Lane AH, Lee MM, Fuller AF Jr, et al. Diagnostic utility of Mullerian inhibiting substance determination in patients with primary and recurrent granulosa cell tumors. Gynecol Oncol 1999; 73:51-55.
    • (1999) Gynecol Oncol , vol.73 , pp. 51-55
    • Lane, A.H.1    Lee, M.M.2    Fuller Jr, A.F.3
  • 38
    • 17744376762 scopus 로고    scopus 로고
    • Detection of minimal levels of serum anti-Müllerian hormone during follow-up of patients with ovarian granulosa cell tumor by means of a highly sensitive enzyme-linked immunosorbent assay
    • Long WQ, Ranchin V, Pautier P, et al. Detection of minimal levels of serum anti-Müllerian hormone during follow-up of patients with ovarian granulosa cell tumor by means of a highly sensitive enzyme-linked immunosorbent assay. J Clin Endocrinol Metab 2000; 85:540-544.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 540-544
    • Long, W.Q.1    Ranchin, V.2    Pautier, P.3
  • 39
    • 0029664887 scopus 로고    scopus 로고
    • Antimüllerian hormone as a serum marker of granulosa cell tumors of the ovary: Comparative study with serum alpha-inhibin and estradiol
    • Rey RA, Lhomme C, Marcillac I, et al. Antimüllerian hormone as a serum marker of granulosa cell tumors of the ovary: comparative study with serum alpha-inhibin and estradiol. Am J Obstet Gynecol 1996; 174:958-965.
    • (1996) Am J Obstet Gynecol , vol.174 , pp. 958-965
    • Rey, R.A.1    Lhomme, C.2    Marcillac, I.3
  • 40
    • 34347218225 scopus 로고    scopus 로고
    • The anti-Müllerian hormone and ovarian cancer
    • A useful overview of the potential use of anti-Müllerian hormone in the management of ovarian cancer
    • La Marca A, Volpe A. The anti-Müllerian hormone and ovarian cancer. Hum Reprod Update 2007; 13:265-273. A useful overview of the potential use of anti-Müllerian hormone in the management of ovarian cancer.
    • (2007) Hum Reprod Update , vol.13 , pp. 265-273
    • La Marca, A.1    Volpe, A.2
  • 41
    • 33750164664 scopus 로고    scopus 로고
    • Anastrozole therapy in recurrent ovarian adult granulosa cell tu mors: A report of 2 cases
    • Freeman SA, Modesitt S C. Anastrozole therapy in recurrent ovarian adult granulosa cell tu mors: a report of 2 cases. Gynecol Oncol 2006; 103:755-758.
    • (2006) Gynecol Oncol , vol.103 , pp. 755-758
    • Freeman, S.A.1    Modesitt, S.C.2
  • 42
    • 13844276003 scopus 로고    scopus 로고
    • Hormonal treatment of a recurrent granulosa cell tumor of the ovary: Case report and review of the literature
    • Hardy RD, Bell JG, Nicely CJ, Reid GC. Hormonal treatment of a recurrent granulosa cell tumor of the ovary: case report and review of the literature. Gynecol Oncol 2005; 96:865-869.
    • (2005) Gynecol Oncol , vol.96 , pp. 865-869
    • Hardy, R.D.1    Bell, J.G.2    Nicely, C.J.3    Reid, G.C.4
  • 43
    • 0031718161 scopus 로고    scopus 로고
    • Granulosa cell tumours of the ovary: Demographics, survival and the management of advanced disease
    • Savage P, Constenla D, Fisher C, et al. Granulosa cell tumours of the ovary: demographics, survival and the management of advanced disease. Clin Oncol (R Coll Radiol) 1998; 10:242-245.
    • (1998) Clin Oncol (R Coll Radiol) , vol.10 , pp. 242-245
    • Savage, P.1    Constenla, D.2    Fisher, C.3
  • 44
    • 0028338269 scopus 로고
    • Failure of gonadotropin releasing hormone therapy in patients with metastatic ovarian sex cord stromal tumors
    • Maxwell GL, Soisson AP, Miles P. Failure of gonadotropin releasing hormone therapy in patients with metastatic ovarian sex cord stromal tumors. Oncology 1994; 51:356-359.
    • (1994) Oncology , vol.51 , pp. 356-359
    • Maxwell, G.L.1    Soisson, A.P.2    Miles, P.3
  • 45
    • 0034455165 scopus 로고    scopus 로고
    • Estrogen receptor isoform gene expression in ovarian stromal and epithelial tumors
    • Chu S, Mamers P, Burger HG, Fuller PJ. Estrogen receptor isoform gene expression in ovarian stromal and epithelial tumors. J Clin Endocrinol Metab 2000; 85:1200-1205.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 1200-1205
    • Chu, S.1    Mamers, P.2    Burger, H.G.3    Fuller, P.J.4
  • 46
    • 3442884828 scopus 로고    scopus 로고
    • Transrepression of estrogen receptor beta signaling by nuclear factor-kappab in ovarian granulosa cells
    • Chu S, Nishi Y, Yanase T, et al. Transrepression of estrogen receptor beta signaling by nuclear factor-kappab in ovarian granulosa cells. Mol Endocrinol 2004; 18:1919-1928.
    • (2004) Mol Endocrinol , vol.18 , pp. 1919-1928
    • Chu, S.1    Nishi, Y.2    Yanase, T.3
  • 48
    • 4243753256 scopus 로고    scopus 로고
    • Successful treatment of a patient with a granulosa/theca cell tumor of the ovary with STI571 (Gleevic) [Abstract 1904]
    • Jakob A, Geiger R, Freidrich WH. Successful treatment of a patient with a granulosa/theca cell tumor of the ovary with STI571 (Gleevic) [Abstract 1904]. Proc Am Soc Clin Oncol 2002; 21:24b.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Jakob, A.1    Geiger, R.2    Freidrich, W.H.3
  • 49
    • 37449013816 scopus 로고    scopus 로고
    • Expression, mutational analysis and in vitro response of imatinib mesylate and nilotinib target genes in ovarian granulosa cell tumors
    • This study from our own group raises the possibility that targeted therapy with an appropriate TKI may have a role in the treatment of GCTs
    • Chu S, Alexiadis M, Fuller PJ. Expression, mutational analysis and in vitro response of imatinib mesylate and nilotinib target genes in ovarian granulosa cell tumors. Gynecol Oncol 2008; 108:182-190. This study from our own group raises the possibility that targeted therapy with an appropriate TKI may have a role in the treatment of GCTs.
    • (2008) Gynecol Oncol , vol.108 , pp. 182-190
    • Chu, S.1    Alexiadis, M.2    Fuller, P.J.3
  • 50
    • 0036635291 scopus 로고    scopus 로고
    • Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug
    • Capdeville R, Buchdunger E, Zimmermann J, et al. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug. Nat Rev Drug Discov 2002; 1:493-502.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 493-502
    • Capdeville, R.1    Buchdunger, E.2    Zimmermann, J.3
  • 51
    • 0032961633 scopus 로고    scopus 로고
    • Overexpression of macrophage colony-stimulating factor (CSF-1) and its receptor, c-fms, in normal ovarian granulosa cells leads to cell proliferation and tumorigenesis
    • Keshava N, Gubba S, Tekmal RR. Overexpression of macrophage colony-stimulating factor (CSF-1) and its receptor, c-fms, in normal ovarian granulosa cells leads to cell proliferation and tumorigenesis. J Soc Gynecol Investig 1999; 6:41-49.
    • (1999) J Soc Gynecol Investig , vol.6 , pp. 41-49
    • Keshava, N.1    Gubba, S.2    Tekmal, R.R.3


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