Chapter 12 Monitoring the Autophagy Pathway in Cancer

Methods in Enzymology

Volumn 453, Issue C, 2009, Pages 251-271

  Dorsey, Frank C ^a   Steeves, Meredith A ^a   Prater, Stephanie M ^a   Schröter, Thomas ^a   Cleveland, John L ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; ORNITHINE DECARBOXYLASE; MAP1LC3 PROTEIN, MOUSE; RECOMBINANT PROTEIN;

AUTOPHAGY; CELL ISOLATION; CELL PH; EX VIVO STUDY; FETUS LIVER; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE MICROSCOPY; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEP 2 CELL; HIGH THROUGHPUT SCREENING; HUMAN; IN VIVO STUDY; LIVER TRANSPLANTATION; LYMPHOMA; LYSOSOME; NEOPLASM; NONHUMAN; PHAGOSOME; PRECANCER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DOMAIN; REAL TIME ECHOGRAPHY; REVIEW; TUMOR GROWTH; ANIMAL; ARTICLE; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; AUTOPHAGY; GREEN FLUORESCENT PROTEINS; LYMPHOMA; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASMS; RECOMBINANT PROTEINS;

EID: 59649084881     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(08)04012-3     Document Type: Review

References (35)

1. Abida W.M., and Gu W. p53-Dependent and p53-independent activation of autophagy by ARF. Cancer Res. 68 2 (2008) 352-357
2. Adams J.M., Harris A.W., et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318 6046 (1985) 533-538
3. Alpdogan O., Muriglan S.J., et al. IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation. J. Clin. Invest. 112 7 (2003) 1095-1107
4. Alt J.R., Greiner T.C., et al. Mdm2 haploinsufficiency profoundly inhibits Myc-induced lymphomagenesis. EMBO J. 22 6 (2003) 1442-1450
5. Amaravadi R.K., Yu D., et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J. Clin. Invest. 117 2 (2007) 326-336
6. Briceno E., Reyes S., et al. Therapy of glioblastoma multiforme improved by the anti-mutagenic chloroquine. Neurosurg. Focus 14 2 (2003) e3
7. Carew J.S., Nawrocki S.T., et al. Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 110 1 (2007) 313-322
8. Ciechomska I.A., and Tolkovsky A.M. Non-autophagic GFP-LC3 puncta induced by saponin and other detergents. Autophagy 3 6 (2007) 586-590
9. Degenhardt K., Mathew R., et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10 1 (2006) 51-64
10. Eischen C.M., Weber J.D., et al. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 13 20 (1999) 2658-2669
11. Fan F., and Wood K.V. Bioluminescent assays for high-throughput screening. Assay Drug Dev. Technol. 5 1 (2007) 127-136
12. Feng Z., Zhang H., et al. The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl. Acad. Sci. USA 102 23 (2005) 8204-8209
13. Hawley R.G., Fong A.Z., et al. Transplantable myeloproliferative disease induced in mice by an interleukin 6 retrovirus. J. Exp. Med. 176 4 (1992) 1149-1163
14. Ichimura Y., Kirisako T., et al. A ubiquitin-like system mediates protein lipidation. Nature 408 6811 (2000) 488-492
15. Kabeya Y., Mizushima N., et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19 21 (2000) 5720-5728
16. Karin M., and Greten F.R. NF-κB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5 10 (2005) 749-759
17. Kirisako T., Ichimura Y., et al. The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. J. Cell. Biol. 151 2 (2000) 263-276
18. Klionsky D.J., Abeliovich H., et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4 2 (2008) 151-175
19. Kuma A., Matsui M., et al. LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy 3 4 (2007) 323-328
20. Liang X.H., Jackson S., et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402 6762 (1999) 672-676
21. Lowe S.W., and Sherr C.J. Tumor suppression by Ink4a-Arf: progress and puzzles. Curr. Opin. Genet. Dev. 13 1 (2003) 77-83
22. Luo J.L., Maeda S., et al. Inhibition of NF-κB in cancer cells converts inflammation-induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression. Cancer Cell 6 3 (2004) 297-305
23. Maclean K.H., Dorsey F.C., et al. Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J. Clin. Invest. 118 1 (2008) 79-88
24. Marino G., Salvador-Montoliu N., et al. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J. Biol. Chem. 282 25 (2007) 18573-18583
25. Mathew R., Karantza-Wadsworth V., et al. Role of autophagy in cancer. Nat. Rev. Cancer 7 12 (2007) 961-967
26. Mathew R., Kongara S., et al. Autophagy suppresses tumor progression by limiting chromosomal instability. Genes Dev. 21 11 (2007) 1367-1381
27. Mizushima N., Kuma A., et al. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J. Cell Sci. 116 Pt 9 (2003) 1679-1688
28. Mizushima N., Yamamoto A., et al. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol. Biol. Cell 15 3 (2004) 1101-1111
29. Qu X., Yu J., et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 112 12 (2003) 1809-1820
30. Reef S., Zalckvar E., et al. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. Mol. Cell 22 4 (2006) 463-475
31. Schmitt C.A., Fridman J.S., et al. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell 1 3 (2002) 289-298
32. Sherr C.J. Divorcing ARF and p53: an unsettled case. Nat. Rev. Cancer 6 9 (2006) 663-673
33. Sotelo J., Briceno E., et al. Adding chloroquine to conventional treatment for glioblastoma multiforme: A randomized, double-blind, placebo-controlled trial. Ann. Intern. Med. 144 5 (2006) 337-343
34. Tanida I., Ueno T., et al. LC3 conjugation system in mammalian autophagy. Int. J. Biochem. Cell Biol. 36 12 (2004) 2503-2518
35. Yue Z., Jin S., et al. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. USA 100 25 (2003) 15077-15082