Preservation of natural stability of fruit "bromelain" from ananas comosus (pineapple)

Journal of Food Biochemistry

Volumn 33, Issue 1, 2009, Pages 1-19

  Bhattacharya, R ^a   Bhattacharyya, D ^a  

^a Indian Institut of Chemical Biology   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANANAS COMOSUS;

EID: 59549107722     PISSN: 01458884     EISSN: 17454514     Source Type: Journal    
DOI: 10.1111/j.1745-4514.2008.00194.x     Document Type: Article

References (27)

1. BALAKRISHNAN, V., HAREENDRAN, A. SUKUMARAN, N.C. 1981. Double-blind cross-over trial of an enzyme preparation in pancreatic steatorrhea. J. Asso. Physicians India 29, 207 209.
2. BATKIN, S., TAUSSIG, S.J. SZEKEREZES J. 1988. Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity. J. Cancer Res. Clin. Oncol. 114, 507 508.
3. CZERKINSKY, C.C., NILSSON, L., NYGREN, H., OUCHTERLONY, O. TARKOWSKI, A. 1983. A solid-phase enzyme-linked immunospot (ELISPOT) assay for enumeration of specific antibody-secreting cells. J. Immunol. Methods 65, 109 121.
4. DESSER, L., REHBERGER, A., KOKRON, E. PAUKOVITS, W. 1993. Cytokine synthesis in human peripheral blood mononuclear cells after oral administration of polyenzyme preparations. Oncology 50, 403 407.
5. DEUTSCHER, M.P. 1990. Maintaining protein stability. Methods Enzymol. 182, 83 89.
6. ENGWERDA, C.R., ANDREW, D., LADHAMS, A. MYNOTT, T.L. 2001. Bromelain modulates T cell and B cell immune responses in vitro and in vivo. Cell. Immunol. 210, 66 75.
7. FALANGA, V. 2002. Wound bed preparation and the role of enzymes: A case for multiple actions of therapeutic agents. Wounds 14, 47 57.
8. FRAZIER, W.C. 1958. Preservation of fruits and fruit products. In Food Microbiology, pp. 177 181, McGraw-Hill Book Company, Inc., New York.
9. GERARD, G. 1972. Anti-cancer therapy with bromelain. Agressologie 13, 261 274.
10. HALE, L.P. HAYNES, B.F. 1992. Bromelain treatment of human T cells removes CD44, CD45RA, E2/MIC2, CD6, CD7, CD8, and Leu 8/LAM1 surface molecules and markedly enhances CD2-mediated T cell activation. J. Immunol. 149, 3809 3816.
11. HALE, L.P., GREER, P.K., TRINH, C.T. JAMES, C.L. 2005. Proteinase activity and stability of natural bromelain preparations. Int. Immunopharmacol. 5, 783 793.
12. JERNE, N.K. NORDIN, A.A. 1963. Plaque formation in agar by single antibody producing cells. Science 140, 405.
13. KNILL-JONES, R.P., PEARCE, H. BATTEN, J. 1970. Comparative trial of Nutrizym in chronic pancreatic insufficiency. Brit. Med. J. 4, 21 24.
14. MASSON, M. 1995. Bromelain in blunt injuries of the locomotor system. A study of observed applications in general practice. Fortschr. Med 113, 303 306.
15. MAURER, H.R. 2000. Bromelain: Biochemistry pharmacology and medical use. Cell. Mol. Life Sci. 58, 1234 1245.
16. MYNOTT, T.L., LUKE, R.K.J. CHANDLER, D.S. 1996. Oral administration of protease inhibits enterotoxigenic Escherichia coli receptor in piglet small intestine. Gut 38, 28 32.
17. MYNOTT, T.L., GUANDALINI, S., RAIMONDI, F. FASANO, A. 1997. Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro. Gastroenterology 113, 175 181.
18. NIEPER, H.A. 1974. A program for the treatment of cancer. Krebs 6, 124 127.
19. PÜTTER, J. 1974. Peroxidases. In Methods of Enzymatic Analysis, 2nd Ed., Vol. 2 (H.V. Bergmeyer, ed.) pp. 685 690, Academic Press Inc., New York.
20. RICK, W. STEGBAUER, H.P. 1974 Amylase. Measurement of reducing groups. In Methods of Enzymatic Analysis, 2nd Ed., Vol. 2 (H.V. Bergmeyer, ed.) pp. 885 890, Academic Press Inc., New York, NY.
21. ROWAN, A.D. BUTTLE, D.J. 1994. Pineapple cysteine endopeptidases. Methods Enzymol. 244, 55 68.
22. SARATH, G., MOTTE, R.S.D.L. WAGNER, F.W. 1996. Protease assay methods. In Proteolytic Enzymes: A Practical Approach (R.J. Beynon J.S. Bond, eds.) pp. 25 55, IRL Press at Oxford University Press, Oxford.
23. SASAKI, M., TAKEDA, S., KATO, T. MATSUBA, K. 1980. Antigenicities of stem bromelain: Contribution of three-dimensional structure and individual amino acid residues. J. Biochem. 87, 817 824.
24. TASSMAN, G.C., ZAFRAN, J.N. ZAYNON, G.M. 1964. Evaluation of a plant proteolytic enzyme for the control of inflammation and pain. J. Dent. Med. 19, 73 77.
25. TASSMAN, G.C., ZAFRAN, J.N. ZAYNON, G.M. 1965. A double-blind crossover study of a plant proteolytic enzyme in oral surgery. J. Dent. Med. 20, 51 54.
26. TAUSSIG, S.J., SZEKERCZES, J. BATKIN, S. 1985. Inhibition of tumor growth in vitro by bromelain, an extract of the pineapple plant (Ananas comosus). Planta. Med. 6, 538 539.
27. WALTER, K. SCHÜTT, C. 1974. Phosphatases. In Methods of Enzymatic Analysis, 2nd Ed. Vol. 2 (H.V. Bergmeyer, ed.) pp. 856 875, Academic Press Inc., New York.