Hyperglycaemia is associated with changes in the regional concentrations of glucose and myo-inositol within the brain

Diabetologia

Volumn 52, Issue 3, 2009, Pages 534-540

  Heikkila O ^a,b   Lundbom, N ^a   Timonen, M ^a   Groop, P H ^a,b   Heikkinen, S ^a   Makimattila S ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Brain metabolism; Glucose; Magnetic resonance spectroscopy; Myo inositol; N Acetylaspartate; Type 1 diabetes

Indexed keywords

CHOLINE; CREATININE; GLUCOSE; INOSITOL; N ACETYLASPARTIC ACID;

ADULT; ARTICLE; BRAIN LEVEL; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FRONTAL CORTEX; GLUCOSE BLOOD LEVEL; GLUCOSE BRAIN LEVEL; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; THALAMUS; WHITE MATTER;

ADULT; BLOOD GLUCOSE; BLOOD PRESSURE; BODY MASS INDEX; BRAIN; C-REACTIVE PROTEIN; CHOLESTEROL, HDL; DIABETES MELLITUS, TYPE 1; GLUCOSE; HEART RATE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPERGLYCEMIA; INOSITOL; LIPIDS; MAGNETIC RESONANCE IMAGING; MALE; PATIENT SELECTION; REFERENCE VALUES; YOUNG ADULT;

EID: 59449089439     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-008-1242-2     Document Type: Article

References (45)

1. AL McCall 1992 The impact of diabetes on the CNS Diabetes 41 557 570
2. B van Harten FE de Leeuw HC Weinstein P Scheltens GJ Biessels 2006 Brain imaging in patients with diabetes: a systematic review Diabetes Care 29 2539 2548
3. AM Brands GJ Biessels EH de Haan LJ Kappelle RP Kessels 2005 The effects of type 1 diabetes on cognitive performance: a meta-analysis Diabetes Care 28 726 735
4. B Keymeulen A Jacobs K de Metz C de Sadeleer A Bossuyt G Somers 1995 Regional cerebral hypoperfusion in long-term type 1 (insulin-dependent) diabetic patients: relation to hypoglycaemic events Nucl Med Commun 16 10 16
5. 99mTc-HMPAO SPET in type I diabetic patients with no clinical history of cerebrovascular disease Eur J Nucl Med 24 1507 1513
6. SP Laing AJ Swerdlow LM Carpenter 2003 Mortality from cerebrovascular disease in a cohort of 23 000 patients with insulin-treated diabetes Stroke 34 418 421
7. DM Nathan PA Cleary JY Backlund 2005 Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes N Engl J Med 353 2643 2653
8. G Musen IK Lyoo CR Sparks 2006 Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry Diabetes 55 326 333
9. AM Wessels S Simsek PL Remijnse 2006 Voxel-based morphometry demonstrates reduced grey matter density on brain MRI in patients with diabetic retinopathy Diabetologia 49 2474 2480
10. AM Wessels P Scheltens F Barkhof RJ Heine 2008 Hyperglycaemia as a determinant of cognitive decline in patients with type 1 diabetes Eur J Pharmacol 585 88 96
11. DJ Cox BP Kovatchev LA Gonder-Frederick 2005 Relationships between hyperglycemia and cognitive performance among adults with type 1 and type 2 diabetes Diabetes Care 28 71 77
12. H Vrenken F Barkhof BM Uitdehaag JA Castelijns CH Polman PJ Pouwels 2005 MR spectroscopic evidence for glial increase but not for neuro-axonal damage in MS normal-appearing white matter Magn Reson Med 53 256 266
13. K Sarac A Akinci A Alkan M Aslan T Baysal C Ozcan 2005 Brain metabolite changes on proton magnetic resonance spectroscopy in children with poorly controlled type 1 diabetes mellitus Neuroradiology 47 562 565
14. SL Wootton-Gorges NS Glaser 2007 Imaging of the brain in children with type I diabetes mellitus Pediatr Radiol 37 863 869
15. R Kreis BD Ross 1992 Cerebral metabolic disturbances in patients with subacute and chronic diabetes mellitus: detection with proton MR spectroscopy Radiology 184 123 130
16. S Mäkimattila K Malmberg-Ceder AM Häkkinen 2004 Brain metabolic alterations in patients with type 1 diabetes-hyperglycemia-induced injury J Cereb Blood Flow Metab 24 1393 1399
17. FJ Cameron MJ Kean RM Wellard GA Werther JJ Neil TE Inder 2005 Insights into the acute cerebral metabolic changes associated with childhood diabetes Diabet Med 22 648 653
18. A Geissler R Frund J Scholmerich S Feuerbach B Zietz 2003 Alterations of cerebral metabolism in patients with diabetes mellitus studied by proton magnetic resonance spectroscopy Exp Clin Endocrinol Diabetes 111 421 427
19. AB Criego I Tkac A Kumar W Thomas R Gruetter ER Seaquist 2005 Brain glucose concentrations in patients with type 1 diabetes and hypoglycemia unawareness J Neurosci Res 79 42 47
20. MD Davis MR Fisher RE Gangnon 1998 Risk factors for high-risk proliferative diabetic retinopathy and severe visual loss: Early Treatment Diabetic Retinopathy Study Report #18 Invest Ophthalmol Vis Sci 39 233 252
21. EA McGuire JH Helderman JD Tobin R Andres M Berman 1976 Effects of arterial versus venous sampling on analysis of glucose kinetics in man J Appl Physiol 41 565 573
22. AS Urrila A Hakkarainen S Heikkinen 2006 Preliminary findings of proton magnetic resonance spectroscopy in occipital cortex during sleep deprivation Psychiatry Res 147 41 46
23. WT Friedewald RI Levy DS Fredrickson 1972 Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clin Chem 18 499 502
24. MJ Campbell SA Julious DG Altman 1995 Estimating sample sizes for binary, ordered categorical, and continuous outcomes in two group comparisons BMJ 311 1145 1148
25. SC Ferguson A Blane J Wardlaw 2005 Influence of an early-onset age of type 1 diabetes on cerebral structure and cognitive function Diabetes Care 28 1431 1437
26. EJ Schoenle D Schoenle L Molinari RH Largo 2002 Impaired intellectual development in children with type I diabetes: association with HbA(1c), age at diagnosis and sex Diabetologia 45 108 114
27. NL Rasgon MA Thomas BH Guze 2001 Menstrual cycle-related brain metabolite changes using 1H magnetic resonance spectroscopy in premenopausal women: a pilot study Psychiatry Res 106 47 57
28. NB Lincoln RM Faleiro C Kelly BA Kirk WJ Jeffcoate 1996 Effect of long-term glycemic control on cognitive function Diabetes Care 19 656 658
29. CM Ryan MO Geckle TJ Orchard 2003 Cognitive efficiency declines over time in adults with type 1 diabetes: effects of micro- and macrovascular complications Diabetologia 46 940 948
30. SC Ferguson A Blane P Perros 2003 Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia Diabetes 52 149 156
31. CM Ryan TM Williams DN Finegold TJ Orchard 1993 Cognitive dysfunction in adults with type 1 (insulin-dependent) diabetes mellitus of long duration: effects of recurrent hypoglycaemia and other chronic complications Diabetologia 36 329 334
32. E Bonora 2006 The metabolic syndrome and cardiovascular disease Ann Med 38 64 80
33. C Li B Hedblad M Rosvall F Buchwald FA Khan G Engstrom 2008 Stroke incidence, recurrence, and case-fatality in relation to socioeconomic position: a population-based study of middle-aged Swedish men and women Stroke 39 2191 2196
34. ER Seaquist GS Damberg I Tkac R Gruetter 2001 The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/metabolism in humans Diabetes 50 2203 2209
35. WD Heiss B Habedank JC Klein 2004 Metabolic rates in small brain nuclei determined by high-resolution PET J Nucl Med 45 1811 1815
36. 13C] magnetic resonance spectroscopy at 4.1T J Cereb Blood Flow Metab 19 1179 1188
37. RA de Graaf JW Pan F Telang 2001 Differentiation of glucose transport in human brain gray and white matter J Cereb Blood Flow Metab 21 483 492
38. F Eisenberg Jr R Parthasarathy 1987 Measurement of biosynthesis of myo-inositol from glucose 6-phosphate Methods Enzymol 141 127 143
39. B Ross S Bluml 2001 Magnetic resonance spectroscopy of the human brain Anat Rec 265 54 84
40. +/myo-inositol cotransport in rat cortical astrocytes Glia 12 35 43
41. J Urenjak SR Williams DG Gadian M Noble 1992 Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro J Neurochem 59 55 61
42. ML Simmons CG Frondoza JT Coyle 1991 Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies Neuroscience 45 37 45
43. JR Moffett B Ross P Arun CN Madhavarao AM Namboodiri 2007 N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology Prog Neurobiol 81 89 131
44. AM Wessels SA Rombouts PL Remijnse 2007 Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume Diabetologia 50 1763 1769
45. CT Kodl DT Franc JP Rao 2008 Diffusion tensor imaging (DTI) identifies deficits in white matter microstructure in subjects with type 1 diabetes mellitus that correlate with reduced neurocognitive function Diabetes 57 3083 3089