Central administration of Orphanin FQ inhibits GnRH secretion by ORL1 receptor in the median eminence of freely moving ovariectomized rats

Neuroscience Bulletin

Volumn 25, Issue 1, 2009, Pages 1-6

  An, Xiao Fei ^a,b   He, Ming ^b   Feng, Yi ^b   Feng, Hao ^b   Yu, Jiang Yi ^a  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

Gonadotropin releasing hormone; Luteinizing hormone; Median eminence; Orphanin FQ

Indexed keywords

GONADORELIN; NOCICEPTIN; OPIATE ANTAGONIST; OPIATE RECEPTOR; OPIATE RECEPTOR LIKE 1 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN PERFUSION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GONADORELIN RELEASE; HYPOTHALAMUS; MEDIAN EMINENCE; NONHUMAN; OVARIECTOMY; PROTEIN SECRETION; RADIOIMMUNOASSAY; RAT;

ANALYSIS OF VARIANCE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GONADOTROPIN-RELEASING HORMONE; MEDIAN EMINENCE; OPIOID PEPTIDES; OVARIECTOMY; PEPTIDE FRAGMENTS; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; SECRETORY PATHWAY; VASODILATOR AGENTS; WAKEFULNESS;

EID: 59449087902     PISSN: 16737067     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12264-009-1119-5     Document Type: Article

References (20)

1. R.K. Reinscheid H.P. Nothacker A. Bourson A. Ardati R.A. Henningsem J.R. Bunzow 1995 Orphanin FQ: a neuropeptide that activates an opioid-like G protein-coupled receptor Science 270 792 794
2. J.C. Meunier C. Mollereau L. Toll C. Suaudeau C. Moisand P. Alvinerie 1995 Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor Nature 377 532 535
3. G. Calo R. Guerrini A. Rizzi S. Salvadori D. Regoli 2000 Pharmacology of nociceptin and its receptor: a novel therapeutic target Br J Pharmacol 129 1261 1283
4. W. Bryant J. Janik M. Baumann P. Callahan 1998 Orphanin FQ stimulates prolactin and growth hormone secretion in male and female rats Brain Res 807 228 233
5. M. Chesterfield J. Janik E. Murphree C. Lynn E. Schmidt P. Callahan 2006 Orphanin FQ/nociceptin is a physiological regulator of prolactin secretion in female rats Endocrinology 147 5087 5093
6. K.M. Dhandapani D.W. Brann 2002 Orphanin FQ inhibits GnRH secretion from rat hypothalamic fragments but not GT1-7 neurons Neuroreport 13 1247 1249
7. A.E. Herbison 1998 Multimodal influence of estrogen upon gonadotropin releasing hormone Endocr Rev 19 302 330
8. C.D. Foradori M. Amstalden L.M. Coolen S.R. Singh C.J. McManus R.J. Handa 2007 Orphanin FQ: evidence for a role in the control of the reproductive neuroendocrine system Endocrinology 148 4993 5001
9. X.F. An H.P. Chen S.L. Ma Y. Feng J.W. Hao B.Y. Chen 2005 Invovlement of nociceptin/orphanin FQ in release of hypothalamic GnRH mediated by ORL1 receptor in ovariectomized rats Acta Pharmacol Sin 26 1039 1044
10. M.J. Smith L. Jennes 2001 Neural signals that regulate GnRH neurones directly during the oestrous cycle Reproduction 122 1 10
11. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Academic Press, New York, 1998.
12. X. Chen D.B. McClatchy E.B. Geller L. Liu-Chen R.J. Tallarida M.W. Adler 2001 Possible mechanism of hypothermia induced by intracerebroventricular injection of orphanin FQ/nociceptin Brain Res 904 252 258
13. P.K. Olszewski A.S. Levine 2004 Characterization of influence of central nociceptin/orphanin FQ on consummatory behavior Endocrinology 145 2627 2632
14. K. Sinchak P. Dewing M. Cook P. Micevych 2007 Release of orphanin FQ/nociceptin in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus facilitates lordosis Horm Behav 51 406 412
15. C.R. Neal A. Mansour R. Reinscheid H.P. Nothacker O. Civelli H. Akil 1999 Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: comparison of ORL1 receptor mRNA expression with (125)I-[(14)Tyr]- orphanin FQ binding J Comp Neurol 412 563 605
16. C.R. Neal A. Mansour R. Reinscheid H.P. Nothacker O. Civelli S.J. Watson 1999 Localization of orphanin FQ (nociceptin) peptideand messenger RNA in the central nervous system J Comp Neurol 406 503 547
17. K. Sinchak H.E. Romeo P.E. Micevych 2006 Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system J Comp Neurol 496 252 268
18. E. Schlicker M. Morari 2000 Nociceptin/orphanin FQ and neurotransmitter release in the central nervous system Peptides 21 1023 1029
19. L. Jennes W. Lin S. Lakhlani 2002 Glutamatergic regulation of gonadotropin-releasing hormone neurons Prog Brain Res 141 183 192
20. X.F. An J.Y. Yu Y. Feng B.Y. Chen S.L. Zhang 2007 Role of hypothalamus nociceptin/orphanin FQ in pre-ovulatory luteinizing hormone surge of estrogen and progesterone-primed, ovariectomized rats Acta Pharmacol Sin 28 3028 3035