Long-term comparison of sublingual immunotherapy vs inhaled budesonide in patients with mild persistent asthma due to grass pollen

Annals of Allergy, Asthma and Immunology

Volumn 102, Issue 1, 2009, Pages 69-75

  Marogna, Maurizio ^a   Spadolini, Igino ^b   Massolo, Alessandro ^c   Berra, Daniele ^d   Zanon, Pietro ^d   Chiodini, Elena ^d   Canonica, Giorgio Walter ^e   Passalacqua, Giovanni ^e,f  

^a OSPEDALE DI CIRCOLO   (Italy)

^b Anallergo SpA   (Italy)

^c UNIVERSITY OF CALABRIA   (Italy)

^d BUSTO ARSIZIO HOSPITAL   (Italy)

^e UNIVERSITY OF GENOA   (Italy)

^f Allergy and Respiratory Diseases   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; CETIRIZINE; GRASS POLLEN ALLERGEN; IMMUNOMODULATING AGENT; POLLEN ANTIGEN; SALBUTAMOL; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ADOLESCENT; ADULT; ALLERGIC ASTHMA; ARTICLE; BRONCHUS HYPERREACTIVITY; CHEST TIGHTNESS; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOSTEROID THERAPY; COUGHING; DRUG EFFECT; DRUG EFFICACY; ENVIRONMENTAL EXPOSURE; EOSINOPHIL; FEMALE; GRASS POLLEN; HAY FEVER; HUMAN; IMMUNOTHERAPY; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MILD PERSISTENT ASTHMA; PATIENT COMPLIANCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SALVAGE THERAPY; SINGLE BLIND PROCEDURE; SUBLINGUAL IMMUNOTHERAPY; WHEEZING;

EID: 59449085560     PISSN: 10811206     EISSN: 15344436     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)60111-1     Document Type: Article

References (26)

1. Global Initiative for Asthma (GINA). Update 2006. www.ginasthma. org. Accessed August 2006.
2. Larchè M. Regulatory T cells in allergy and asthma. Chest. 2007;132: 1007-1014.
3. Jeffery PK. Remodelling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med. 2001;164(10, pt 2):S28.
4. Akdis M, Akdis C. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol. 2007;119(4):780-91.
5. Bousquet J, Van Cauwenberge P, Khaltaev N. Allergic rhinitis and its impact on asthma. ARIA: WHO Initiative. J Allergy Clin Immunol. 2001;108:S147-S334.
6. Passalacqua G, Durham SR. Allergic rhinitis and its impact on asthma update: allergen immunotherapy. J Allergy Clin Immunol. 2007;119(4): 881-91.
7. Durham SR, Walker SM, Varga EM, et al. Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med. 1999;341(7):468-75.
8. Ippoliti F, De Santis W, Volterrani A, et al. Immunomodulation during sublingual therapy in allergic children. Pediatr Allergy Immunol. 2003; 14(3):216-21.
9. Passalacqua G, Albano M, Fregonese L, et al. Randomised controlled trial of local allergoid immunotherapy on allergic inflammation in mite- induced rhinoconjunctivitis. Lancet. 1998;351(9103):629-32.
10. Ciprandi G, Fenoglio D, Cirillo I, et al. Induction of interleukin 10 by sublingual immunotherapy for house dust mites: a preliminary report. Ann Allergy Asthma Immunol. 2005;95(1):38 -44.
11. Puy R, Abramson A, Weiner JM. Allergen immunotherapy for asthma. Cochrane Database Syst Rev. 2003;(4):CD001186.
12. Penagos M, Passalacqua G, Compalati E, et al. Meta-analysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. Chest. 2008;133(3):599-609.
13. Grembiale RD, Camporota R, Djukanovic R, Marsico S. Effects of specific immunotherapy in allergic rhinitic individuals with bronchial hyperresponsiveness. Am J Respir Crit Care Med. 2000;162(6): 2048 -52.
14. Pajno GB, Passalacqua G, Vita D, Caminiti L, Parmiani S, Barberio G. Sublingual immunotherapy abrogates seasonal bronchial hyperrespon- siveness in children with Parietaria-induced respiratory allergy: a randomized controlled trial. Allergy. 2004;59(8):883-7.
15. Marogna M, Spadolini I, Massolo A, Canonica GW, Passalacqua G. Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: a 3-year randomized controlled study. J Allergy Clin Immunol. 2005;115(6):1184-8.
16. Sterk PJ, Fabbri LM, Quanjer PH, et al. Airway responsiveness standardized challenge testing with pharmacological, physical and sensitising stimuli in adults: report of the Working Party on Standardization of Lung Function Tests, European Coal and Steel Community. Official Statement of the European Respiratory Society. Eur Respir J. 1993; 16(suppl):53-83.
17. Ciprandi G, Ricca V, Landi M, Passalacqua G, Bagnasco M, Canonica GW. Allergen-specific nasal challenge: response kinetics of clinical and inflammatory events to rechallenge. Int Arch Allergy Immunol. 1998; 115:157-161.
18. Sokal, RR, Rohlf FJ. Biometry. The Principles and Practice of Statistics in Biological Research. 3rd ed. New York, NY: WH Freeman & Co; 1995.
19. Siegel, S, Castellan NJJ. Nonparametric Statistics for the Behavioral Sciences. New York, NY: McGraw-Hill; 1988.
20. Greenhouse SW, Geisser S. On methods in the analysis of profile data. Psychometrika, 1959;24(2):95-111.
21. Good P. Permutation Tests: A Practical Guide to Resampling Methods for Testing Hypotheses. 2nd Ed. New York, NY: Springer Verlag; 2000.
22. Moingeon P. Immune mechanisms of allergen-specific sublingual immunotherapy. Allergy. 2006;61(2):151-65.
23. Rak S, Heinrich C, Jacobsen L, Scheynius A, Venge P. A double- blinded, comparative study of the effects of short preseason specific immunotherapy and topical steroids in patients with allergic rhinocon- junctivitis and asthma. J Allergy Clin Immunol. 2001;108:921-928.
24. Pajno GB, Vita D, Parmiani S, Caminiti L, La Grutta S, Barberio G. Impact of sublingual immunotherapy on seasonal asthma and skin reactivity in children allergic to Parietaria pollen treated with inhaled fluticasone propionate. Clin Exp Allergy. 2003;33:1641-1647.
25. Shaikh WA. Immunotherapy vs inhaled budesonide in bronchial asthma: an open, parallel, comparative trial. Clin Exp Allergy. 1997;27:1279-1284.
26. Passalacqua G, Ciprandi G, Canonica GW. United airways disease: therapeutic aspects. Thorax. 2000;55(suppl 2):S26-S27.