NM23H2 inhibits EGF- and Ras-induced proliferation of NIH3T3 cells by blocking the ERK pathway

Cancer Letters

Volumn 275, Issue 2, 2009, Pages 221-226

  Lee, Mi Young ^a   Jeong, Woo Jeong ^a   Oh, Jong Won ^a   Choi, Kang Yell ^a  

^a Yonsei University   (South Korea)

Author keywords

ERK; Metastasis; NM23; NM23H2; Proliferation; Ras; Signal transduction; The Ras ERK pathway

Indexed keywords

EPIDERMAL GROWTH FACTOR; NUCLEOSIDE DIPHOSPHATE KINASE A; PROTEIN NM23H2; RAS PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STRAIN 3T3; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; DNA PRIMERS; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLOW CYTOMETRY; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; ONCOGENE PROTEIN P21(RAS);

EID: 59349106137     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.10.018     Document Type: Article

References (36)

1. Kimura N., Shimada N., Fukuda M., Ishijima Y., Miyazaki H., Ishii A., Takagi Y., and Ishikawa N. Regulation of cellular functions by nucleoside diphosphate kinases in mammals. J. Bioenerg. Biomembr. 32 (2000) 309-315
2. Ishikawa N., Shimada N., Takagi Y., Ishijima Y., Fukuda M., and Kimura N. Molecular evolution of nucleoside diphosphate kinase genes: conserved core structures and multiple-layered regulatory regions. J. Bioenerg. Biomembr. 35 (2003) 7-18
3. Lacombe M.L., Milon L., Munier A., Mehus J.G., and Lambeth D.O. The human Nm23/nucleoside diphosphate kinases. J. Bioenerg. Biomembr. 32 (2000) 247-258
4. Leone A., Flatow U., King C.R., Sandeen M.A., Margulies I.M., Liotta L.A., and Steeg P.S. Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell 65 (1991) 25-35
5. Leone A., Flatow U., VanHoutte K., and Steeg P.S. Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, Colonization and enzymatic activity. Oncogene 8 (1993) 2325-2333
6. Kauffman E.C., Robinson V.L., Stadler W.M., Sokoloff M.H., and Rinker-Schaeffer C.W. Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site. J. Urol. 169 (2003) 1122-1133
7. Ouatas T., Salerno M., Palmieri D., and Steeg P.S. Basic and translational advances in cancer metastasis: Nm23. J. Bioenerg. Biomembr. 35 (2003) 73-79
8. Postel E.H., Berberich S.J., Flint S.J., and Ferrone C.A. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. Science 261 (1993) 478-480
9. Rochdi M.D., Laroche G., Dupre E., Giguere P., Lebel A., Watier V., Hamelin E., Lepine M.C., Dupuis G., and Parent J.L. Nm23-H2 interacts with a G protein-coupled receptor to regulate its endocytosis through an Rac1-dependent mechanism. J. Biol. Chem. 279 (2004) 18981-18989
10. Fournier H.N., Dupe-Manet S., Bouvard D., Lacombe M.L., Marie C., Block M.R., and Albiges-Rizo C. Integrin cytoplasmic domain-associated protein 1alpha (ICAP-1alpha) interacts directly with the metastasis suppressor nm23-H2. And both proteins are targeted to newly formed cell adhesion sites upon integrin engagement. J. Biol. Chem. 277 (2002) 20895-20902
11. Lee W.J., Kim D.U., Lee M.Y., and Choi K.Y. Identification of proteins interacting with the catalytic subunit of PP2A by proteomics. Proteomics 7 (2007) 206-214
12. Adams D.G., Coffee Jr. R.L., Zhang H., Pelech S., Strack S., and Wadzinski B.E. Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes. J. Biol. Chem. 280 (2005) 42644-42654
13. Yu L.G., Packman L.C., Weldon M., Hamlett J., and Rhodes J.M. Protein phosphatase 2A, a negative regulator of the ERK signaling pathway, is activated by tyrosine phosphorylation of putative HLA class II-associated protein I (PHAPI)/pp32 in response to the antiproliferative lectin, jacalin. J. Biol. Chem. 279 (2004) 41377-41383
14. Roberts P.J., and Der C.J. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26 (2007) 3291-3310
15. Salerno M., Palmieri D., Bouadis A., Halverson D., and Steeg P.S. Nm23-H1 metastasis suppressor expression level influences the binding properties, stability, and function of the kinase suppressor of Ras1 (KSR1) Erk scaffold in breast carcinoma cells. Mol. Cell. Biol. 25 (2005) 1379-1388
16. Jeon S.H., Yoon J.Y., Park Y.N., Jeong W.J., Kim S., Jho E.H., Surh Y.J., and Choi K.Y. Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via beta-catenin. J. Biol. Chem. 282 (2007) 14482-14492
17. Cho S.J., Lee N.S., Jung Y.S., Lee H., Lee K.J., Kim E., and Chae S.K. Identification of structural domains affecting transactivation potential of Nm23. Biochem. Biophys. Res. Commun. 289 (2001) 738-743
18. Kim S.H., Kwon H.B., Kim Y.S., Ryu J.H., Kim K.S., Ahn Y., Lee W.J., and Choi K.Y. Isolation and characterization of a Drosophila homologue of mitogen-activated protein kinase phosphatase-3 which has a high substrate specificity towards extracellular-signal-regulated kinase. Biochem. J. 361 (2002) 143-151
19. Jeon S.H., Jeong W.J., Cho J.Y., Lee K.H., and Choi K.Y. Akt is involved in the inhibition of cell proliferation by EGF. Exp. Mol. Med. 39 (2007) 491-498
20. Park K.S., Ahn Y., Kim J.A., Yun M.S., Seong B.L., and Choi K.Y. Extracellular zinc stimulates ERK-dependent activation of p21(Cip/WAF1) and inhibits proliferation of colorectal cancer cells. Br. J. Pharmacol. 137 (2002) 597-607
21. Yun M.S., Kim S.E., Jeon S.H., Lee J.S., and Choi K.Y. Both ERK and Wnt/beta-catenin pathways are involved in Wnt3a-induced proliferation. J. Cell Sci. 118 (2005) 313-322
22. Lee J.H., Lee J.S., Kim S.E., Moon B.S., Kim Y.C., Lee S.K., and Choi K.Y. Tautomycetin inhibits growth of colorectal cancer cells through p21cip/WAF1 induction via the extracellular signal-regulated kinase pathway. Mol. Cancer Ther. 5 (2006) 3222-3231
23. Otero A.S. NM23/nucleoside diphosphate kinase and signal transduction. J. Bioenerg. Biomembr. 32 (2000) 269-275
24. Rosengard A.M., Krutzsch H.C., Shearn A., Biggs J.R., Barker E., Margulies I.M., King C.R., Liotta L.A., and Steeg P.S. Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development. Nature 342 (1989) 177-180
25. Steeg P.S., Bevilacqua G., Kopper L., Thorgeirsson U.P., Talmadge J.E., Liotta L.A., and Sobel M.E. Evidence for a novel gene associated with low tumor metastatic potential. J. Natl. Cancer Inst. 80 (1988) 200-204
26. Boissan M., Poupon M.F., and Lacombe M.L. NM23, metastasis suppressor genes Update. Med. Sci. (Paris) 23 (2007) 1115-1123
27. Horak C.E., Mendoza A., Vega-Valle E., Albaugh M., Graff-Cherry C., McDermott W.G., Hua E., Merino M.J., Steinberg S.M., Khanna C., and Steeg P.S. Nm23-H1 suppresses metastasis by inhibiting expression of the lysophosphatidic acid receptor EDG2. Cancer Res. 67 (2007) 11751-11759
28. Wang Y.F., Chen J.Y., Chang S.Y., Chiu J.H., Li W.Y., Chu P.Y., Tai S.K., and Wang L.S. Nm23-H1 expression of metastatic tumors in the lymph nodes is a prognostic indicator of oral squamous cell carcinoma. Int. J. Cancer 122 (2008) 377-386
29. Chang F., Steelman L.S., Shelton J.G., Lee J.T., Navolanic P.M., Blalock W.L., Franklin R., and McCubrey J.A. Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review). Int. J. Oncol. 22 (2003) 469-480
30. Thompson N., and Lyons J. Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery. Curr. Opin. Pharmacol. 5 (2005) 350-356
31. Gille H., Kortenjann M., Thomae O., Moomaw C., Slaughter C., Cobb M.H., and Shaw P.E. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J. 14 (1995) 951-962
32. Davis R.J. Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42 (1995) 459-467
33. Vetter I.R., and Wittinghofer A. The guanine nucleotide-binding switch in three dimensions. Science 294 (2001) 1299-1304
34. Park K.S., Jeon S.H., Kim S.E., Bahk Y.Y., Holmen S.L., Williams B.O., Chung K.C., Surh Y.J., and Choi K.Y. APC inhibits ERK pathway activation and cellular proliferation induced by RAS. J. Cell Sci. 119 (2006) 819-827
35. Kim S.E., and Choi K.Y. EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation. Cell Signal 19 (2007) 1554-1564
36. Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2 (2002) 489-501