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Volumn 33, Issue 8, 2008, Pages 649-654

BIBW-2992. Dual EGFR/HER2 inhibitor oncolytic

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 CHLORO 4 (2 PYRIDINYLMETHOXY)ANILINO] 3 CYANO 6 (4 DIMETHYLAMINOCROTONAMIDO) 7 ETHOXYQUINOLINE; ANGIOGENESIS INHIBITOR; BIBF 1120; BIBW 2992; CANERTINIB; CISPLATIN; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FLUOROURACIL; GEFITINIB; LAPATINIB; N [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 (TETRAHYDROFURAN 3 YLOXY)QUINAZOLIN 6 YL] 4 (DIMETHYLAMINO) 2 BUTENAMIDE; PACLITAXEL; PERTUZUMAB; PROTEIN TYROSINE KINASE INHIBITOR; TOVOK; TRASTUZUMAB; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR;

EID: 59349102970     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.2008.033.08.1237313     Document Type: Article
Times cited : (4)

References (36)
  • 1
    • 59349108656 scopus 로고    scopus 로고
    • Himmelsbach, F, Langkopf, E, Solca, F, Jung, B, Baum, A, Blech, S, Boehringer Ingelheim Pharma GmbH & Co, KG, Quinazoline derivatives, medicaments containing said compounds, their utilization and method for the production thereof. DE 10063435, EP 1345910, JP 2004516283, US 2002173509, US 2006100223, US 7019012, WO 0250043
    • Himmelsbach, F., Langkopf, E., Solca, F., Jung, B., Baum, A., Blech, S. (Boehringer Ingelheim Pharma GmbH & Co., KG). Quinazoline derivatives, medicaments containing said compounds, their utilization and method for the production thereof. DE 10063435, EP 1345910, JP 2004516283, US 2002173509, US 2006100223, US 7019012, WO 0250043.
  • 2
    • 59349105613 scopus 로고    scopus 로고
    • Soyka, R, Rall, W, Kulinna, C, Sieger, P, Schnaubelt, J, Boehringer Ingelheim Pharma GmbH & Co, KG, Process for preparing amino crotonyl compounds. DE 10349113, EP 1678165, JP 2007510624, US 2005085495, WO 2005037824
    • Soyka, R., Rall, W., Kulinna, C., Sieger, P., Schnaubelt, J. (Boehringer Ingelheim Pharma GmbH & Co., KG). Process for preparing amino crotonyl compounds. DE 10349113, EP 1678165, JP 2007510624, US 2005085495, WO 2005037824.
  • 3
    • 33846566408 scopus 로고    scopus 로고
    • Dual inhibition of ErbB1 (EGFR/HER1) and ErbB2 (HER2/neu)
    • Reid, A., Vidal, L., Shaw, H., de Bono, J. Dual inhibition of ErbB1 (EGFR/HER1) and ErbB2 (HER2/neu). Eur J Cancer 2007, 43(3): 481-9.
    • (2007) Eur J Cancer , vol.43 , Issue.3 , pp. 481-489
    • Reid, A.1    Vidal, L.2    Shaw, H.3    de Bono, J.4
  • 4
    • 17844372539 scopus 로고    scopus 로고
    • Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
    • Baselga, J., Arteaga, C. L. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 2005, 23(11): 2445-59.
    • (2005) J Clin Oncol , vol.23 , Issue.11 , pp. 2445-2459
    • Baselga, J.1    Arteaga, C.L.2
  • 5
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon, D.J., Clark, G.M., Wong, S.G., Levin, W.J., Ullrich, A., McGuire, W.L. Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 1987, 235(4785): 177-82.
    • (1987) Science , vol.235 , Issue.4785 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 6
    • 7444239715 scopus 로고    scopus 로고
    • Targeting ErbB receptor signalling: A pan-ErbB approach to cancer
    • Britten, C.D. Targeting ErbB receptor signalling: A pan-ErbB approach to cancer. Mol Cancer Ther 2004, 3(10): 1335-42.
    • (2004) Mol Cancer Ther , vol.3 , Issue.10 , pp. 1335-1342
    • Britten, C.D.1
  • 7
    • 44649167010 scopus 로고    scopus 로고
    • Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
    • Riely, G.J. Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. J Thorac Oncol 2008, 3(6, Suppl. 2): S146-9.
    • (2008) J Thorac Oncol , vol.3 , Issue.6 and SUPPL. 2
    • Riely, G.J.1
  • 8
    • 0033372557 scopus 로고    scopus 로고
    • Combination of EGFR, HER-2/ neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members
    • Xia, W., Lau, Y.-K., Zhang, H.-Z. et al. Combination of EGFR, HER-2/ neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members. Clin Cancer Res 1999, 5(12): 4164-74.
    • (1999) Clin Cancer Res , vol.5 , Issue.12 , pp. 4164-4174
    • Xia, W.1    Lau, Y.-K.2    Zhang, H.-Z.3
  • 10
    • 59349098385 scopus 로고    scopus 로고
    • Use of BIBW 2992, a novel irreversible EGFR/HER2 TKI, to induce regression in patients with adenocarcinoma of the lung and activating EGFR mutations: Preliminary results of a single-arm phase II clinical trial
    • Abst 8026
    • Yang, C., Shih, J., Chao, T. et al. Use of BIBW 2992, a novel irreversible EGFR/HER2 TKI, to induce regression in patients with adenocarcinoma of the lung and activating EGFR mutations: Preliminary results of a single-arm phase II clinical trial. J Clin Oncol [44th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(20, Suppl.): Abst 8026.
    • J Clin Oncol [44th Annu Meet Am Soc Clin Oncol (ASCO) (May 30-June 3, Chicago) 2008] 2008, 26(20, Suppl.)
    • Yang, C.1    Shih, J.2    Chao, T.3
  • 13
    • 77955092540 scopus 로고    scopus 로고
    • Efficacy of BIBW-2992, a potent irreversible inhibitor of EGFR and HER2 in human NSCLC xenografts in a transgenic mouse lung-cancer model
    • Sept 2-6, Seoul, Abst C7-04
    • Shimamura, T., Greulich, H., Solca, F.F., Wong, K.-K. Efficacy of BIBW-2992, a potent irreversible inhibitor of EGFR and HER2 in human NSCLC xenografts in a transgenic mouse lung-cancer model. J Thorac Oncol [12th World Conf Lung Cancer (Sept 2-6, Seoul) 2007] 2007, 2(8, Suppl. 4): Abst C7-04.
    • (2007) J Thorac Oncol [12th World Conf Lung Cancer , vol.2 , Issue.8 SUPPL. 4
    • Shimamura, T.1    Greulich, H.2    Solca, F.F.3    Wong, K.-K.4
  • 14
    • 84881481987 scopus 로고    scopus 로고
    • Efficacy of BIBW 2992, a potent irreversible inhibitor of EGFR and HER2, in models of head and neck cancer
    • Abst 5508
    • Solca, F., Baum, A., Krause, M., Baumann, M., Wong, K.K., Greulich, H., Adolf, G. Efficacy of BIBW 2992, a potent irreversible inhibitor of EGFR and HER2, in models of head and neck cancer. Eur J Cancer Suppl 2007, 54(4): Abst 5508.
    • (2007) Eur J Cancer Suppl , vol.54 , Issue.4
    • Solca, F.1    Baum, A.2    Krause, M.3    Baumann, M.4    Wong, K.K.5    Greulich, H.6    Adolf, G.7
  • 15
    • 34248144881 scopus 로고    scopus 로고
    • Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma
    • Schütze, C., Dörfler, A., Eicheler, W. et al. Combination of EGFR/HER2 tyrosine kinase inhibition by BIBW 2992 and BIBW 2669 with irradiation in FaDu human squamous cell carcinoma. Strahlenther Onkol 2007, 183(5): 256-64.
    • (2007) Strahlenther Onkol , vol.183 , Issue.5 , pp. 256-264
    • Schütze, C.1    Dörfler, A.2    Eicheler, W.3
  • 16
    • 84874079908 scopus 로고    scopus 로고
    • Efficacy of BIBW 2992, an irreversible dual EGFR/HER2 inhibitor, in combination with cytotoxic agents
    • Abst 567
    • Solca, F., Baum, A., Himmelsbach, F., Amelsberg, A., Adolf, G. Efficacy of BIBW 2992, an irreversible dual EGFR/HER2 inhibitor, in combination with cytotoxic agents. Eur J Cancer - Suppl 2006, 4(12): Abst 567.
    • (2006) Eur J Cancer - Suppl , vol.4 , Issue.12
    • Solca, F.1    Baum, A.2    Himmelsbach, F.3    Amelsberg, A.4    Adolf, G.5
  • 18
    • 59349084976 scopus 로고    scopus 로고
    • Pharmacokinetic results from two phase I dose escalation studies of once daily oral treatment with BIBW 2992, an irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in patients with advanced solid tumours
    • Nov 14-16, Philadelphia, Abst B172
    • Stopfer, P., Schaefer, H.G., Amelsberg, A. et al. Pharmacokinetic results from two phase I dose escalation studies of once daily oral treatment with BIBW 2992, an irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in patients with advanced solid tumours. 17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther (Nov 14-16, Philadelphia) 2005, Abst B172.
    • (2005) 17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther
    • Stopfer, P.1    Schaefer, H.G.2    Amelsberg, A.3
  • 20
    • 38049038935 scopus 로고    scopus 로고
    • A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours
    • Eskens, F.A., Mom, C.H., Planting, A.S. et al. A phase I dose escalation study of BIBW 2992, an irreversible dual inhibitor of epidermal growth factor receptor 1 (EGFR) and 2 (HER2) tyrosine kinase in a 2-week on, 2-week off schedule in patients with advanced solid tumours. Br J Cancer 2008, 98(1): 80-5.
    • (2008) Br J Cancer , vol.98 , Issue.1 , pp. 80-85
    • Eskens, F.A.1    Mom, C.H.2    Planting, A.S.3
  • 21
    • 59349115224 scopus 로고    scopus 로고
    • A phase I dose escalation study of BIBW 2992, an irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in patients with advanced solid tumours
    • ASCO, June 3-6, Atlanta, Abst 3091
    • Lewis, N., Marshall, J., Amelsberg, A., Cohen, R.B., Stopfer, P., Hwang J., Malik, S. A phase I dose escalation study of BIBW 2992, an irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in patients with advanced solid tumours, 42nd Annu Meet Am Soc Clin Oncol (ASCO) (June 3-6, Atlanta) 2006, Abst 3091.
    • (2006) 42nd Annu Meet Am Soc Clin Oncol
    • Lewis, N.1    Marshall, J.2    Amelsberg, A.3    Cohen, R.B.4    Stopfer, P.5    Hwang, J.6    Malik, S.7
  • 22
    • 79953651092 scopus 로고    scopus 로고
    • A phase I dose escalation study of BIBW 2992, an irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in a 3 week on 1 week off schedule in patients with advanced solid tumours
    • Nov 14-18, Philadelphia, Abst B161
    • Marshall, J., Lewis, N.L., Amelsberg, A., Briscoe, J., Hwang, J., Malik, S., Cohen, R. A phase I dose escalation study of BIBW 2992, an irreversible dual EGFR/HER2 receptor tyrosine kinase inhibitor, in a 3 week on 1 week off schedule in patients with advanced solid tumours. 17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther (Nov 14-18, Philadelphia) 2005, Abst B161.
    • (2005) 17th AACR-NCI-EORTC Int Conf Mol Targets Cancer Ther
    • Marshall, J.1    Lewis, N.L.2    Amelsberg, A.3    Briscoe, J.4    Hwang, J.5    Malik, S.6    Cohen, R.7
  • 23
    • 59349084242 scopus 로고    scopus 로고
    • A phase 1 dose escalation study of BIBW 2992, an irreversible dual EGFR/ HER2 receptor tyrosine kinase inhibitor, in a continuous schedule in patients with advanced solid tumours
    • ASCO, June 3-6, Atlanta, Abst 2074
    • Agus, D.B., Terlizzi, E., Stopfer, P., Amelsberg, A., Gordon, M.S. A phase 1 dose escalation study of BIBW 2992, an irreversible dual EGFR/ HER2 receptor tyrosine kinase inhibitor, in a continuous schedule in patients with advanced solid tumours. 42nd Annu Meet Am Soc Clin Oncol (ASCO) (June 3-6, Atlanta) 2006, Abst 2074.
    • (2006) 42nd Annu Meet Am Soc Clin Oncol
    • Agus, D.B.1    Terlizzi, E.2    Stopfer, P.3    Amelsberg, A.4    Gordon, M.S.5
  • 25
    • 59349087963 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic (PK) study of BIBW 2992, an oral irreversible dual EGFR/ HER2 inhibitor
    • Abst 703
    • Plummer, R., Vidal, L., Perrett, R. et al. A phase I and pharmacokinetic (PK) study of BIBW 2992, an oral irreversible dual EGFR/ HER2 inhibitor. Eur J Cancer - Suppl 2007, 5(4): Abst 703.
    • (2007) Eur J Cancer - Suppl , vol.5 , Issue.4
    • Plummer, R.1    Vidal, L.2    Perrett, R.3
  • 26
    • 39849089054 scopus 로고    scopus 로고
    • Activity of BIBW2992, an oral irreversible dual EGFR/HER2 inhibitor, in non-small cell lung cancer (NSCLC) with mutated EGFR
    • Abst D7-02
    • Spicer, J., Calvert, H., Vidal, L. et al. Activity of BIBW2992, an oral irreversible dual EGFR/HER2 inhibitor, in non-small cell lung cancer (NSCLC) with mutated EGFR. J Thorac Oncol 2007, 2(8, Suppl. 4): Abst D7-02.
    • (2007) J Thorac Oncol , vol.2 , Issue.8 and SUPPL. 4
    • Spicer, J.1    Calvert, H.2    Vidal, L.3
  • 32
    • 59349118069 scopus 로고    scopus 로고
    • Study to determine the maximum tolerated dose of BIBW 2992 (TOVOK) when combined with cisplatin/paclitaxel or cisplatin/5-FU in patients with advanced solid tumours (NCT00716417). ClinicalTrials.gov Web site, July 28, 2008.
    • Study to determine the maximum tolerated dose of BIBW 2992 (TOVOK) when combined with cisplatin/paclitaxel or cisplatin/5-FU in patients with advanced solid tumours (NCT00716417). ClinicalTrials.gov Web site, July 28, 2008.
  • 34
    • 59349119067 scopus 로고    scopus 로고
    • Phase I/II open label trial of continuous once daily oral treatment with BIBW 2992 - Phase I trial in advanced non small cell lung cancer patients & phase II trial in non small cell lung cancer patients failing erlotinib or gefitinib (NCT00711594). ClinicalTrials.gov Web site, July 28, 2008.
    • Phase I/II open label trial of continuous once daily oral treatment with BIBW 2992 - Phase I trial in advanced non small cell lung cancer patients & phase II trial in non small cell lung cancer patients failing erlotinib or gefitinib (NCT00711594). ClinicalTrials.gov Web site, July 28, 2008.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.