Childhood sexual abuse, selective attention for sexual cues and the effects of testosterone with or without vardenafil on physiological sexual arousal in women with sexual dysfunction: A pilot study

Journal of Sexual Medicine

Volumn 6, Issue 2, 2009, Pages 429-439

  van der Made, Flip ^a,b   Bloemers, Jos ^b   van Ham, Diana ^b   El Yassem, Wadi ^b   Kleiverda, Gunilla ^a   Everaerd, Walter ^c   Olivier, Berend ^d,e,f   Tuiten, Adriaan ^a,b,d  

^a Flevoziekenhuis   (Netherlands)

^b Emotional Brain Inc   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^f YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Female sexual dysfunction; Selective attention; Sexual abuse; Testosteroneand vardenafil; Vaginal pulse amplitude

Indexed keywords

CYCLODEXTRIN; PLACEBO; TESTOSTERONE; VARDENAFIL;

ADULT; ARTICLE; ASSOCIATION; CHILD SEXUAL ABUSE; CLINICAL ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONSCIOUSNESS LEVEL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EMOTION; FEMALE; FEMALE HYPOACTIVE SEXUAL DESIRE DISORDER; FEMALE SEXUAL DYSFUNCTION; HUMAN; MONOTHERAPY; PILOT STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SELECTIVE ATTENTION; SEXUAL AROUSAL; SEXUAL BEHAVIOR; TASK PERFORMANCE;

EID: 59349098816     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2008.01103.x     Document Type: Article

References (30)

1. Tuiten A, Van Honk J, Koppeschaar H, Bernaards C, Thijssen J, Verbaten R. Time course of effects of testosterone administration on sexual arousal in women. Arch Gen Psychiatry 2000;57:136.
2. Tuiten A, van Honk J, Verbaten R, Laan E, Everaerd W, Stam H. Can sublingual testosterone increase subjective and physiological measures of laboratory-induced sexual arousal? Arch Gen Psychiatry 2002;59:465-6.
3. Potempa AJ, Bernard I, Ulbrich E. Under flexible dosing, "real world"condition vardenafil improved erectile function in a broad population of men. Eur Urol Suppl 2003;2:96.
4. Markou S, Perimenis P, Gyftopoulos K, Athanasopoulos A, Barbalias G. Vardenafil (Levitra) for erectile dysfunction: A systematic review and meta-analysis of clinical trial reports. Int J Impot Res 2004;16:470-8.
5. Klotz T, Sachse R, Heidrich A, Jockenhövel F, Rohde G, Wensing G, Horstmann R, Engelmann R. Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: A RigiScan and pharmacokinetic study. World J Urol 2001;19:32-9.
6. Caruso S, Intelisano G, Farina M, Di Mari L, Agnello C. The function of sildenafil on female sexual pathways: A double-blind, cross-over, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol 2003;110:201-6.
7. Basson R, McInnes R, Smith MD, Hodgson G, Koppiker N. Efficacy and safety of sildenafil citrate in women with sexual dysfunction associated with female sexual arousal disorder. J Womens Health Gend Based Med 2002;11:367-77.
8. Shields KM, Hrometz SL. Use of sildenafil for female sexual dysfunction. Ann Pharmacother 2006;40:931-4.
9. Berman JR, Berman LA, Toler SM, Gill J, Haughie S; Sildenafil Study Group. Safety and efficacy of sildenafil citrate for the treatment of female sexual arousal disorder: A double-blind, placebo controlled study. J Urol 2003;170:2333-8.
10. Williams JM, Mathews A, MacLeod C. The emotional Stroop task and psychopathology. Psychol Bull 1996;120:3-10.
11. van Honk J, Tuiten A, van den Hout M, Putman P, de Haan E, Stam H. Selective attention to unmasked and masked threatening words: Relationships to trait anger and anxiety. Pers Individ Dif 2001;30:711-20.
12. Heard-Davison A, Heiman JR, Kuffel S. Genital and subjective measurement of the time course effects of an acute dose of testosterone vs. placebo in postmenopausal women. J Sex Med 2007;4:209-17.
13. van Honk J, Schutter DJ, Hermans EJ, Putman P, Tuiten A, Koppeschaar H. Testosterone shifts the balance between sensitivity for punishment and reward in healthy young women. Psychoneuroendocrinology 2004;29:937-43.
14. van Honk J, Tuiten A, Hermans E, Putman P, Koppeschaar H, Thijssen J, Verbaten R, van Doornen L. A single administration of testosterone induces cardiac accelerative responses to angry faces in healthy young women. Behav Neurosci 2001;115:238-42.
15. Postma A, Meyer G, Tuiten A, van Honk J, Kessels RP, Thijssen J. Effects of testosterone administration on selective aspects of object-location memory in healthy young women. Psychoneuroendocrinology 2000;25:563-75.
16. Aleman A, Bronk E, Kessels RP, Koppeschaar HP, van Honk J. A single administration of testosterone improves visuospatial ability in young women. Psychoneuroendocrinology 2004;29:612-17.
17. van Honk J, Peper JS, Schutter DJ. Testosterone reduces unconscious fear but not consciously experienced anxiety: Implications for the disorders of fear and anxiety. Biol Psychiatry 2005;58:218-25.
18. van Honk J, Schutter DJ. Testosterone reduces conscious detection of signals serving social correction: Implications for antisocial behavior. Psychol Sci 2007;18:663-7.
19. Hermans EJ, Putman P, van Honk J. Testosterone administration reduces empathetic behavior: A facial mimicry study. Psychoneuroendocrinology 2006;31:859-6.
20. Van Honk J, Schutter D. Decoupling of midfrontal delta-beta oscillations after testosterone administration. Int J Psychophysiol 2004;53:71-3.
21. Bancroft J, Janssen E. The dual control model of male sexual response: A theoretical approach to centrally mediated erectile dysfunction. Neurosci Biobehav Rev 2000;10:571-9.
22. Janssen E, Bancroft J. The dual control model: The role of sexual inhibition and excitation in sexual arousal and behaviour. In: Jansen E, ed. The psychophysiology of sex. Bloomington: Indiana University Press; 2007:197-222.
23. Alexander GM, Sherwin BB. Sex steroids, sexual behavior, and selection attention for erotic stimuli in women using oral contraceptives. Psychoneuroendocrinology 1993;18:91-102.
24. Rosen R, Brown C, Heiman J, Leiblum S, Meston C, Shabsigh R, Ferguson D, D'Agostino R Jr. The Female Sexual Function Index (FSFI): A multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 2000;26:191-208.
25. American Psychiatric Association. DSM-IV-TR: Diagnostic and statistical manual for mental disorders. 4th edition. Washington, DC: American Psychiatric Association; 2000.
26. Laan E, Everaerd W, Evers A. Assessment of female sexual arousal: Response specificity and construct validity. Psychophysiology 1995;32:476-85.
27. Tabachnick BG, Fidell LS. Profile analysis. In: Tabachnick BG, Fidell LS, eds. Using multivariate statistics. 5th edition. Boston, MA: Pearson Education, Inc.; 2006:345.
28. van Honk J, Tuiten A, van den Hout M, Koppeschaar H, Thijssen J, de Haan E, Verbaten R. Conscious and preconscious selective attention to social treat: Different neuroendocriene response patterns. Psychoneuroendocrinology 2001;25:577-91.
29. Rellini A. Review of the empirical evidence for a theoretical model to understand the sexual problems of women with a history of CSA. J Sex Med 2008;5:31-46.
30. Rellini A. Review of the empirical evidence for a theoretical model to understand the sexual problems of women with a history of CSA. J Sex Med 2008;5:31-46.