Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hs-CRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease

Diabetes Research and Clinical Practice

Volumn 83, Issue 3, 2009, Pages 308-315

  Katagiri, S ^a   Nitta, H ^a   Nagasawa, T ^a   Uchimura, I ^a   Izumiyama, H ^a   Inagaki, K ^b   Kikuchi, T ^b   Noguchi, T ^b   Kanazawa, M ^c   Matsuo, A ^c   Chiba, H ^c   Nakamura, N ^d   Kanamura, N ^d   Inoue, S ^e   Ishikawa, I ^f   Izumi, Y ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b AICHI GAKUIN UNIVERSITY   (Japan)

^c TOKYO MEDICAL UNIVERSITY   (Japan)

^d KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^e KYORITSU WOMEN'S UNIVERSITY   (Japan)

^f TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

C reactive protein; Diabetes mellitus; HbA1c; Insulin resistance; Periodontal disease

Indexed keywords

C REACTIVE PROTEIN; GLYCOSYLATED HEMOGLOBIN; MINOCYCLINE; PERIOFIL; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GLYCEMIC CONTROL; HUMAN; MALE; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIODONTAL DISEASE; PROTEIN BLOOD LEVEL; SENSITIVITY ANALYSIS;

ADULT; AGED; ANTI-INFECTIVE AGENTS; C-REACTIVE PROTEIN; DENTITION; DIABETES MELLITUS, TYPE 2; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MIDDLE AGED; PERIODONTAL DISEASES; TREATMENT OUTCOME;

EID: 59349090776     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2008.10.016     Document Type: Article

References (34)

1. Page R.C., Offenbacher S., Schroeder H.E., Seymour G.J., and Kornman K.S. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontology 2000 14 (1997) 216-248
2. Pihlstrom B.L., Michalowicz B.S., and Johnson N.W. Periodontal diseases. Lancet 366 (2005) 1809-1820
3. Mealey B.L., and Oates T.W. Diabetes mellitus and periodontal diseases. J. Periodontol. 77 (2006) 1289-1303
4. Tsai C., Hayes C., and Taylor G.W. Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population. Community Dent. Oral Epidemiol. 30 (2002) 182-192
5. Taylor G.W., Burt B.A., Becker M.P., Genco J., Shlossman M., Knowler W.C., et al. Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. J. Periodontol. 67 (1996) 1085-1093
6. Kiran M., Arpak N., Unsal E., and Erdogan M.F. The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus. J. Clin. Periodontol. 32 (2005) 266-272
7. Stewart J.E., Wager K.A., Friedlander A.H., and Zadeh H.H. The effect of periodontal treatment on glycemic control in patients with type 2 diabetes mellitus. J. Clin. Periodontol. 28 (2001) 306-310
8. Grossi S.G., Skrepcinski F.B., DeCaro T., Robertson D.C., Ho A.W., Dunford R.G., et al. Treatment of periodontal disease in diabetics reduces glycated hemoglobin. J. Periodontol. 68 (1997) 713-719
9. Iwamoto Y., Nishimura F., Nakagawa M., Sugimoto H., Shikata K., Makino H., et al. The effect of antimicrobial periodontal treatment on circulating tumor necrosis factor-alpha and glycated hemoglobin level in patients with type 2 diabetes. J. Periodontol. 72 (2001) 774-778
10. Christgau M., Palitzsch K.D., Schmalz G., Kreiner U., and Frenzel S. Healing response to non-surgical periodontal therapy in patients with diabetes mellitus: clinical, microbiological, and immunologic results. J. Clin. Periodontol. 25 (1998) 112-124
11. Festa A., D'Agostino Jr. R., Howard G., Mykkanen L., Tracy R.P., and Haffner S.M. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102 (2000) 42-47
12. Matsumoto K., Sera Y., Abe Y., Ueki Y., Tominaga T., and Miyake S. Inflammation and insulin resistance are independently related to all-cause of death and cardiovascular events in Japanese patients with type 2 diabetes mellitus. Atherosclerosis 169 (2003) 317-321
13. Pradhan A.D., Manson J.E., Rifai N., Buring J.E., and Ridker P.M. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286 (2001) 327-334
14. Slade G.D., Offenbacher S., Beck J.D., Heiss G., and Pankow J.S. Acute-phase inflammatory response to periodontal disease in the US population. J. Dent. Res. 79 (2000) 49-57
15. Wu T., Trevisan M., Genco R.J., Falkner K.L., Dorn J.P., and Sempos C.T. Examination of the relation between periodontal health status and cardiovascular risk factors: serum total and high density lipoprotein cholesterol, C-reactive protein, and plasma fibrinogen. Am. J. Epidemiol. 151 (2000) 273-282
16. Loos B.G., Craandijk J., Hoek F.J., Wertheim-van Dillen P.M., and van der Velden U. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J. Periodontol. 71 (2000) 1528-1534
17. Noack B., Genco R.J., Trevisan M., Grossi S., Zambon J.J., and De Nardin E. Periodontal infections contribute to elevated systemic C-reactive protein level. J. Periodontol. 72 (2001) 1221-1227
18. Glurich I., Grossi S., Albini B., Ho A., Shah R., Zeid M., et al. Systemic inflammation in cardiovascular and periodontal disease: comparative study. Clin. Diagn. Lab. Immunol. 9 (2002) 425-432
19. Ebersole J.L., Machen R.L., Steffen M.J., and Willmann D.E. Systemic acute-phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin. Exp. Immunol. 107 (1997) 347-352
20. Mattila K., Vesanen M., Valtonen V., Nieminen M., Palosuo T., and Rasi V. Effect of treating periodontitis on C-reactive protein levels: a pilot study. BMC Infect. Dis. 2 (2002) 30
21. D'Aiuto F., Nibali L., Parkar M., Suvan J., and Tonetti M.S. Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol. J. Dent. Res. 84 (2005) 269-273
22. Iwamoto Y., Nishimura F., Soga Y., Takeuchi K., Kurihara M., Takashiba S., et al. Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis. J. Periodontol. 74 (2003) 1231-1236
23. Nishimura F., Iwamoto Y., Mineshiba J., Shimizu A., Soga Y., and Murayama Y. Periodontal disease and diabetes mellitus: the role of tumor necrosis factor-alpha in a 2-way relationship. J. Periodontol. 74 (2003) 97-102
24. Yamazaki K., Honda T., Oda T., Ueki-Maruyama K., Nakajima T., Yoshie H., et al. Effect of periodontal treatment on the C-reactive protein and proinflammatory cytokine levels in Japanese periodontitis patients. J. Periodontal Res. 40 (2005) 53-58
25. Lalla E., Kaplan S., Yang J., Roth G.A., Papapanou P.N., and Greenberg S. Effects of periodontal therapy on serum C-reactive protein, sE-selectin, and tumor necrosis factor-alpha secretion by peripheral blood-derived macrophages in diabetes. A pilot study. J. Periodontal Res. 42 (2007) 274-282
26. Aldridge J.P., Lester V., Watts T.L., Collins A., Viberti G., and Wilson R.F. Single-blind studies of the effects of improved periodontal health on metabolic control in type 1 diabetes mellitus. J. Clin. Periodontol. 22 (1995) 271-275
27. Smith G.T., Greenbaum C.J., Johnson B.D., and Persson G.R. Short-term responses to periodontal therapy in insulin-dependent diabetic patients. J. Periodontol. 67 (1996) 794-802
28. Janket S.J., Wightman A., Baird A.E., Van Dyke T.E., and Jones J.A. Does periodontal treatment improve glycemic control in diabetic patients? A meta-analysis of intervention studies. J. Dent. Res. 84 (2005) 1154-1159
29. D'Aiuto F., Parkar M., Nibali L., Suvan J., Lessem J., and Tonetti M.S. Periodontal infections cause changes in traditional and novel cardiovascular risk factors: results from a randomized controlled clinical trial. Am. Heart J. 151 (2006) 977-984
30. Rodrigues D.C., Taba M.J., Novaes A.B., Souza S.L., and Grisi M.F. Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus. J. Periodontol. 74 (2003) 1361-1367
31. O'Connell P.A.A., Nomizo M.T., Freitas M.C.F., Suaid F.A., Uyemura S.A., Trevisan G.L., et al. Effects of periodontal therapy on glycemic control and inflammatory markers. J. Periodontol. 79 (2008) 774-783
32. Nesto R. C-reactive protein, its role in inflammation, Type 2 diabetes and cardiovascular disease, and the effects of insulin-sensitizing treatment with thiazolidinediones. Diabet. Med. 21 (2004) 810-817
33. Uysal K.T., Wiesbrock S.M., Marino M.W., and Hotamisligil G.S. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389 (1997) 610-614
34. Klover P.J., Zimmers T.A., Koniaris L.G., and Mooney R.A. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52 (2003) 2784-2789