Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation

Journal of Neuroscience Methods

Volumn 178, Issue 1, 2009, Pages 162-173

  Chen, Yu ^a,b   Aguirre, Aaron D ^a,c   Ruvinskaya, Lana ^d   Devor, Anna ^d,e   Boas, David A ^c,d   Fujimoto, James G ^a  

^a USA   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Depth resolved functional dynamics; Functional optical coherence tomography; Optical coherence tomography (OCT); Optical intrinsic signal imaging (OISI); Retrograde vessel dilation; Scattering change; Somatosensory cortex

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; FOREFOOT; HEMODYNAMICS; MALE; NEUROIMAGING; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; OPTICAL INTRINSIC SIGNAL IMAGING; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SOMATOSENSORY CORTEX; VASODILATATION;

ANIMALS; BRAIN; BRAIN MAPPING; ELECTRICAL SYNAPSES; FORELIMB; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; NONLINEAR DYNAMICS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 59249100596     PISSN: 01650270     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneumeth.2008.11.026     Document Type: Article

References (46)

1. Aguirre A.D., Chen Y., Fujimoto J.G., Ruvinskaya L., Devor A., and Boas D.A. Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography. Opt. Lett. 31 23 (2006) 3459-3461
2. Akkin T., Dave D.P., Milner T.E., and Rylander H.G. Detection of neural activity using phase-sensitive optical low-coherence reflectometry. Opt. Express 12 11 (2004) 2377-2386
3. Andrews P.M., Chen Y., Onozato M.L., Huang S.W., Adler D.C., Huber R.A., Jiang J., Barry S.E., Cable A.E., and Fujimoto J.G. High-resolution optical coherence tomography imaging of the living kidney. Lab. Invest. 88 4 (2008) 441-449
4. Bacskai B.J., Hickey G.A., Skoch J., Kajdasz S.T., Wang Y., Huang G.F., Mathis C.A., Klunk W.E., and Hyman B.T. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 100 21 (2003) 12462-12467
5. Bizheva K., Pflug R., Hermann B., Povazay B., Sattmann H., Qiu P., Anger E., Reitsamer H., Popov S., Taylor J.R., Unterhuber A., Ahnelt P., and Drexler W. Optophysiology: depth-resolved probing of retinal physiology with functional ultrahigh-resolution optical coherence tomography. Proc. Natl. Acad. Sci. U.S.A. 103 13 (2006) 5066-5071
6. Bourquin S., Aguirre A.D., Hartl I., Hsiung P., Ko T.H., Fujimoto J.G., Birks T.A., Wadsworth W.J., Bunting U., and Kopf D. Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd:Glass laser and nonlinear fiber. Opt. Express 11 24 (2003) 3290-3297
7. Chaigneau E., Oheim M., Audinat E., and Charpak S. Two-photon imaging of capillary blood flow in olfactory bulb glomeruli. Proc. Natl. Acad. Sci. U.S.A. 100 22 (2003) 13081-13086
8. Chen Z., Milner T.E., Srinivas S., Wang X., Malekafzali A., van Gemert M.J.C., and Nelson J.S. Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. Opt. Lett. 22 14 (1997) 1119-1121
9. Choma M.A., Sarunic M.V., Yang C.H., and Izatt J.A. Sensitivity advantage of swept source and Fourier domain optical coherence tomography. Opt. Express 11 18 (2003) 2183-2189
10. de Boer J.F., Cense B., Park B.H., Pierce M.C., Tearney G.J., and Bouma B.E. Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. Opt. Lett. 28 21 (2003) 2067-2069
11. Devor A., Dunn A.K., Andermann M.L., Ulbert I., Boas D.A., and Dale A.M. Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex. Neuron 39 2 (2003) 353-359
12. Devor A., Ulbert I., Dunn A.K., Narayanan S.N., Jones S.R., Andermann M.L., Boas D.A., and Dale A.M. Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity. Proc. Natl. Acad. Sci. U.S.A. 102 10 (2005) 3822-3827
13. Dunn A.K., Devor A., Dale A.M., and Boas D.A. Spatial extent of oxygen metabolism and hemodynamic changes during functional activation of the rat somatosensory cortex. Neuroimage 27 2 (2005) 279-290
14. Fang-Yen C., Chu M.C., Seung H.S., Dasari R.R., and Feld M.S. Noncontact measurement of nerve displacement during action potential with a dual-beam low-coherence interferometer. Opt. Lett. 29 17 (2004) 2028-2030
15. Franceschini M.A., Joseph D.K., Huppert T.J., Diamond S.G., and Boas D.A. Diffuse optical imaging of the whole head. J. Biomed. Opt. 11 5 (2006)
16. Frostig R.D., Lieke E.E., Tso D.Y., and Grinvald A. Cortical functional architecture and local coupling between neuronal-activity and the microcirculation revealed by in vivo high-resolution optical imaging of intrinsic signals. Proc. Natl. Acad. Sci. U.S.A. 87 16 (1990) 6082-6086
17. Girouard H., and Iadecola C. Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. J. Appl. Physiol. 100 1 (2006) 328-335
18. Gratton G., and Fabiani M. Shedding light on brain function: the event-related optical signal. Trends Cogn. Sci. 5 8 (2001) 357-363
19. Grinvald A., Frostig R.D., Lieke E., and Hildesheim R. Optical imaging of neuronal-activity. Physiol. Rev. 68 4 (1988) 1285-1366
20. Hillman E.M. Optical brain imaging in vivo: techniques and applications from animal to man. J. Biomed. Opt. 12 5 (2007) 051402
21. Hillman E.M., Devor A., Bouchard M.B., Dunn A.K., Krauss G.W., Skoch J., Bacskai B.J., Dale A.M., and Boas D.A. Depth-resolved optical imaging and microscopy of vascular compartment dynamics during somatosensory stimulation. Neuroimage 35 1 (2007) 89-104
22. Hillman E.M.C., Boas D.A., Dale A.M., and Dunn A.K. Laminar optical tomography: demonstration of millimeter-scale depth-resolved imaging in turbid media. Opt. Lett. 29 14 (2004) 1650-1652
23. Huang D., Swanson E.A., Lin C.P., Schuman J.S., Stinson W.G., Chang W., Hee M.R., Flotte T., Gregory K., Puliafito C.A., and Fujimoto J.G. Optical coherence tomography. Science 254 5035 (1991) 1178-1181
24. Iadecola C., Yang G., Ebner T.J., and Chen G. Local and propagated vascular responses evoked by focal synaptic activity in cerebellar cortex. J. Neurophysiol. 78 2 (1997) 651-659
25. Kleinfeld D., Mitra P.P., Helmchen F., and Denk W. Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. Proc. Natl. Acad. Sci. U.S.A. 95 26 (1998) 15741-15746
26. Lazebnik M., Marks D.L., Potgieter K., Gillette R., and Boppart S.A. Functional optical coherence tomography for detecting neural activity through scattering changes. Opt. Lett. 28 14 (2003) 1218-1220
27. Leitgeb R., Hitzenberger C.K., and Fercher A.F. Performance of Fourier domain vs. time domain optical coherence tomography. Opt. Express 11 8 (2003) 889-894
28. Maheswari R.U., Takaoka H., Homma R., Kadono H., and Tanifuji M. Implementation of optical coherence tomography (OCT) in visualization of functional structures of cat visual cortex. Opt. Commun. 202 1-3 (2002) 47-54
29. Maheswari R.U., Takaoka H., Kadono H., Homma R., and Tanifuji M. Novel functional imaging technique from brain surface with optical coherence tomography enabling visualization of depth resolved functional structure in vivo. J. Neurosci. Methods 124 1 (2003) 83-92
30. Malonek D., Dirnagl U., Lindauer U., Yamada K., Kanno I., and Grinvald A. Vascular imprints of neuronal activity: relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation. Proc. Natl. Acad. Sci. U.S.A. 94 26 (1997) 14826-14831
31. Ngai A.C., and Winn H.R. Pial arteriole dilation during somatosensory stimulation is not mediated by an increase in CSF metabolites. Am. J. Physiol. Heart Circ. Physiol. 282 3 (2002) H902-H907
32. Orbach H.S., Cohen L.B., and Grinvald A. Optical mapping of electrical-activity in rat somatosensory and visual-cortex. J. Neurosci. 5 7 (1985) 1886-1895
33. Rajagopalan U.M., and Tanifuji M. Functional optical coherence tomography reveals localized layer-specific activations in cat primary visual cortex in vivo. Opt. Lett. 32 17 (2007) 2614-2616
34. Rector D.M., Carter K.M., Volegov P.L., and George J.S. Spatio-temporal mapping of rat whisker barrels with fast scattered light signals. Neuroimage 26 2 (2005) 619-627
35. Rector D.M., Rogers R.F., Schwaber J.S., Harper R.M., and George J.S. Scattered-light imaging in vivo tracks fast and slow processes of neurophysiological activation. Neuroimage 14 5 (2001) 977-994
36. Satomura Y., Seki J., Ooi Y., Yanagida T., and Seiyama A. In vivo imaging of the rat cerebral microvessels with optical coherence tomography. Clin. Hemorheol. Microcirc. 31 1 (2004) 31-40
37. Schmitt J.M. Optical coherence tomography (OCT): a review. IEEE J. Selected Top. Quantum Electron. 5 4 (1999) 1205-1215
38. Sheth S.A., Nemoto M., Guiou M., Walker M., Pouratian N., and Toga A.W. Linear and nonlinear relationships between neuronal activity, oxygen metabolism, and hemodynamic responses. Neuron 42 2 (2004) 347-355
39. Sheth S.A., Nemoto M., Guiou M.W., Walker M.A., and Toga A.W. Spatiotemporal evolution of functional hemodynamic changes and their relationship to neuronal activity. J. Cereb. Blood Flow Metab. 25 7 (2005) 830-841
40. Srinivasan V.J., Wojtkowski M., Fujimoto J.G., and Duker J.S. In vivo measurement of retinal physiology with high-speed ultrahigh-resolution optical coherence tomography. Opt. Lett. 31 15 (2006) 2308-2310
41. Svoboda K., and Yasuda R. Principles of two-photon excitation microscopy and its applications to neuroscience. Neuron 50 6 (2006) 823-839
42. Tso D.Y., Frostig R.D., Lieke E.E., and Grinvald A. Functional-organization of primate visual-cortex revealed by high-resolution optical imaging. Science 249 4967 (1990) 417-420
43. Villringer A., and Chance B. Non-invasive optical spectroscopy and imaging of human brain function. Trends Neurosci. 20 10 (1997) 435-442
44. Wang R.K., Jacques S.L., Ma Z., Hurst S., Hanson S.R., and Gruber A. Three dimensional optical angiography. Opt. Express 15 7 (2007) 4083-4097
45. Wang R.K.K., and Hurst S. Mapping of cerebro-vascular blood perfusion in mice with skin and skull intact by Optical Micro-AngioGraphy at 1.3 μm wavelength. Opt. Express 15 18 (2007) 11402-11412
46. Yao X.-C., Yamauchi A., Perry B., and George J.S. Rapid optical coherence tomography and recording functional scattering changes from activated frog retina. Appl. Opt. 44 11 (2005) 2019-2023