Converging on the origins of axonal ion channel clustering

PLoS Genetics

Volumn 5, Issue 1, 2009, Pages

  Rasband, Matthew N ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; ION CHANNEL; POTASSIUM CHANNEL KCNQ2; PROTEIN ANKYRIN G; SODIUM CHANNEL; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BRAIN NERVE CELL; CLUSTER ANALYSIS; CONVERGENT EVOLUTION; NERVE FIBER; NONHUMAN; PHYLOGENY; PROTEIN PROTEIN INTERACTION; RANVIER NODE; REVIEW; ANIMAL; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; NOTE;

AMINO ACID SEQUENCE; ANIMALS; AXONS; EVOLUTION, MOLECULAR; HUMANS; ION CHANNELS; MOLECULAR SEQUENCE DATA; RANVIER'S NODES;

EID: 59249096079     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000340     Document Type: Review

References (16)

1. Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, et al. (2008) Action potential generation requires a high sodium channel density in the axon initial segment. Nat Neurosci 11: 178-186.
2. Schwarz JR, Glassmeier G, Cooper EC, Kao TC, Nodera H, et al. (2006) KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier. J Physiol 573: 17-34.
3. Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA (2008) Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A 105: 7869-7874.
4. Winckler B, Forscher P, Mellman I (1999) A diffusion barrier maintains distribution of membrane proteins in polarized neurons. Nature 397: 698-701.
5. Hedstrom KL, Ogawa Y, Rasband MN (2008) AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity. J Cell Biol 183: 635-640.
6. Hedstrom KL, Xu X, Ogawa Y, Frischknecht R, Seidenbecher CI, et al. (2007) Neurofascin assembles a specialized extracellular matrix at the axon initial segment. J Cell Biol 178: 875-886.
7. Zhou D, Lambert S, Malen PL, Carpenter S, Boland LM, et al. (1998) AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. J Cell Biol 143: 1295-1304.
8. Dzhashiashvili Y, Zhang Y, Galinska J, Lam I, Grumet M, et al. (2007) Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms. J Cell Biol 177: 857-870.
9. Garrido JJ, Giraud P, Carlier E, Fernandes F, Moussif A, et al. (2003) A targeting motif involved in sodium channel clustering at the axonal initial segment. Science 300: 2091-2094.
10. Lemaillet G, Walker B, Lambert S (2003) Identification of a conserved ankyrin-binding motif in the family of sodium channel alpha subunits. J Biol Chem 278: 27333-27339.
11. Pan Z, Kao T, Horvath Z, Lemos J, Sul J-Y, et al. (2006) A common ankyrin-G-based mechanism retains KCNQ and Nav channels at electrically active domains of the axon. J Neurosci 26: 2599-2613.
12. Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, et al. (2008) Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. PLoS Genet 4(12): e1000317. doi:10.1371/journal.pgen.1000317.
13. Teravainen H, Rvainen CM (1971) Fast and slow motorneurons to body muscle of the sea lamprey. J Neurophysiol 34: 990-998.
14. Susuki K, Rasband MN (2008) Molecular mechanisms of node of Ranvier formation. Curr Opin Cell Biol 20: 616-623.
15. Kordeli E, Lambert S, Bennett V (1995) AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. J Biol Chem 270: 2352-2359.
16. Bréchet A, Fache MP, Brachet A, Ferracci G, Baude A, et al. (2008) Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interaction with ankyrin G. J Cell Biol. E-pub ahead of print. doi:10.1083/jcb.200805169.