Fulminant hepatitis induced by lamotrigine

Southern Medical Journal

Volumn 102, Issue 1, 2009, Pages 82-84

  Ouellet, Georges ^a   Tremblay, Lydjie ^a   Marleau, Denis ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

Adverse drug reaction; Anticonvulsant hypersensitivity syndrome; Hepatitis; Lamotrigine

Indexed keywords

CEFOTAXIME; LACTULOSE; LAMOTRIGINE; METRONIDAZOLE; VITAMIN K GROUP; ANTICONVULSIVE AGENT; TRIAZINE DERIVATIVE;

ADULT; ARTICLE; ASTHENIA; BACTERIAL PERITONITIS; BIPOLAR DISORDER; CASE REPORT; DRESS SYNDROME; DRUG DOSE INCREASE; DRUG WITHDRAWAL; FEMALE; FEVER; FLU LIKE SYNDROME; FOLLOW UP; HEPATIC ENCEPHALOPATHY; HEPATITIS; HUMAN; HYPERTHERMIA; LABORATORY TEST; RASH; TREATMENT OUTCOME; LIVER FAILURE; REVIEW; TOXIC HEPATITIS; TOXICITY AND INTOXICATION;

ADULT; ANTICONVULSANTS; BIPOLAR DISORDER; FEMALE; HEPATITIS, TOXIC; HUMANS; LIVER FAILURE, ACUTE; NEUROTOXICITY SYNDROMES; TRIAZINES;

EID: 59249092556     PISSN: 00384348     EISSN: None     Source Type: Journal    
DOI: 10.1097/SMJ.0b013e3181878b95     Document Type: Article

References (9)

1. Malik S, Arif H, Hirsch LJ. Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. Expert Rev Neurother 2006;6:1609-1627.
2. Bohan KH, Mansuri TF, Wilson NM. Anticonvulsant hypersensitivity syndrome: implications for pharmaceutical care. Pharmacotherapy 2007; 27:1425-1439.
3. Schaub N, Bircher AJ. Severe hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro. Allergy 2000;55:191-193.
4. Schlienger RG, Knowles SR, Shear NH. Lamotrigine-associated anticon-vulsant hypersensitivity syndrome. Neurology 1998;51:1172-1175.
5. Makin AJ, Fitt S, Williams R, et al. Fulminant hepatic failure induced by lamotrigine. BMJ 1995;311:292.
6. Arnon R, DeVivo D, Defelice AR, et al. Acute hepatic failure in a child treated with lamotrigine. Pediatr Neurol 1998;18:251-252.
7. Veyrac G, Marcade G, Chiffoleau A, et al. Characteristics of hypersensitivity syndrome to lamotrigine: review of one case reported in the Regional Center of Pharmacovigilance of Nantes. Thérapie 2002;57:289-296.
8. Overstreet K, Costanza C, Behling C, et al. Fatal progressive hepatic necrosis associated with lamotrigine treatment: a case report and literature review. Dig Dis Sci 2002;47:1921-1925.
9. Mecarelli O, Pulitano P, Mingoia M, et al. Acute hepatitis associated with lamotrigine and managed with the molecular adsorbents recirculating system (MARS). Epilepsia 2005;46:1687-1689.