Immunomodulatory activity of a methionine aminopeptidase-2 inhibitor on B cell differentiation

Clinical and Experimental Immunology

Volumn 155, Issue 3, 2009, Pages 514-522

  Priest, R C ^a   Spaull, J ^a   Buckton, J ^a   Grimley, R L ^a   Sims, M ^a   Binks, M ^a   Malhotra, R ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

B cell differentiation; Germinal centre; Methionine aminopeptidase 2

Indexed keywords

[(1 CARAMOYL 2 METHYLPROPYL)]CARBAMIC ACID 5 METHOXY 4 2 METHYL 3 (3 METHYLBUT 2 ENYL)OXIRANYL] 1 OXASPIRO(2 5)OCT 6 YL ESTER]; ANTIBODY; B LYMPHOCYTE RECEPTOR; CD40 ANTIGEN; ENZYME INHIBITOR; INTERLEUKIN 21; METHIONYL AMINOPEPTIDASE 2; PPI 2458; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; IMMUNIZATION; IMMUNOMODULATION; MARMOSET; MOUSE; NONHUMAN; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; T LYMPHOCYTE;

AMINOPEPTIDASES; ANIMALS; ANTIBODIES; B-LYMPHOCYTES; CALLITHRIX; CELL DIFFERENTIATION; DEPRESSION, CHEMICAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPOXY COMPOUNDS; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE COUNT; METALLOENDOPEPTIDASES; MICE; MODELS, ANIMAL; SPECIES SPECIFICITY; SPLEEN; VALINE;

EID: 59249087041     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2008.03843.x     Document Type: Article

References (18)

1. Datta B, Majumdar A, Datta R, Balusu R. Treatment of cells with the angiogenic inhibitor fumagillin results in increased stability of eukaryotic initiation factor 2-associated glycoprotein, p67, and reduced phosphorylation of extracellular signal-regulated kinases. Biochemistry 2004 43 : 14821 31.
2. Datta B, Datta R, Ghosh A, Majumdar A. Eukaryotic initiation factor 2-associated glycoprotei n7 shows differential effects on the activity of certain kinases during serum starved conditions. Arch Biochem Biophys 2004 427 : 68 78.
3. Lowther WT, Matthews BW. Structure and function of the methionine aminopeptidases. Biochim Biophys Acta 2000 1477 : 157 67.
4. Kanno T, Endo H, Takeuchi K, Morishita Y, Fukayama M, Mori S. High expression of methionine aminopeptidase type 2 in germinal center B cells and their neoplastic counterparts. Lab Invest 2002 82 : 893 901.
5. Sin N, Meng L, Wang MQ, Wen JJ, Bornmann WG, Crews CM. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. Proc Natl Acad Sci USA 1997 94 : 6099 103.
6. Bradshaw RA, Brickey WW, Walker KW. N-terminal processing: the methionine 22 aminopeptidase an dN alpha-acetyl transferase families. Trends Biochem Sci 1998 23 : 263 7.
7. Turk BE, Su Z, Liu JO. Synthetic analogues of TNP-470 and ovalicin reveal a common molecular basis for inhibition of angiogenesis and immunosuppression. Bioorg Med Chem 1978 6 : 1163 9.
8. Griffith EC, Su Z, Turk BE et al. Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. Chem Biol 1997 4 : 461 71.
9. Ingber D, Fujita T, Kishimoto S et al. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth. Nature 1990 348 : 555 7.
10. Yamamoto T, Sudo K, Fujita T. Significant inhibition of endothelial cell growth in tumor vasculature by an angiogenesis inhibitor, TNP-470 (AGM-1470). Anticancer Res 1994 14 : 1 3.
11. Wohlleben G, Gray D, Schimpl A. In vitro immunization of naive mouse B cells: establishment of IgM secreting hybridomas specific for souble protein or hapten from B cells cultured on CD40 ligand transfected mouse fibroblasts. Int Immunol 1996 8 : 343 9.
12. Bernier SG, Lazarus DD, Clark E et al. A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis. Proc Natl Acad Sci USA 2004 101 : 10768 73.
13. Bernier SG, Taghizadeh N, Thompson CD, Westlin WF, Hannig G. Methionine aminopeptidases type I and type II are essential to control cell proliferation. J Cell Biochem 2005 95 : 1191 203.
14. Bainbridge J, Madden L, Essex D, Binks M, Malhotra R, Paleolog EM. Methionine aminopeptidase-2 blockade reduces chronic collagen-induced arthritis: potential role for angiogenesis inhibition. Arthritis Res Ther 2007 9 : R127.
15. Leonard WJ, Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol 2005 5 : 688 98.
16. Lazarus DD, Doyle EG, Bernier SG et al. An inhibitor of methionine aminopeptidase type-2, PPI-2458, ameliorates the pathophysiological disease processes of rheumatoid arthritis. Inflamm Res 2008 57 : 18 27.
17. Ozaki K, Spolski R, Feng CG et al. A critical role for IL-21 in regulating immunoglobulin production. Science 2002 298 : 1630 4.
18. Hartmann GR, Richter H, Weiner EM, Zimmermann W. On the mechanism of action of the cytostatic drug anguidine and of the immunosuppressive agent ovalicin, two sesquiterpenes from fungi. Planta Med 1978 34 : 231 52.