Transplantation of poly(N-isopropylacrylamide-co-vinylimidazole) hydrogel constructs composed of rabbit chondrocytes and growth factor-loaded nanoparticles for neocartilage formation

Biotechnology Letters

Volumn 31, Issue 3, 2009, Pages 337-346

  Park, Keun Hong ^a   Lee, Don Haeng ^b   Na, Kun ^c  

^a CHA University   (South Korea)

^b Inha University School of Medicine   (South Korea)

^c The Catholic University of Korea   (South Korea)

Author keywords

Cartilage tissue engineering; Chondrocytes; Poly(N isopropylacrylamide co vinylimidazole) p(NiPAAm co VI); Transforming growth factor 1

Indexed keywords

ACRYLIC MONOMERS; AMIDES; BIOACTIVITY; BODY FLUIDS; CARTILAGE; CELL GROWTH; FOURIER TRANSFORMS; GROWTH (MATERIALS); LIGAMENTS; NANOPARTICLES; NUCLEIC ACIDS; ORGANIC ACIDS; PEPTIDES; TISSUE ENGINEERING; VEGETATION;

CARTILAGE TISSUE ENGINEERING; CARTILAGE TISSUES; CELL PHENOTYPES; CHONDROCYTE; CHONDROCYTES; COMPOSITE HYDROGELS; DNA CONTENTS; GROWTH FACTORS; IMMUNOHISTOCHEMISTRY; IN CELLS; NEOCARTILAGE; POLY(N-ISOPROPYLACRYLAMIDE-CO-VINYLIMIDAZOLE) P(NIPAAM-CO-VI); PROTEIN ACTIVITIES; THERMOREVERSIBLE HYDROGELS;

HYDROGELS;

COLLAGEN; DNA; IMIDAZOLE DERIVATIVE; NANOPARTICLE; POLY(N ISOPROPYLACRYLAMIDE CO 1 VINYLIMIDAZOLE); POLY(N-ISOPROPYLACRYLAMIDE-CO-1-VINYLIMIDAZOLE); TRANSFORMING GROWTH FACTOR BETA; VINYL DERIVATIVE;

ANIMAL; ARTICLE; CARTILAGE CELL; CHEMISTRY; GENE EXPRESSION PROFILING; HYDROGEL; METHODOLOGY; RABBIT; TRANSPLANTATION;

ANIMALS; CHONDROCYTES; COLLAGEN; DNA; GENE EXPRESSION PROFILING; HYDROGEL; IMIDAZOLES; NANOPARTICLES; RABBITS; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION; VINYL COMPOUNDS;

ORYCTOLAGUS CUNICULUS;

EID: 59149103644     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-008-9871-6     Document Type: Article

References (19)

1. M Abe M Takahashi A Nagano 2005 The effect of hyaluronic acid with different molecular weights on collagen crosslink synthesis in cultured chondrocytes embedded in collagen gels J Biomed Mater Res A 75 494 499
2. A Au A Polotsky K Krzyminski A Gutowska DS Hungerford CG Frondoza 2004 Evaluation of thermoreversible polymers containing fibroblast growth factor 9 (FGF-9) for chondrocyte culture J Biomed Mater Res A 69 367 372
3. JP Fisher S Jo AG Mikos AH Reddi 2006 Thermoreversible hydrogel scaffolds for articular cartilage engineering J Biomed Mater Res A 71 268 274
4. TR Heide J Gernot 1999 In situ measurement of collagen synthesis by human bone cells with a Sirius red-based colorimetric microassay: effects of transforming growth factor beta-2 and ascorbic acid 2-phosphate Histochem Cell Biol 112 271 276
5. Y Hong C Gao Y Xie Y Gong J Shen 2005 Collagen-coated polylactide microspheres as chondrocyte microcarriers Biomaterials 26 6305 6313
6. SW Kang O Jeon BS Kim 2005 Poly(lactic-co-glycolic acid) microspheres as an injectable scaffold for cartilage tissue engineering Tissue Eng 11 438 447
7. TH Kim JE Ihm YJ Choi JW Nah CS Cho 2000 Development of fibrin derivatives for controlled release of heparin-binding growth factors J Control Release 65 389 402
8. K Na JH Park SW Kim DG Woo BK Sun HM Chung KH Park 2006 Delivery of dexamethasone, ascorbate, and growth factor (TGF β-3) in thermo-reversible hydrogel constructs embedded with rabbit chondrocytes Biomaterials 27 5951 5957
9. K Na SJ Choi S Kim BK Sun DG Woo HM Chung KH Park 2007 Enhancement of cell proliferation and differentiation by combination of ascorbate and dexamethasone in thermo-reversible hydrogel constructs embedded Biotechnol Lett 29 1453 1457
10. K Na S Kim K Park K Kim DG Woo IC Kwon HM Chung KH Park 2007 Heparin/poly(l-lusine) nanoparticle-coated polymeric microspheres for stem-cell therapy J Am Chem Soc 129 5788 5789
11. K Na S Kim BK Sun DG Woo HM Chung KH Park 2007 Blended construct consisting of thermo-reversible hydrogels and heparinized nanoparticles for increasing proliferation activity of rabbit condrocyte in vivo test Biotechnol Lett 29 1447 1452
12. K Na S Kim BK Sun DG Woo HM Chung KH Park 2007 Combination material delivery of dexamethasone and growth factor in hydrogel blended with hyaluronic acid constructs for neocartilage formation J Biomed Mater Res A 83A 779 786
13. KH Park K Na SW Kim SY Jung KH Park HM Chung 2005 Phenotype of hepatocyte spheroids behavior within thermo-sensitive poly(NiPAAm-co-PEG-g-GRGDS) hydrogel as a cell delivery vehicle Biotechnol Lett 27 1081 1086
14. P Roughley C Hoemann E DesRosiers F Mwale J Antoniou M Alini 2006 The potential of chitosan-based gels containing intervertebral disc cells for nucleus pulposus supplementation Biomaterials 27 388 396
15. GT Syftestad M Weitzhandler AI Caplan 1985 Isolation and characterization of osteogenic cells derived from first bone of the embryonic tibia Dev Biol 110 275 283
16. Sundaram M, Qi Y, Shriver Z, Liu D, Zhao G, Venkataraman G, Langer R, Saiserkharan R (2003) Rational design of low-molecular weight heparins with improved in vivo activity. Proc Natl Acad Sci USA 100:651-656
17. T Taguchi L Xu H Kobayashi A Taniguchi K Kataoka J Tanaka 2005 Encapsulation of chondrocytes in injectable alkali-treated collagen gels prepared using poly(ethylene glycol)-based 4-armed star polymer Biomaterials 26 1247 1252
18. S Terada H Yoshimoto JR Fuchs M Sato I Pomerantseva MK Selig D Hannouche JP Vacanti 2005 Hydrogel optimization for cultured elastic chondrocytes seeded onto a polyglycolic acid scaffold J Biomed Mater Res A 75 907 916
19. JW Yi K Na YH Bae 2004 Ionic strength/temperature-induced gelation of aqueous poly(N-isopropylacrylamide-co-vinylimidazole) solution Macromol Symp 207 131 137