메뉴 건너뛰기




Volumn 69, Issue 3, 2009, Pages 1212-1220

Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; UNCLASSIFIED DRUG; VASCULOSTATIN;

EID: 59149099562     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-1166     Document Type: Article
Times cited : (94)

References (50)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182-6.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 27944456442 scopus 로고    scopus 로고
    • The role of the extracellular matrix in angiogenesis in malignant glioma tumors
    • Wang D, Anderson JC, Gladson CL. The role of the extracellular matrix in angiogenesis in malignant glioma tumors. Brain Pathol 2005;15:318-26.
    • (2005) Brain Pathol , vol.15 , pp. 318-326
    • Wang, D.1    Anderson, J.C.2    Gladson, C.L.3
  • 3
    • 0034658412 scopus 로고    scopus 로고
    • Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells
    • Tenan M, Fulci G, Albertoni M, et al. Thrombospondin-1 is downregulated by anoxia and suppresses tumorigenicity of human glioblastoma cells. J Exp Med 2000;191:1789-98.
    • (2000) J Exp Med , vol.191 , pp. 1789-1798
    • Tenan, M.1    Fulci, G.2    Albertoni, M.3
  • 4
    • 0030856117 scopus 로고    scopus 로고
    • Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis
    • Desbaillets I, Diserens AC, Tribolet N, Hamou MF, Van Meir EG. Upregulation of interleukin 8 by oxygen-deprived cells in glioblastoma suggests a role in leukocyte activation, chemotaxis, and angiogenesis. J Exp Med 1997;186:1201-12.
    • (1997) J Exp Med , vol.186 , pp. 1201-1212
    • Desbaillets, I.1    Diserens, A.C.2    Tribolet, N.3    Hamou, M.F.4    Van Meir, E.G.5
  • 5
    • 33846149645 scopus 로고    scopus 로고
    • AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients
    • Batchelor TT, Sorensen AG, di Tomaso E, et al. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell 2007;11:83-95.
    • (2007) Cancer Cell , vol.11 , pp. 83-95
    • Batchelor, T.T.1    Sorensen, A.G.2    di Tomaso, E.3
  • 6
    • 38449114010 scopus 로고    scopus 로고
    • Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy
    • Kurozumi K, Hardcastle J, Thakur R, et al. Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy. J Natl Cancer Inst 2007;99:1768-81.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 1768-1781
    • Kurozumi, K.1    Hardcastle, J.2    Thakur, R.3
  • 7
    • 0842325802 scopus 로고    scopus 로고
    • Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population
    • Brat DJ, Castellano-Sanchez AA, Hunter SB, et al. Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population. Cancer Res 2004;64:920-7.
    • (2004) Cancer Res , vol.64 , pp. 920-927
    • Brat, D.J.1    Castellano-Sanchez, A.A.2    Hunter, S.B.3
  • 8
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-7.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 9
    • 0035880788 scopus 로고    scopus 로고
    • PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme
    • Smith JS, Tachibana I, Passe SM, et al. PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme. J Natl Cancer Inst 2001;93:1246-56.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1246-1256
    • Smith, J.S.1    Tachibana, I.2    Passe, S.M.3
  • 10
    • 0026521394 scopus 로고
    • Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails
    • Ekstrand AJ, Sugawa N, James CD, Collins VP. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc Natl Acad Sci U S A 1992;89:4309-13.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 4309-4313
    • Ekstrand, A.J.1    Sugawa, N.2    James, C.D.3    Collins, V.P.4
  • 11
    • 0021932240 scopus 로고
    • Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin
    • Libermann TA, Nusbaum HR, Razon N, et al. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin. Nature 1985;313:144-7.
    • (1985) Nature , vol.313 , pp. 144-147
    • Libermann, T.A.1    Nusbaum, H.R.2    Razon, N.3
  • 12
    • 0032577870 scopus 로고    scopus 로고
    • Cloning and characterization of BAI-associated protein 1: A PDZ domain-containing protein that interacts with BAI1
    • Shiratsuchi T, Futamura M, Oda K, et al. Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. Biochem Biophys Res Commun 1998;247:597-604.
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 597-604
    • Shiratsuchi, T.1    Futamura, M.2    Oda, K.3
  • 13
    • 9844261161 scopus 로고    scopus 로고
    • A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis
    • Nishimori H, Shiratsuchi T, Urano T, et al. A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. Oncogene 1997;15:2145-50.
    • (1997) Oncogene , vol.15 , pp. 2145-2150
    • Nishimori, H.1    Shiratsuchi, T.2    Urano, T.3
  • 14
    • 0037219173 scopus 로고    scopus 로고
    • Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression
    • Kaur B, Brat DJ, Calkins CC, Van Meir EG. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. Am J Pathol 2003;162:19-27.
    • (2003) Am J Pathol , vol.162 , pp. 19-27
    • Kaur, B.1    Brat, D.J.2    Calkins, C.C.3    Van Meir, E.G.4
  • 15
    • 0034133742 scopus 로고    scopus 로고
    • Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1)
    • Hatanaka H, Oshika Y, Abe Y, et al. Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1). Int J Mol Med 2000;5:181-3.
    • (2000) Int J Mol Med , vol.5 , pp. 181-183
    • Hatanaka, H.1    Oshika, Y.2    Abe, Y.3
  • 16
    • 13144294987 scopus 로고    scopus 로고
    • Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer
    • Fukushima Y, Oshika Y, Tsuchida T, et al. Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer. Int J Oncol 1998;13:967-70.
    • (1998) Int J Oncol , vol.13 , pp. 967-970
    • Fukushima, Y.1    Oshika, Y.2    Tsuchida, T.3
  • 17
    • 38449116226 scopus 로고    scopus 로고
    • Inhibition of tumor growth through suppression of angiogenesis by brainspecific angiogenesis inhibitor 1 gene transfer in murine renal cell carcinoma
    • Kudo S, Konda R, Obara W, et al. Inhibition of tumor growth through suppression of angiogenesis by brainspecific angiogenesis inhibitor 1 gene transfer in murine renal cell carcinoma. Oncol Rep 2007;18:785-91.
    • (2007) Oncol Rep , vol.18 , pp. 785-791
    • Kudo, S.1    Konda, R.2    Obara, W.3
  • 18
    • 33645033864 scopus 로고    scopus 로고
    • Antiangiogenic activity of BAI1 in vivo : Implications for gene therapy of human glioblastomas
    • Kang X, Xiao X, Harata M, et al. Antiangiogenic activity of BAI1 in vivo : implications for gene therapy of human glioblastomas. Cancer Gene Ther 2006;13:385-92.
    • (2006) Cancer Gene Ther , vol.13 , pp. 385-392
    • Kang, X.1    Xiao, X.2    Harata, M.3
  • 19
    • 19944379133 scopus 로고    scopus 로고
    • Kaur B, Brat DJ, Devi NS, Van Meir EG. Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor. Oncogene 2005;24:3632-42.
    • Kaur B, Brat DJ, Devi NS, Van Meir EG. Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor. Oncogene 2005;24:3632-42.
  • 20
    • 33751191637 scopus 로고    scopus 로고
    • Blockade of αvβ3 and αvβ5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells
    • Maubant S, Saint-Dizier D, Boutillon M, et al. Blockade of αvβ3 and αvβ5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells. Blood 2006;108:3035-44.
    • (2006) Blood , vol.108 , pp. 3035-3044
    • Maubant, S.1    Saint-Dizier, D.2    Boutillon, M.3
  • 21
    • 0036104828 scopus 로고    scopus 로고
    • Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor
    • Volpert OV, Zaichuk T, Zhou W, et al. Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat Med 2002;8:349-57.
    • (2002) Nat Med , vol.8 , pp. 349-357
    • Volpert, O.V.1    Zaichuk, T.2    Zhou, W.3
  • 22
    • 0026667093 scopus 로고
    • Disulfides modulate RGD-inhibitable cell adhesive activity of thrombospondin
    • Sun X, Skorstengaard K, Mosher DF. Disulfides modulate RGD-inhibitable cell adhesive activity of thrombospondin. J Cell Biol 1992;118:693-701.
    • (1992) J Cell Biol , vol.118 , pp. 693-701
    • Sun, X.1    Skorstengaard, K.2    Mosher, D.F.3
  • 23
    • 0041382820 scopus 로고    scopus 로고
    • The hypoxic response of tumors is dependent on their microenvironment
    • Blouw B, Song H, Tihan T, et al. The hypoxic response of tumors is dependent on their microenvironment. Cancer Cell 2003;4:133-46.
    • (2003) Cancer Cell , vol.4 , pp. 133-146
    • Blouw, B.1    Song, H.2    Tihan, T.3
  • 24
    • 0036281013 scopus 로고    scopus 로고
    • Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells
    • Mori K, Kanemura Y, Fujikawa H, et al. Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells. Neurosci Res 2002;43:69-74.
    • (2002) Neurosci Res , vol.43 , pp. 69-74
    • Mori, K.1    Kanemura, Y.2    Fujikawa, H.3
  • 25
    • 0032977124 scopus 로고    scopus 로고
    • Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines
    • Ishii N, Maier D, Merlo A, et al. Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines. Brain Pathol 1999;9:469-79.
    • (1999) Brain Pathol , vol.9 , pp. 469-479
    • Ishii, N.1    Maier, D.2    Merlo, A.3
  • 26
    • 0028146767 scopus 로고
    • A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity
    • Nishikawa R, Ji XD, Harmon RC, et al. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci U S A 1994;91:7727-31.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 7727-7731
    • Nishikawa, R.1    Ji, X.D.2    Harmon, R.C.3
  • 27
    • 0032567491 scopus 로고    scopus 로고
    • Recombinant glutathione S-transferase/CD36 fusion proteins define an oxidized low density lipoprotein-binding domain
    • Pearce SF, Roy P, Nicholson AC, et al. Recombinant glutathione S-transferase/CD36 fusion proteins define an oxidized low density lipoprotein-binding domain. J Biol Chem 1998;273:34875-81.
    • (1998) J Biol Chem , vol.273 , pp. 34875-34881
    • Pearce, S.F.1    Roy, P.2    Nicholson, A.C.3
  • 28
    • 0024478054 scopus 로고
    • p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor
    • Hudziak RM, Lewis GD, Winget M, et al. p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor. Mol Cell Biol 1989;9:1165-72.
    • (1989) Mol Cell Biol , vol.9 , pp. 1165-1172
    • Hudziak, R.M.1    Lewis, G.D.2    Winget, M.3
  • 29
    • 0031562572 scopus 로고    scopus 로고
    • Identification of nude mice in tumorigenicity assays
    • Van Meir EG. Identification of nude mice in tumorigenicity assays. Int J Cancer 1997;71:310.
    • (1997) Int J Cancer , vol.71 , pp. 310
    • Van Meir, E.G.1
  • 30
    • 4043124035 scopus 로고    scopus 로고
    • Efficacy of adenoviral p53 delivery with SCH58500 in the intracranial 9l and RG2 models
    • Bowers G, He J, Schulz K, et al. Efficacy of adenoviral p53 delivery with SCH58500 in the intracranial 9l and RG2 models. Front Biosci 2003;8:a54-61.
    • (2003) Front Biosci , vol.8
    • Bowers, G.1    He, J.2    Schulz, K.3
  • 33
    • 0037699025 scopus 로고    scopus 로고
    • PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli
    • Abe T, Terada K, Wakimoto H, et al. PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli. Cancer Res 2003;63:2300-5.
    • (2003) Cancer Res , vol.63 , pp. 2300-2305
    • Abe, T.1    Terada, K.2    Wakimoto, H.3
  • 35
    • 0030833817 scopus 로고    scopus 로고
    • CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells
    • Dawson DW, Pearce SF, Zhong R, et al. CD36 mediates the In vitro inhibitory effects of thrombospondin-1 on endothelial cells. J Cell Biol 1997;138:707-17.
    • (1997) J Cell Biol , vol.138 , pp. 707-717
    • Dawson, D.W.1    Pearce, S.F.2    Zhong, R.3
  • 36
    • 0026567377 scopus 로고
    • Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro
    • Swerlick RA, Lee KH, Wick TM, Lawley TJ. Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro . J Immunol 1992;148:78-83.
    • (1992) J Immunol , vol.148 , pp. 78-83
    • Swerlick, R.A.1    Lee, K.H.2    Wick, T.M.3    Lawley, T.J.4
  • 37
    • 4344701559 scopus 로고    scopus 로고
    • Cd36: A critical anti-angiogenic receptor
    • Simantov R, Silverstein RL. Cd36: a critical anti-angiogenic receptor. Front Biosci 2003;8:S874-82.
    • (2003) Front Biosci , vol.8
    • Simantov, R.1    Silverstein, R.L.2
  • 38
    • 0342445431 scopus 로고    scopus 로고
    • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
    • Jimenez B, Volpert OV, Crawford SE, et al. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med 2000;6:41-8.
    • (2000) Nat Med , vol.6 , pp. 41-48
    • Jimenez, B.1    Volpert, O.V.2    Crawford, S.E.3
  • 39
    • 10744227896 scopus 로고    scopus 로고
    • Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking αvβ5 integrin
    • Koh JT, Kook H, Kee HJ, et al. Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking αvβ5 integrin. Exp Cell Res 2004;294:172-84.
    • (2004) Exp Cell Res , vol.294 , pp. 172-184
    • Koh, J.T.1    Kook, H.2    Kee, H.J.3
  • 41
    • 15344342865 scopus 로고    scopus 로고
    • Functional evolution of ADAMTS genes: Evidence from analyses of phylogeny and gene organization
    • Nicholson AC, Malik SB, Logsdon JM, Jr., Van Meir EG. Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization. BMC Evol Biol 2005;5:11.
    • (2005) BMC Evol Biol , vol.5 , pp. 11
    • Nicholson, A.C.1    Malik, S.B.2    Logsdon Jr., J.M.3    Van Meir, E.G.4
  • 42
    • 42949124644 scopus 로고    scopus 로고
    • Heparin-induced cis- and trans- dimerization modes of the thrombospondin-1 N-terminal domain
    • Tan K, Duquette M, Liu JH, et al. Heparin-induced cis- and trans- dimerization modes of the thrombospondin-1 N-terminal domain. J Biol Chem 2007;283:3932-41.
    • (2007) J Biol Chem , vol.283 , pp. 3932-3941
    • Tan, K.1    Duquette, M.2    Liu, J.H.3
  • 43
    • 36248987290 scopus 로고    scopus 로고
    • BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module
    • Park D, Tosello-Trampont AC, Elliott MR, et al. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 2007;450:430-4.
    • (2007) Nature , vol.450 , pp. 430-434
    • Park, D.1    Tosello-Trampont, A.C.2    Elliott, M.R.3
  • 44
    • 34548219477 scopus 로고    scopus 로고
    • ABT-510, a modified type 1 repeat peptide of thrombospondin, inhibits malignant glioma growth in vivo by inhibiting angiogenesis
    • Anderson JC, Grammer JR, Wang W, et al. ABT-510, a modified type 1 repeat peptide of thrombospondin, inhibits malignant glioma growth in vivo by inhibiting angiogenesis. Cancer Biol Ther 2007;6:454-62.
    • (2007) Cancer Biol Ther , vol.6 , pp. 454-462
    • Anderson, J.C.1    Grammer, J.R.2    Wang, W.3
  • 45
    • 0031983724 scopus 로고    scopus 로고
    • Identification of a CD36-related thrombospondin 1-binding domain in HIV-1 envelope glycoprotein gp120: Relationship to HIV-1-specific inhibitory factors in human saliva
    • Crombie R, Silverstein RL, MacLow C, et al. Identification of a CD36-related thrombospondin 1-binding domain in HIV-1 envelope glycoprotein gp120: relationship to HIV-1-specific inhibitory factors in human saliva. J Exp Med 1998;187:25-35.
    • (1998) J Exp Med , vol.187 , pp. 25-35
    • Crombie, R.1    Silverstein, R.L.2    MacLow, C.3
  • 46
    • 0032570699 scopus 로고    scopus 로고
    • Lysosomal integral membrane protein II binds thrombospondin-1. Structure-function homology with the cell adhesion molecule CD36 defines a conserved recognition motif
    • Crombie R, Silverstein R. Lysosomal integral membrane protein II binds thrombospondin-1. Structure-function homology with the cell adhesion molecule CD36 defines a conserved recognition motif. J Biol Chem 1998;273:4855-63.
    • (1998) J Biol Chem , vol.273 , pp. 4855-4863
    • Crombie, R.1    Silverstein, R.2
  • 47
    • 33846228382 scopus 로고    scopus 로고
    • Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancers
    • Rusk A, McKeegan E, Haviv F, et al. Preclinical evaluation of antiangiogenic thrombospondin-1 peptide mimetics, ABT-526 and ABT-510, in companion dogs with naturally occurring cancers. Clin Cancer Res 2006;12:7444-55.
    • (2006) Clin Cancer Res , vol.12 , pp. 7444-7455
    • Rusk, A.1    McKeegan, E.2    Haviv, F.3
  • 48
    • 34249990658 scopus 로고    scopus 로고
    • A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma
    • Markovic SN, Suman VJ, Rao RA, et al. A phase II study of ABT-510 (thrombospondin-1 analog) for the treatment of metastatic melanoma. Am J Clin Oncol 2007;30:303-9.
    • (2007) Am J Clin Oncol , vol.30 , pp. 303-309
    • Markovic, S.N.1    Suman, V.J.2    Rao, R.A.3
  • 49
    • 48349119172 scopus 로고    scopus 로고
    • Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61
    • Kurozumi K, Hardcastle J, Thakur R, et al. Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61. Mol Ther 2008;16:1382-91.
    • (2008) Mol Ther , vol.16 , pp. 1382-1391
    • Kurozumi, K.1    Hardcastle, J.2    Thakur, R.3
  • 50
    • 11144229120 scopus 로고    scopus 로고
    • Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors
    • Post DE, Devi NS, Li Z, et al. Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors. Clin Cancer Res 2004;10:8603-12.
    • (2004) Clin Cancer Res , vol.10 , pp. 8603-8612
    • Post, D.E.1    Devi, N.S.2    Li, Z.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.