Multigenic control of tuberculosis resistance: Analysis of a QTL on mouse chromosome 7 and its synergism with sst1

Genes and Immunity

Volumn 10, Issue 1, 2009, Pages 37-46

  Sissons, J ^a   Yan, B S ^a,c   Pichugin, A V ^a   Kirby, A ^b   Daly, M J ^b   Kramnik, I ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; SUPERSUSCEPTIBILITY TO TUBERCULOSIS 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 7; DISEASE COURSE; GENE FREQUENCY; GENE IDENTIFICATION; GENE INTERACTION; GENE LOCUS; GENETIC VARIABILITY; GENOME ANALYSIS; HOMOZYGOSITY; HOST RESISTANCE; IMMUNE RESPONSE; INFECTION CONTROL; INFECTION RESISTANCE; INFECTION SENSITIVITY; MOUSE; MULTIGENE FAMILY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; QUANTITATIVE TRAIT LOCUS MAPPING; SINGLE NUCLEOTIDE POLYMORPHISM;

ALLELES; ANIMALS; CHROMOSOMES, MAMMALIAN; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; EPISTASIS, GENETIC; GENETIC PREDISPOSITION TO DISEASE; LINKAGE (GENETICS); LOD SCORE; MALE; MICE; MICE, CONGENIC; MICE, INBRED C3H; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; PHYSICAL CHROMOSOME MAPPING; QUANTITATIVE TRAIT LOCI; STATISTICS, NONPARAMETRIC; TUBERCULOSIS;

ANIMALIA; MYCOBACTERIUM TUBERCULOSIS;

EID: 59149091708     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2008.68     Document Type: Article

References (31)

1. WHO. Global tuberculosis control - surveillance, planning, financing. WHO Report 2006.
2. Schurr E. Is susceptibility to tuberculosis acquired or inherited? J Intern Med 2007; 261: 106-111.
3. Britton WJ, Fernando SL, Saunders BM, Sluyter R, Wiley JS. The genetic control of susceptibility to Mycobacterium tuberculosis. Novartis Found Symp 2007; 281: 79-89; discussion 89-92, 208-209.
4. Hill AV. Aspects of genetic susceptibility to human infectious diseases. Annu Rev Genet 2006; 40: 469-486.
5. Hill AV. The genomics and genetics of human infectious disease susceptibility. Annu Rev Genomics Hum Genet 2001; 2: 373-400.
6. Buschman E, Apt AS, Nickonenko BV, Moroz AM, Averbakh MH, Skamene E. Genetic aspects of innate resistance and acquired immunity to mycobacteria in inbred mice. Springer Semin Immunopathol 1988; 10: 319-336.
7. Lurie MB, Zappasodi P, Dannenberg Jr AM, Weiss GH. On the mechanism of genetic resistance to tuberculosis and its mode of inheritance. American Journal of Human Genetics 1952; 4: 302-314.
8. Lynch CJ, Pierce-Chase CH, Dubos R. A genetic study of susceptibility to experimental tuberculosis in mice infected with mammalian tubercle bacilli. J Exp Med 1965; 121: 1051-1070.
9. Medina E, North RJ. Genetically susceptible mice remain proportionally more susceptible to tuberculosis after vaccination. Immunology 1999; 96: 16-21.
10. Ulrichs T, Kaufmann SH. New insights into the function of granulomas in human tuberculosis. J Pathol 2006; 208: 261-269.
11. Fortin A, Abel L, Casanova JL, Gros P. Host genetics of mycobacterial diseases in mice and men: Forward genetic studies of BCG-osis and tuberculosis. Annu Rev Genomics Hum Genet 2007; 8: 163-192.
12. North RJ, Jung YJ. Immunity to tuberculosis. Annu Rev Immunol 2004; 22: 599-623.
13. Sanchez F, Radaeva TV, Nikonenko BV, Persson AS, Sengul S, Schalling M et al. Multigenic control of disease severity after virulent Mycobacterium tuberculosis infection in mice. Infect Immun 2003; 71: 126-131.
14. Kramnik I, Demant P, Bloom BB. Susceptibility to tuberculosis as a complex genetic trait: Analysis using recombinant congenic strains of mice. Novartis Found Symp 1998; 217: 120-131; discussion 32-37.
15. Lavebratt C, Apt AS, Nikonenko BV, Schalling M, Schurr E. Severity of tuberculosis in mice is linked to distal chromosome 3 and proximal chromosome 9. J Infect Dis 1999; 180: 150-155.
16. Mitsos LM, Cardon LR, Fortin A, Ryan L, LaCourse R, North RJ et al Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice. Genes Immun 2000; 1: 467-477.
17. Mitsos LM, Cardon LR, Ryan L, LaCourse R, North RJ, Gros P. Susceptibility to tuberculosis: A locus on mouse chromosome 19 (Trl-4) regulates Mycobacterium tuberculosis replication in the lungs. Proc Natl Acad Sci USA 2003; 100: 6610-6615.
18. Yan BS, Kirby A, Shebzukhov YV, Daly MJ, Kramnik I. Genetic architecture of tuberculosis resistance in a mouse model of infection. Genes Immun 2006; 7: 201-210.
19. Kramnik I, Dietrich WF, Demant P, Bloom BR. Genetic control of resistance to experimental infection with virulent Mycobacterium tuberculosis. Proc Natl Acad Sci USA 2000; 97: 8560-8565.
20. Yan BS, Pichugin AV, Jobe O, Helming L, Eruslanov EB, Gutierrez-Pabello JA et al. Progression of pulmonary tuberculosis and efficiency of bacillus Calmette-Guerin vaccination are genetically controlled via a common sst1-mediated mechanism of innate immunity. J Immunol 2007; 179: 6919-6932.
21. Pan H, Yan BS, Rojas M, Shebzukhov YV, Zhou H, Kobzik L et al. Ipr1 gene mediates innate immunity to tuberculosis. Nature 2005; 434: 767-772.
22. Flint J, Valdar W, Shifman S, Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nat Rev Genet 2005; 6: 271-286.
23. Boyartchuk VL, Broman KW, Mosher RE, D'Orazio SE, Starnbach MN, Dietrich WF. Multigenic control of Listeria monocytogenes susceptibility in mice. Nat Genet 2001; 27: 259-260.
24. Vidal SM, Malo D, Marquis JF, Gros P. Forward genetic dissection of immunity to infection in the mouse. Annu Rev Immunol 2008; 26 81-132.
25. Wakeland E, Morel L, Achey K, Yui M, Longmate J. Speed congenics: A classic technique in the fast lane (relatively speaking). Immunol Today 1997; 18: 472-477.
26. Krog HH, Moutier R. Identification of inbred strains of mice: II. Characterization of different substrains of the C3H strain. J Hered 1978; 69: 66-70.
27. Kamath AB, Alt J, Debbabi H, Taylor C, Behar SM. The major histocompatibility complex haplotype affects T-cell recognition of mycobacterial antigens but not resistance to Mycobacterium tuberculosis in C3H mice. Infect Immun 2004; 72: 6790-6798.
28. Chackerian AA, Behar SM. Susceptibility to Mycobacterium tuberculosis: lessons from inbred strains of mice. Tuberculosis (Edinb) 2003; 83: 279-285.
29. Cervino A, Lakiss S, Sow O, Bellamy R, Beyers N, Hoal-van Helden E et al. Fine mapping of a putative tuberculosis-susceptibility locus on chromosome 15q11-13 in African families. Hum Mol Genet 2002; 14 1599-1603.
30. Scheffner M, Huibregtse JM, Vierstra RD, Howley PM. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 1993; 3: 495-505.
31. Symons RC, Daly MJ, Fridlyand J, Speed TP, Cook WD, Gerondakis S et al. Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice. Proc Natl Acad Sci USA 2002; 99: 11299-11304.