Nociceptive vascular reflexes evoked by scorpion venom modulate cardiorespiratory parameters involving vanilloid receptor 1 in anaesthetised rats

Neuroscience Letters

Volumn 451, Issue 3, 2009, Pages 194-198

  Singh, Sanjeev K ^a   Deshpande, Shripad B ^a  

^a BANARAS HINDU UNIVERSITY   (India)

Author keywords

5 HT3 receptors; Perivascular afferents; Vanilloid receptors; Vascular reflexes

Indexed keywords

CAPSAZEPINE; LIDOCAINE; ONDANSETRON; SCORPION VENOM; SEROTONIN 3 RECEPTOR; VANILLOID RECEPTOR 1;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE; BRADYCARDIA; BREATHING RATE; CARDIORESPIRATORY PARAMETER; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART RATE; HYPERTENSION; MALE; NERVE; NOCICEPTION; NONHUMAN; PARAMETER; PRESSOR RESPONSE; PRIORITY JOURNAL; RAT; SENSORY NERVE; SOMATIC NERVE; TACHYPNEA; VASOMOTOR REFLEX;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; BLOOD PRESSURE; BLOOD VESSELS; CAPSAICIN; CARDIOVASCULAR PHYSIOLOGICAL PHENOMENA; DRUG INTERACTIONS; HEART RATE; INJECTIONS, INTRA-ARTERIAL; LIDOCAINE; MALE; NOCICEPTORS; RATS; RECEPTORS, SEROTONIN, 5-HT3; REFLEX; RESPIRATORY PHYSIOLOGICAL PHENOMENA; SCORPION VENOMS; SENSORY RECEPTOR CELLS; SEROTONIN; TIME FACTORS; TRPV CATION CHANNELS; VISCERAL AFFERENTS;

EID: 59149087141     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.01.012     Document Type: Article

References (25)

1. Best C.H., and Taylor N.B. The autonomic nervous system. In the Physiological Basis of Medical Practice. 8th ed. (1966), Williams and Wilkins Company, Baltimore pp. 242-261 (Chapter 12)
2. Deshpande S.B., and Alex A.B. On the management of scorpion stings. Heart 83 (2000) 585-586
3. Deshpande S.B., Bagchi S., Rai O.P., and Arya N.C. Pulmonary oedema produced by scorpion venom augments phenyldiguanide-induced reflex response in anaesthetized rats. J. Physiol. 521 (1999) 537-544
4. Donnerer J., and Lembeck F. Analysis of the effects of intravenously injected capsaicin in the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 320 (1982) 54-57
5. Donnerer J., and Lembeck F. Capsaicin-induced reflex fall in rat blood pressure is mediated by afferent substance P-containing neurons via a reflex centre in the brainstem. Naunyn-Schmiedeberg's Arch. Pharmacol. 324 (1983) 293-295
6. Ganong W.F. Regulation of respiration. Review of Medical Physiology. 20th ed. (2001), Lange Medical Books, New York p. 657 (Chapter 36)
7. 3 receptor mediation of pain and anti-nociception: implications for clinical therapeutics. Pain Phys. 7 (2004) 141-147
8. Gwee M.C., Nirthanan S., Khoo H.E., Gopalakrishnakone P., Kini R.M., and Cheah L.S. Autonomic effects of some scorpion venoms and toxins. Clin. Exp. Pharmacol. Physiol. 29 (2002) 795-801
9. Hanna R.L., Hayes S.G., and Kaufman M.P. α,β-MeATP elicits a reflex pressor response arising from muscle in decerebrate cats. J. Appl. Physiol. 93 (2002) 834-841
10. Hainsworth R. Reflexes from the heart. Physiol. Rev. 71 (1991) 617-658
11. Julius D., and Basbaum A.I. Molecular mechanisms of nociception. Nature 413 (2001) 203-210
12. Kostreva D.R., Hopp F.A., and Kampine J.P. Depressor responses to stimulation of sympathetic afferents in monkeys and dogs. Am. J. Physiol. 240 (1981) R23-28
13. Linz P., Amann K., Freisinger W., Ditting T., Hilgers K.F., and Veelken R. Sensory neurons with afferents from hind limb: enhanced sensitivity in secondary hypertension. Hypertension 47 (2006) 527-531
14. Malliani A., Lombardi F., and Pagani M. Functions of afferents in cardiovascular sympathetic nerves. J. Auton. Nerv. Syst. 3 (1981) 231-236
15. Marshall J.M. Peripheral chemoreceptors and cardiovascular regulations. Physiol. Rev. 74 (1994) 543-594
16. Moskowitz M.A. Basic mechanisms in vascular headache. Neurol. Clin. 8 (1990) 801-815
17. Murthy K.R.K., Shenoi R., Vaidyanathan P., Kelkar K., Sharma N., Birewar N., Rao S., and Mehta M.N. Insulin reverses hemodynamic changes and pulmonary oedema in children stung by Indian red scorpion Mesobuthus tumulus concanensis. Pocock. Ann. Trop. Med. Parasit. 85 (1991) 651-657
18. Murthy K.R.K., Vakil A.E., Yeolekar M.E., and Vakil Y.E. Reversal of metabolic & electocardiographic changes induced by Indian red scorpion (Buthus tamulus) venom by administration of insulin, alpha blocker & sodium bicarbonate. Ind. J. Med. Res. 88 (1988) 450-457
19. 3 receptor-induced currents in N1E-115 neuroblastoma cells. Eur. J. Pharmacol. 151 (1988) 491-495
20. Singh S.K., and Deshpande S.B. Intra-arterial injection of Mesobuthus tamulus venom elicits cardiorespiratory reflexes involving perivascular afferents. Toxicon 46 (2005) 820-826
21. Singh S.K., and Deshpande S.B. Injection of Mesobuthus tamulus venom in distal segment of femoral artery evokes hyperventilatory and hypertensive responses in anaesthetised rats. Neurosci. Lett. 438 (2008) 64-66
22. Singh S.K., and Deshpande S.B. Vasosensory responses elicited by Indian red scorpion venom last longer than the capsaicin-induced responses. Ind. J. Exp. Biol. 46 (2008) 755-759
23. Smith P.J.W., and McQueen D.S. Anandamide induces cardiovascular and respiratory reflexes via vasosensory nerves in anaesthetized rat. Br. J. Pharmacol. 134 (2001) 655-663
24. Smith P.J.W., and McQueen D.S. Perivascular nerves induce cardiorepiratory reflexes in response to algogens in anaesthetised rats. Neurosci. Res. 50 (2004) 271-281
25. Tiwari A.K., and Deshpande S.B. Toxicity of scorpion (Buthus tamulus) in mammals is influenced by the age and species. Toxicon 31 (1993) 1619-1622