Stress-induced hyperglycemia in patients with severe sepsis: A compromising factor for survival

American Journal of the Medical Sciences

Volumn 336, Issue 6, 2008, Pages 467-471

  Leonidou, Leonidia ^a   Michalaki, Marina ^a   Leonardou, Ageliki ^a   Polyzogopoulou, Eftihia ^a   Fouka, Kalliopi ^b   Gerolymos, Miltiadis ^c   Leonardos, Pantelis ^c   Psirogiannis, Agathoklis ^a   Kyriazopoulou, Venetsana ^a   Gogos, Charalambos A ^a,d  

^a UNIVERSITY HOSPITAL OF PATRAS   (Greece)

^b Patras General University Hospital   (Greece)

^c Department of Internal Medicine   (Greece)

^d UNIVERSITY OF PATRAS   (Greece)

Author keywords

Diabetes melitus; Infection; Sepsis; Stress hyperglycemia; Survival

Indexed keywords

GLUCOSE;

AGED; ARTICLE; CONTROLLED STUDY; DEATH; DIABETES MELLITUS; DISEASE SEVERITY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC INDEX; GREECE; HOSPITAL ADMISSION; HUMAN; HYPERGLYCEMIA; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; PROGNOSIS; SCORING SYSTEM; SEPSIS; STRESS; SURVIVAL; ANIMAL; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; PROSPECTIVE STUDY; SURVIVAL RATE;

AGED; AGED, 80 AND OVER; ANIMALS; FEMALE; HUMANS; HYPERGLYCEMIA; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SEPSIS; STRESS, PHYSIOLOGICAL; SURVIVAL RATE;

EID: 59049106556     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e318176abb4     Document Type: Article

References (27)

1. Longarela A, Olarra J, Suarez L, et al. Metabolic response to stress, can we control it? [review] Nutr Hosp 2000;15: 275-9. Spanish.
2. Gearhart MM, Parbhoo SK. Hyperglycemia in the critically ill patient. AACN Clin Issues 2006;17:50-5.
3. Marik PE, Raghavan M. Stress-hyperglycemia, insulin and immunomodulation in sepsis. Intensive Care Med 2004; 30: 748-56.
4. Zindrou D, Taylor KM, Bagger JP. Admission plasma glucose: an independent risk factor in nondiabetic women after coronary artery bypasses grafting. Diabetes Care 2001; 24:1634-9.
5. Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003;78:1471-8.
6. Malmberg K, Norhammar A, Wedel H, et al. Glycometabolic state at admission: important risk marker of mortality in conventionally treated patients with diabetes mellitus and acute myocardial infarction: long-term results from the Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) study. Circulation 1999;99:2626-32.
7. Malmberg K. Prospective randomised study of intensive insulin treatment on long-term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myo-cardial Infarction) Study Group. Br Med J 1997;314:1512-15.
8. Malmberg K, Ryden L, Efendic S, et al. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): effects on mortality at 1 year. J Am Coll Cardiol 1995;26:57-65.
9. Capes SE, Hunt D, Malmberg K, et al. HC stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke 2001;32:2426-32.
10. Woo J, Lam CW, Kay R, et al. The influence of hyperglycemia and diabetes mellitus on immediate and 3-month morbidity and mortality after acute stroke. Arch Neurol 1990;47: 1174-7.
11. Cheung NW, Napier B, Zaccaria C, et al. Hyperglycemia is associated with adverse outcomes in patients receiving total parenteral nutrition. Diabetes Care 2005;28:2367-71.
12. Baker EH, Janaway CH, Philips BJ, et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax 2006;61:284-9.
13. Heuer JG, Sharma GR, Zhang T, et al. Effects of hyperglycemia and insulin therapy on outcome in a hyperglycemic septic model of critical illness. J Trauma 2006;60:865-72.
14. Losser MR, Bernard C, Beaudeux JL, et al. Glucose modulates hemodynamic, metabolic, and inflammatory responses to lipopolysaccharide in rabbits. J Appl Physiol 1997; 83:1566-74.
15. American College of Chest Physicians/Society of Critical Medicine Consensus Committee: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;20:864-74.
16. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ ESICM/ACCP/ATS/SIS. International Sepsis Definitions Conference. Crit Care Med 2003;31:1250-6.
17. Hotchkiss RS, Karl IE. The pathopsysiology and treatment of sepsis. N Engl J Med 2003;348:138-50.
18. Laird AM, Miller PR, Kilgo PD, et al. Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 2004;56:1058-62.
19. Bochicchio GV, Sung J, Joshi M, et al. Persistent hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005;58:921-4.
20. Rovlias A, Serafim K. The influence of hyperglycemia on neurological outcome in patients with severe head injury. Neurosurgery 2000;46:335-42.
21. Jeremitsky E, Omert LA, Dunham CM, et al. The impact of hyperglycemia on patients with severe brain injury. J Trauma 2005;58:47-50.
22. Kagansky N, Levy S, Knobler H. The role of hyperglycemia in acute stroke. Arch Neurol 2001;58:1209-12.
23. Gyurko R, Siqueira C, Caldon N, et al. Chronic hyperglycemia predisposes to exaggerated inflammatory response and leukocyte dysfunction in Akita mice. J Immunol 2006;177: 7250-6.
24. Delamaire M, Maugedre D, Moreno M, et al. Impaired leucocyte functions in diabetic patients. Diabet Med 1997;14: 29-34.
25. Krogh-Madsen R, Moller K, Dela F, et al. Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-α, and FFAs to low dose endotoxemia in humans. Am J Physiol Endocrinol Metab 2004;286:E766-E772.
26. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med 2001;345:1359-67.
27. van den Berghe G, Wouters PJ, Bouillon R, et al. Outcome benefit of intensive insulin therapy in the critically ill: insulin dose versus glycemic control. Crit Care Med 2003;31: 359-66.