Gamma glutamyl semialdehyde dehydrogenase: Simulations on native and mutant forms support the importance of outer shell lysines

Chemico-Biological Interactions

Volumn 178, Issue 1-3, 2009, Pages 75-78

  Hempel, John ^a   Kraut, Adam ^b   Wymore, Troy ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b PITTSBURGH SUPERCOMPUTING CENTER   (United States)

Author keywords

Aldehyde dehydrogenase; Catalytic mechanism; Enzyme family; Hyperprolinemia; Main chain amide proton; Proton transfer; QM MM simulation

Indexed keywords

GLUTAMATE GAMMA SEMIALDEHYDE DEHYDROGENASE; LYSINE;

ARTICLE; CATALYSIS; HYDROGEN BOND; HYPERPROLINEMIA; HYPOTHESIS; MENTAL DEFICIENCY; MUTANT; MUTATION; SIMULATION;

1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE; CATALYTIC DOMAIN; LYSINE; MODELS, MOLECULAR; MUTATION; THERMUS THERMOPHILUS;

THERMUS THERMOPHILUS;

EID: 59049098655     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.10.009     Document Type: Article

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