Using multifocal ERG ring ratios to detect and follow Plaquenil retinal toxicity: A review

Documenta Ophthalmologica

Volumn 118, Issue 1, 2009, Pages 29-36

  Lyons, Jonathan S ^a,b   Severns, Matthew L ^c  

^a GEORGETOWN UNIVERSITY   (United States)

^b LKC Technologies Inc ^*  (United States)

^c LKC Technologies Inc   (United States)

Author keywords

Hydroxychloroquine; mfERG; Multifocal ERG; Plaquenil; Ring ratio

Indexed keywords

HYDROXYCHLOROQUINE;

ACTION POTENTIAL; ADOLESCENT; ADULT; AGED; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG WITHDRAWAL; ELECTRORETINOGRAPHY; EYE TOXICITY; HUMAN; MAJOR CLINICAL STUDY; MULTIFOCAL ELECTRORETINOGRAPHY; RETINAL TOXICITY; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; TOXICITY TESTING; VISUAL FIELD DEFECT; VISUAL IMPAIRMENT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIRHEUMATIC AGENTS; AUTOIMMUNE DISEASES; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION; ELECTRORETINOGRAPHY; FEMALE; HUMANS; HYDROXYCHLOROQUINE; MALE; MIDDLE AGED; RETINAL DISEASES; SENSITIVITY AND SPECIFICITY; VISUAL ACUITY; VISUAL FIELDS;

EID: 59049098178     PISSN: 00124486     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10633-008-9130-0     Document Type: Conference Paper

References (15)

1. Finbloom DS, Silver K, Newsome DA, Gunkel R (1985) Comparison of hydroxychloroquine and chloroquine use and the development of retinal toxicity. J Rheumatol 12:692-694
2. Bernstein HN (1991) Ocular safety of hydroxychloroquine. Ann Ophthalmol 23:292-296
3. Levy GD, Munz SJ, Paschal J, Cohen HB, Pince KJ, Peterson T (1997) Incidence of hydroxychloroquine retinopathy in 1,207 patients in a large multicenter outpatient practice. Arthritis Rheum 40:1482-1486
4. Lyons JS, Severns ML (2007) Detection of early hydroxychloroquine retinal toxicity enhanced by ring ratio analysis of multifocal electroretinography. Am J Ophthalmol 143:801-809
5. Marmor MF, Hood DC, Keating D et al (2003) Guidelines for basic multifocal electroretinography (mfERG). Doc Ophthalmol 106:105-115
6. Hood DC, Bach M, Brigell M et al (2008) ISCEV guidelines for clinical multifocal electroretinography (2007 edition). Doc Ophthalmol 116:1-11
7. Johnson MW, Vine AK (1987) Hydroxychloroquine therapy in massive total doses without retinal toxicity. Am J Ophthalmol 104:139-144
8. Maturi RK, Folk JC, Nichols B, Oetting TT, Kardon RH (1999) Hydroxychloroquine reti-nopathy. Arch Ophthalmol 117:1262-1263
9. Maturi RK, Yu M, Weleber RG (2004) Multifocal electroretinographic evaluation of long-term hydroxychloroquine users. Arch Ophthalmol 122:973-981
10. Lai TY, Chan WM, Li H, Lai RY, Lam DS (2005) Multifocal electroretinographic changes in patients receiving hydroxychloroquine therapy. Am J Ophthalmol 140:794-807
11. Seiple W, Vajaranant TS, Szlyk J et al (2003) Multifocal electroretinography as a function of age: The importance of normative values for older adults. Invest Ophthalmol Vis Sci 44:1783-1792
12. Tzekov RT, Gerth C, Werner JS (2004) Senescence of human multifocal electroretinogram components: A localized approach. Graefes Arch Clin Exp Ophthalmol 242:549-608
13. Raz D, Seeliger MW, Geva AB, Percicot CL, Lambrou GN, Ofri R (2002) The effect of contrast and luminance on mfERG responses in a monkey model of glaucoma. Invest Ophthalmol Vis Sci 43:2027-2035
14. Kim CB, VerHoeve JN, Kaufman PL, Nork TM (2005) Effects of reference electrode location on monopolar-derived multifocal electroretinograms in cynomolgus monkeys. Doc Ophthalmol 111:113-125
15. Fortune B, Johnson CA (2002) Decline of photopic multifocal electroretinogram responses with age is due primarily to preretinal optical factors. J Opt Soc Am A Opt Image Sci Vis 19:173-184