Quantification of the HIV-integrase inhibitor raltegravir and detection of its main metabolite in human plasma, dried blood spots and peripheral blood mononuclear cell lysate by means of high-performance liquid chromatography tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 2, 2009, Pages 451-458

  ter Heine, R ^a   Hillebrand, M J X ^a   Rosing, H ^a   van Gorp, E C M ^a   Mulder, J W ^a   Beijnen, J H ^a   Huitema, A D R ^a  

^a SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

Dried blood spots; HIV; LC MS MS; Pharmacology; Raltegravir

Indexed keywords

ACETONITRILE; DIBENZEPIN; METHANOL; RALTEGRAVIR; ZINC SULFATE;

ARTICLE; CELL LYSATE; DRUG DETERMINATION; DRUG MONITORING; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ACETONITRILES; ANTIVIRAL AGENTS; BIOLOGICAL ASSAY; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DESICCATION; DRUG MONITORING; DRUG STABILITY; DRUG STORAGE; FREEZING; HIV INFECTIONS; HIV INTEGRASE INHIBITORS; HUMANS; LEUKOCYTES, MONONUCLEAR; METHANOL; MOLECULAR STRUCTURE; PARTICLE SIZE; PYRROLIDINONES; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLUTIONS; TANDEM MASS SPECTROMETRY; WATER; ZINC SULFATE;

EID: 59049096346     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.11.025     Document Type: Article

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