Stimulating personality: Ethical criteria for deep brain stimulation in psychiatric patients and for enhancement purposes

Biotechnology Journal

Volumn 3, Issue 12, 2008, Pages 1511-1520

  Synofzik, Matthis ^a   Schlaepfer, Thomas E ^b,c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Deep brain stimulation; Ethics; Major depression; Neuroenhancement; Obsessive compulsive disorder

Indexed keywords

BRAIN COMPUTER INTERFACE; DISEASES; PHILOSOPHICAL ASPECTS;

DEEP BRAIN STIMULATION; ETHICS; MAJOR DEPRESSIONS; NEUROENHANCEMENT; OBSESSIVE COMPULSIVE DISORDERS;

NEUROSURGERY;

BENEFICENCE; BIOETHICS; BRAIN DEPTH STIMULATION; COGNITION; DYSTONIA; EMOTION; ESSENTIAL TREMOR; HUMAN; MAJOR DEPRESSION; MEDICAL ETHICS; MENTAL DISEASE; MENTAL PATIENT; MOTOR DYSFUNCTION; NEUROLOGIC DISEASE; NEUROMODULATION; OBSESSIVE COMPULSIVE DISORDER; PARKINSON DISEASE; PERSONAL AUTONOMY; PERSONALITY; PRIORITY JOURNAL; REVIEW; TREATMENT INDICATION; ETHICS; GERMANY; MEDICAL RESEARCH; NEUROSCIENCE;

BIOETHICAL ISSUES; BIOMEDICAL RESEARCH; DEEP BRAIN STIMULATION; GERMANY; HUMANS; MENTAL DISORDERS; NEUROSCIENCES; PERSONALITY;

EID: 59049095054     PISSN: 15420752     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.200800187     Document Type: Review

References (66)

1. McGee, E. M., Maguire, G. Q., Implantable brain chips: Ethical and policy issues. Med. Ethics 2001, 1-2, 8.
2. Greenfield, S. A., Biotechnology, the brain and the future. Trends Biotechnol. 2005, 23, 34-41.
3. Hoag, H., Remote control. Nature 2003, 423, 796-798.
4. Clausen, J., Ethical aspects of brain-computer interfacing in neuronal motor prostheses. Int. Rev. Inform. Ethics 2006, 5, 25-32.
5. Deuschl, G., Schade-Brittinger, C., Krack, P., Volkmann, J. et al., A randomized trial of deep-brain stimulation for Parkinson's disease. N. Engl. J. Med. 2006, 355, 896-908.
6. Perlmutter, J. S., Mink, J. W., Deep brain stimulation. Annu. Rev. Neurosci. 2006.
7. Kupsch, A., Benecke, R., Muller, J., Trottenberg, T. et al., Pallidal deep-brain stimulation in primary generalized or segmental dystonia. N. Engl. J. Med. 2006, 355, 1978-1990.
8. Wishart, H.A., Roberts, D. W., Roth, R. M., McDonald, B. C. et al., Chronic deep brain stimulation for the treatment of tremor in multiple sclerosis: Review and case reports. J. Neurol. Neurosurg. Psychiatry 2003, 74, 1392-1397.
9. Franzini, A., Ferroli, P., Leone, M., Broggi, G., Stimulation of the posterior hypothalamus for treatment of chronic intractable cluster headaches: First reported series. Neurosurgery 2003, 52, 1095-1099; discussion 1099-1101.
10. Yamamoto, T., Kobayashi, K., Kasai, M., Oshima, H. et al., DBS therapy for the vegetative state and minimally conscious state. Acta Neurochir. Suppl. 2005, 93, 101-104.
11. Schiff, N. D., Giacino, J. T., Kalmar, K., Victor, J. D. et al., Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature 2007, 448, 600-603.
12. Nuttin, B. J., Gabriels, L. A., Cosyns, P. R., Meyerson, B. A. et al., Long-term electrical capsular stimulation in patients with obsessive-compulsive disorder. Neurosurgery 2003, 52, 1263-1272; discussion 1272-1264.
13. Greenberg, B. D., Malone, D. A., Friehs, G. M., Rezai, A. R. et al., Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorder. Neuropsy-chopharmacology 2006, 31, 2384-2393.
14. Abelson, J. L., Curtis, G. C., Sagher, O., Albucher, R. C. et al., Deep brain stimulation for refractory obsessive-compulsive disorder. Biol. Psychiatry 2005, 57, 510-516.
15. Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E. et al., Deep brain stimulation for treatment-resistant depression. Neuron 2005, 45, 651-660.
16. Schlaepfer, T. E., Cohen, M.X., Frick, C., Kosel, M. et al., Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology 2008, 33, 368-377.
17. Malone, D. A. Jr., Dougherty, D. D., Rezai, A. R., Carpenter, L. L. et al., Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression. Biol. Psychiatry 2008.█update█
18. Lozano, A. M., Mayberg, H. S., Giacobbe, P., Hamani, C. et al., Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression. Biol. Psychiatry 2008, 64, 461-467.
19. Flaherty, A. W., Williams, Z. M., Amirnovin, R., Kasper, E. et al., Deep brain stimulation of the anterior internal capsule for the treatment of Tourette syndrome: Technical case report. Neurosurgery 2005, 57, E403; discussion E403.
20. Houeto, J. L., Karachi, C., Mallet, L., Pillon, B. et al., Tourette's syndrome and deep brain stimulation. J. Neurol. Neurosurg. Psychiatry 2005, 76, 992-995.
21. Sani, S., Jobe, K., Smith, A., Kordower, J. H., Bakay, R. A., Deep brain stimulation for treatment of obesity in rats. J. Neurosurg. 2007, 107, 809-813.
22. Hamani, C., McAndrews, M. P., Cohn, M., Oh, M. et al., Memory enhancement induced by hypothalamic/fornix deep brain stimulation. Ann. Neurol. 2008, 63, 119-123.
23. Franzini, A., Marras, C., Ferroli, P., Bugiani, O., Broggi, G., Stimulation of the posterior hypothalamus for medically intractable impulsive and violent behavior. Stereotact. Funct. Neurosurg. 2005, 83, 63-66.
24. Okun, M. S., Bowers, D., Springer, U., Shapira, N. A. et al., What's in a "smile-" Intra-operative observations of contralateral smiles induced by deep brain stimulation. Neurocase 2004, 10, 271-279.
25. Okun, M. S., Mann, G., Foote, K. D., Shapira, N. A. et al., Deep brain stimulation in the internal capsule and nucleus accumbens region: Responses observed during active and sham programming. J. Neurol. Neurosurg. Psychiatry 2007, 78, 310-314.
26. Hurley, D., Deep brain stimulation is used to suppress appetite in obese man Ñ And his memory improves. Neurol. Today 2008, 8, 11-12
27. Ford, P. J., Neurosurgical implants: Clinical protocol considerations. Camb. Q. Healthc Ethics 2007, 16, 308-311.
28. Fins, J. J., A leg to stand on: Sir William Osler and Wilder Penfield's "neuroethics". Am. J. Bioeth. 2008, 8, 37-46.
29. Kubu, C. S., Ford, P. J., Ethics in the clinical application of neural implants. Camb. Q. Healthc Ethics 2007, 16, 317-321.
30. Heller, A. C., Amar, A. P., Liu, C. Y., Apuzzo, M. L., Surgery of the mind and mood: A mosaic of issues in time and evolution. Neurosurgery 2006, 59, 720-733; discussion 733-729.
31. Fins, J. J., From psychosurgery to neuromodulation and palliation: History's lessons for the ethical conduct and regulation of neuropsychiatric research. Neurosurg. Clin. N. Am. 2003, 14, 303-319, ix-x.
32. Groß, D., Von der Topektomie zur modernen Stereotaxie: Die Geschichte psychochirurgischer Interventionen, in: Groß, D., Müller, S. (Eds.), Sind die Gedanken frei- Die Neurowissenschaften in Geschichte und Gegenwart, Medizinisch Wissenschaftliche Verlagsgesellschaft, Berlin 2007.
33. Valenstein, E., Great and Desperate Cures. The Rise and Decline of Psychosurgery and Other Radical Treatments for Mental Illness, Basic Books, New York 1986.
34. Board of Control, His Majesty's Stationery Office, Prefrontal Leucotomy in 1000 cases, London 1947.
35. Haddenbrock, S., Radikaloperation durch Defrontalisation-Theoretisches und Kritisches zur präfrontalen Leukotomie (Moniz). Med. Klin. 1949, 44, 69-74.
36. Fuchs, T., Ethical issues in neuroscience. Curr. Opin. Psychiatry 2006, 19, 600-607.
37. Abbott, A., Neuroscience: Deep in thought. Nature 2005, 436, 18-19.
38. Hildt, E., Electrodes in the brain: Some anthropological and ethical aspects of deep brain stimulation. Int. Rev. Inform. Ethics 2006, 5, 33-39.
39. Ford, P. J., Kubu, C. S., Stimulating debate: Ethics in a multi-disciplinary functional neurosurgery committee. J. Med. Ethics 2006, 32, 106-109.
40. Newen, A., Vogeley, K., Self-representation: Searching for a neural signature of self-consciousness. Conscious Cogn. 2003, 12, 529-543.
41. Synofzik, M., Vosgerau, G., Newen, A., I move, therefore I am: A new theoretical framework to investigate agency and ownership. Conscious Cogn. 2008, 17, 411-424.
42. Ryckman, R., Theories of Personality, Cengage Learning/Wadsworth, Belmont 2008.
43. Synofzik, M., Vosgerau, G., Newen, A., Beyond the comparator model: A multifactorial two-step account of agency. Conscious Cogn. 2008, 17, 219-239.
44. Haidt, J., The emotional dog and its rational tail: A social intuitionist approach to moral judgment. Psychol. Rev. 2001, 108, 814-834.
45. Greene, J. D., Haidt, J., How (and where) does moral judgment work- Trends Cogn. Sci. 2002, 6, 517-523.
46. Yelnik, J., Functional anatomy of the basal ganglia. Mov. Disord. 2002, 17 Suppl. 3, S15-21.
47. Smeding, H. M., Speelman, J. D., Koning-Haanstra, M., Schuurman, P. R. et al., Neuropsychological effects of bilateral STN stimulation in Parkinson disease: A controlled study. Neurology 2006, 66, 1830-1836.
48. Beauchamp, T., Childress, J., Principles of Biomedical Ethics, Oxford University Press, New York 2008.
49. Schupbach, M., Gargiulo, M., Welter, M. L., Mallet, L. et al., Neurosurgery in Parkinson disease: A distressed mind in a repaired body- Neurology 2006, 66, 1811-1816.
50. Agid, Y., Schupbach, M., Gargiulo, M., Mallet, L. et al., Neurosurgery in Parkinson's disease: The doctor is happy, the patient less so- J. Neural. Transm. Suppl. 2006, 409-414.
51. Drapier, S., Raoul, S., Drapier, D., Leray, E. et al., Only physical aspects of quality of life are significantly improved by bilateral subthalamic stimulation in Parkinson's disease. J. Neurol. 2005, 252, 583-588.
52. Derost, P. P., Ouchchane, L., Morand, D., Ulla, M. et al., Is DBS-STN appropriate to treat severe Parkinson disease in an elderly population- Neurology 2007, 68, 1345-1355.
53. Kenney, C., Simpson, R., Hunter, C., Ondo, W. et al., Short-term and long-term safety of deep brain stimulation in the treatment of movement disorders. J. Neurosurg. 2007, 106, 621-625.
54. Appleby, B. S., Duggan, P. S., Regenberg, A., Rabins, P. V., Psychiatric and neuropsychiatric adverse events associated with deep brain stimulation: A meta-analysis of ten years' experience. Mov. Disord. 2007, 22, 1722-1728.
55. Frank, M. J., Samanta, J., Moustafa, A.A., Sherman, S. J., Hold your horses: Impulsivity, deep brain stimulation, and medication in parkinsonism. Science 2007, 318, 1309-1312.
56. McNeely, H. E., Mayberg, H. S., Lozano, A. M., Kennedy, S. H., Neuropsychological impact of Cg25 deep brain stimulation for treatment-resistant depression: Preliminary results over 12 months. J. Nerv. Ment. Dis. 2008, 196, 405-410.
57. Shapira, N. A., Okun, M. S., Wint, D., Foote, K. D. et al., Panic and fear induced by deep brain stimulation. J. Neurol. Neurosurg. Psychiatry 2006, 77, 410-412.
58. Keller, M. B., Hirschfeld, R. M., Demyttenaere, K., Baldwin, D. S., Optimizing outcomes in depression: Focus on antidepressant compliance. Int. Clin. Psychopharmacol. 2002, 17, 265-271.
59. Mesnage, V., Houeto, J. L., Welter, M. L., Agid, Y. et al., Parkinson's disease: Neurosurgery at an earlier stage- J. Neurol. Neurosurg. Psychiatry 2002, 73, 778-779.
60. Welter, M. L., Houeto, J. L., Tezenas du Montcel, S., Mesnage, V. et al., Clinical predictive factors of subthalamic stimulation in Parkinson's disease. Brain 2002, 125, 575-583.
61. Schupbach, W. M., Maltete, D., Houeto, J. L., du Montcel, S. T. et al., Neurosurgery at an earlier stage of Parkinson disease: A randomized, controlled trial. Neurology 2007, 68, 267-271.
62. Russo, F., How to change a personality. Time Magazine, Thursday, Jan. 18, 2007, accessible at: http://www.time.com/time/magazine/article/ 0,9171,1580389,00.html; accessed at August 20, 2008.
63. Synofzik, M., Ethically justified, clinically applicable criteria for physician decision-making in psychopharmacological enhancement. Neuroethics 2009, in press.
64. Elliott, C., Better than Well: American Medicine meets the American Dream, Norton, New York 2003.
65. Juengst, E.T., What does enhancement mean-, in: Parens, E. (Ed.), Enhancing Human Traits. Ethical And Social Implications, Georgetown University Press, Washington 1998, pp. 29-47.
66. Montaurier, C., Morio, B., Bannier, S., Derost, P. et al., Mechanisms of body weight gain in patients with Parkinson's disease after subthalamic stimulation. Brain 2007, 130, 1808-1818.