Effects of maternal toluene exposure on testosterone levels in fetal rats

Toxicology Letters

Volumn 185, Issue 2, 2009, Pages 79-84

  Tsukahara, Shinji ^a   Nakajima, Daisuke ^a   Kuroda, Yoshiko ^a   Hojo, Rieko ^a   Kageyama, Shiho ^a   Fujimaki, Hidekazu ^a  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

Author keywords

3 Hydroxysteroid dehydrogenase; Steroidogenic enzyme; Testosterone; Toluene

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); CYTOCHROME P450; INSULIN DERIVATIVE; INSULIN LIKE 3; MESSENGER RNA; STEROID 17,20 LYASE; STEROID 17ALPHA MONOOXYGENASE; TESTOSTERONE; TESTOSTERONE 17BETA DEHYDROGENASE; TOLUENE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENZYME IMMUNOASSAY; FEMALE; FETUS; GESTATION PERIOD; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEYDIG CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; STEROID BLOOD LEVEL; TESTIS; TESTOSTERONE BLOOD LEVEL; TESTOSTERONE RELEASE; TESTOSTERONE SYNTHESIS;

AIR POLLUTANTS; ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FETAL BLOOD; INHALATION EXPOSURE; MALE; MATERNAL EXPOSURE; MATERNAL-FETAL EXCHANGE; POLYMERASE CHAIN REACTION; PREGNANCY; RATS; RATS, LONG-EVANS; TESTIS; TESTOSTERONE; TOLUENE;

RATTUS;

EID: 59049083085     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.12.001     Document Type: Article

References (22)

1. Adham I.M., Burkhardt E., Benahmed M., and Engel W. Cloning of a cDNA for a novel insulin-like peptide of the testicular Leydig cells. J. Biol. Chem. 268 (1993) 26668-26672
2. Balvers M., Spiess A.N., Domagalski R., Hunt N., Kilic E., Mukhopadhyay A.K., Hanks E., Charlton H.M., and Ivell R. Relaxin-like factor expression as a marker of differentiation in the mouse testis and ovary. Endocrinology 139 (1998) 2960-2970
3. Donald J.M., Hooper K., and Hopenhayn-Rich C. Reproductive and developmental toxicity of toluene: a review. Environ. Health Perspect. 94 (1991) 237-244
4. Hansson T., Pettersson B.M., Eneroth P., and Gustafsson J.A. Neonatal exposure to toluene: effects on the development of liver microsomal cytochrome P-450 and serum hormone levels in the rat. Toxicology 37 (1985) 39-50
5. Huhtaniemi I., and Pelliniemi L.J. Fetal Leydig cells: cellular origin, morphology, life span, and special functional features. Proc. Soc. Exp. Biol. Med. 201 (1992) 125-140
6. Hutson J.M., Hasthorpe S., and Heyns C.F. Anatomical and functional aspects of testicular descent and cryptorchidism. Endocr. Rev. 18 (1997) 259-280
7. MacLusky N.J., and Naftolin F. Sexual differentiation of the central nervous system. Science 211 (1981) 1294-1302
8. McKinnell C., Sharpe R.M., Mahood K., Hallmark N., Scott H., Ivell R., Staub C., Jegou B., Haag F., Koch-Nolte F., and Hartung S. Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate. Endocrinology 146 (2005) 4536-4544
9. Morris J.A., Jordan C.L., and Breedlove S.M. Sexual differentiation of the vertebrate nervous system. Nat. Neurosci. 7 (2004) 1034-1039
10. Nef S., and Parada L.F. Cryptorchidism in mice mutant for Insl3. Nat. Genet. 22 (1999) 295-299
11. Omura T., and Morohashi K. Gene regulation of steroidogenesis. J. Steroid Biochem. Mol. Biol. 53 (1995) 19-25
12. Payne A.H., and Hales D.B. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocr. Rev. 25 (2004) 947-970
13. Pusch W., Balvers M., and Ivell R. Molecular cloning and expression of the relaxin-like factor from the mouse testis. Endocrinology 137 (1996) 3009-3013
14. Slob A.K., Ooms M.P., and Vreeburg J.T. Prenatal and early postnatal sex differences in plasma and gonadal testosterone and plasma luteinizing hormone in female and male rats. J. Endocrinol. 87 (1980) 81-87
15. Svensson B.G., Nise G., Erfurth E.M., Nilsson A., and Skerfving S. Hormone status in occupational toluene exposure. Am. J. Ind. Med. 22 (1992) 99-107
16. Svensson B.G., Nise G., Erfurth E.M., and Olsson H. Neuroendocrine effects in printing workers exposed to toluene. Br. J. Ind. Med. 49 (1992) 402-408
17. Warren D.W., Haltmeyer G.C., and Eik-Nes K.B. Testosterone in the fetal rat testis. Biol. Reprod. 8 (1973) 560-565
18. Weisz J., and Ward I.L. Plasma testosterone and progesterone titers of pregnant rats, their male and female fetuses, and neonatal offspring. Endocrinology 106 (1980) 306-316
19. Win-Shwe T.T., Tsukahara S., Ahmed S., Fukushima A., Yamamoto S., Kakeyama M., Nakajima D., Goto S., Kobayashi T., and Fujimaki H. Athymic nude mice are insensitive to low-level toluene-induced up-regulation of memory-related gene expressions in the hippocampus. Neurotoxicology 28 (2007) 957-964
20. Yilmaz B., Canpolat S., Sandal S., Akpolat N., Kutlu S., Ilhan N., and Kelestimur H. Paint thinner exposure inhibits testosterone synthesis and secretion in a reversible manner in the rat. Reprod. Toxicol. 22 (2006) 791-796
21. Yilmaz B., Kutlu S., Canpolat S., Sandal S., Ayar A., Mogulkoc R., and Kelestimur H. Effects of paint thinner exposure on serum LH, FSH and testosterone levels and hypothalamic catecholamine contents in the male rat. Biol. Pharm. Bull. 24 (2001) 163-166
22. Zimmermann S., Steding G., Emmen J.M., Brinkmann A.O., Nayernia K., Holstein A.F., Engel W., and Adham I.M. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol. Endocrinol. 13 (1999) 681-691